| Project/Area Number |
16591152
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Yokohama City University |
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Principal Investigator |
KAWANISHI Chiaki Yokohama City University, Department of Psychiatry, M.D., Ph.D.Associate Professor (50315769)
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| Co-Investigator(Kenkyū-buntansha) |
HIRAYASU Yoshio Yokohama City University, Deparetment of Psychiatry, School of Mdicine, M.D., Ph.D.Professor and Director (70244324)
YAMADA Tomoki Yokohama City University, Deparetment of Psychiatry, School of Mdicine, M.D.Assistant Professor (00315813)
KATO Daiji Yokohama City University, Deparetment of Psychiatry, School of Mdicine, M.D.Assistant Professor (70363819)
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| Project Period (FY) |
2004 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,540,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2006: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2005: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2004: ¥900,000 (Direct Cost: ¥900,000)
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| Keywords | Suicide / Suicide attempt / Risk factors / Genetic polymorphism / Behavioral Medicine / セロトニン・トランスポーター / セロトニン受容体 / 自殺企画 / 精神疾患 / うつ病 / 統合失調症 |
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| Research Abstract |
The incidence of suicide has increased markedly in Japan since 1998. Since psychological autopsy is not generally accepted in Japan, surveys of suicide attempts, an established risk factor of suicide, are highly regarded. In the present research,564 consecutive suicide attempters who were admitted to an urban emergency department were interviewed with the focus on current and previous suicide attempts, psychosocial background, and psychiatric diagnosis according to DSM-IV. Moreover, impulsivity and aggression were evaluated using standardized scales. Among those attempters 120 attempters and 123 unrelated individuals (healthy controls) were subjected to genetic association studies. Polymerase chain reaction and restriction fragment length polymorphism analyses were performed to determine polymorphisms of the serotonin transporter, 5HTIB, and 14-3-3-ε genes.
The most frequent suicide method was over-dosing, followed by cutting, diving, and hanging. Health problem and human relations were common suicide motives. At least 68 percent of patients met criteria for an axis I disorder. Most frequent diagnosis was mood disorder. Both trait aggression and impulsivity were higher in suicide attempters compared with controls. Regarding genetic background in suicide behavior, G861C of the 5HT1B gene tends to relate to less impulsivity in attempters.
This is the first large-scale study of suicide attempters since the dramatic increase in suicide began in Japan. Information on property of suicide attempters from various viewpoints is necessary when effective measure is developed.
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