| Project/Area Number |
16591164
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | THE JIKEI UNIVERSITY SCHOOL OF MEDICINE |
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Principal Investigator |
KASAHARA Hiroo The Jikei University School of Medicine, Professor, 医学部, 教授 (60056950)
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| Co-Investigator(Kenkyū-buntansha) |
NAKANISHI Tatsurou The Jikei University School of Medicine, Research Assistant, 医学部, 助手 (10287261)
HASHIDUME Toshihiko The Jikei University School of Medicine, Research Assistant, 医学部, 助手 (10317985)
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 2005: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2004: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | MRI / BVRT / Enhanced cued recall / rating scale / brain atrophy / aging |
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| Research Abstract |
The study commenced with the participation of 100 subjects per year in 1999. Since fiscal 2002,80 subjects per year have been studied. Three surveys were completed for a total of 651 subjects : 306 in the first survey,243 in the second survey, and 102 in the third survey. At the start of the first survey, the subjects were divided into two age groups : those not older than 69 years (younger group) and those not younger than 70 years (older group). Changes in cognitive test results from each group with aging were analyzed. Benton's visual encoding test revealed a stable course with little changes in both right answer rate and error rate for the younger group, but the error rate increased over time for the older group. Results of free reproduction of enhanced cued recalls (ECRs) were stable with a slight increase in the score for the younger group but decreased over years for the older group. The total number of ECRs reproduced showed only a slight reduction for both groups. Magnetic resonance imaging (MRI) revealed a particularly high prevalence of T_2 high signal intensity (T_2HSI), the second highest prevalence observed in the temporal lobe. "Lateral ventricle enlargement," "third ventricle enlargement" and "temporal lobe atrophy" showed a remarkable tendency for increases with aging, demonstrating that ventricular enlargement and temporal lobe atrophy increase at constant rate over years even among healthy elderly persons. "Cerebellum atrophy" and "pons atrophy" did not progress with aging. For the corpus callosum, atrophy progressed over time in the older group. During this study to date, six of the first survey participants died, four experienced dementia (including one case of Pick's disease), and 18 became difficult to continue to participate in the study because of physical issues such as development of cerebral infarction.
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