| Project/Area Number |
16591124
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Psychiatric science
|
|---|
| Research Institution | University of Yamanashi |
|---|
Principal Investigator |
MOTOHASHI Nobutaka University of Yamanashi, Department of Research Interdisciplinary Graduate School of Medicine and Engineering, Professor, 大学院・医学工学総合研究部, 教授 (30166342)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ARAGAKI Hiroshi Tokyo Medical and Dental University, Graduate School of Medical and Dental Research, Research Associate, 大学院・医歯学総合研究科, 助手 (40334437)
TERADA Tomo Tokyo Medical and Dental University, Graduate School of Medical and Dental Research, Research Associate, 大学院・医歯学総合研究科, 助手 (50361712)
TAKEUCHI Takashi Tokyo Medical and Dental University, Medical Hospital, Research Associate, 医学部附属病院, 助手 (70345289)
SUHARA Tetsuya National Institute of Radiological Sciences, Department of Molecular Neuroimaging, Leader, 重粒子医科学研究センター, 室長(特別上席研究員) (90216490)
|
|---|
| Project Period (FY) |
2004 – 2005
|
| Project Status |
Completed (Fiscal Year 2005)
|
| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2005: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2004: ¥1,900,000 (Direct Cost: ¥1,900,000)
|
|---|
| Keywords | repetitive transcranial magnetic stimulation / depression / dopamine / PET / ^<11>C-raclopride / 反復性磁気刺激療法 |
|---|
| Research Abstract |
Several studies have demonstrated that repetitive transcranial magnetic stimulation (rTMS) elicits moderate antidepressant effects. Several previous studies suggested that the dopaminergic system might be related to this therapeutic action of rTMS. We attempted to determine the effects of chronic rTMS on central dopaminergic function in depression using positron emission tomography (PET) with [^<11>C]raclopride. Nine patients with depression were treated with 10 daily sessions of rTMS (10Hz, 5sec train, 20 trains at 100% motor threshold per session) over the left dorsolateral prefrontal cortex (DLPFC). Each patient underwent two [^<11>C]raclopride PET scans and neuropsychological tests - before rTMS and 1 day after rTMS. In five patients, the Hamilton Rating Scale for Depression (HRSD) significantly decreased. Patients showed significant improvement in verbal memory following rTMS. There were no changes in [^<11>C]raclopride binding in the caudate nucleus and putamen after rTMS treatment. Our sample size was limited, and our study was an open trial lacking sham-treated This study suggests that rTMS may be effective for the treatment of depression and also may improve verbal memory function. We observed no changes in [^<11>C]raclopride binding, suggesting that there was no measurable increase in the release of dopamine at the second PET scan. Several animal studies and healthy human studies have indicated that dopamine can be released soon after acute rTMS. Our results suggest that release of striatal dopamine induced by rTMS may be only transient, or that dopamine release may be attenuated following chronic rTMS.
|
