| Project/Area Number |
16591167
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
MATSUURA Masato Tokyo Medical and Dental University, Biofunctional Informatics, Professor, 大学院・保健衛生学研究科, 教授 (60134673)
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| Co-Investigator(Kenkyū-buntansha) |
KOJIMA Takuya Nihon University School of Medicine, Neuropsychiatry, Professor, 医学部, 教授 (40014203)
OHKUBO Tatsunobu Nihon University School of Medicine, Neuropsychiatry, Senior Resident, 医学部, 助手 (90328716)
OHKUBO Hiromi Nihon University School of Medicine, Neuropsychiatry, Senior Resident, 医学部, 助手 (00203737)
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2005: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2004: ¥2,500,000 (Direct Cost: ¥2,500,000)
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| Keywords | fMRI / schizophrenia / epileptic psychosis / organic psychosis / visually-guided saccades / antisaccades / memory-guided saccades / smooth pursuit eye movements / smooth pursuit eye movements / neural circuitry |
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| Research Abstract |
We have conducted a functional magnetic resonance imaging study on a supposed common neural circuit dysfunction among schizophrenia, epileptic psychosis, and organic psychosis using various eye movement tasks. The data from 21 healthy controls, 18 schizophrenics, five epileptics with psychosis, and four organics with psychosis were obtained. The visually-guided saccade task showed activations on cortical eye-movement neural circuit consisted of frontal, supplementary, and parietal eye field. The cortical circuit over-activations including prefrontal area were found in the patient groups compared with the control. The anti-saccade task showed physiological enhancement in fronto-parietal cortical circuit activation in the control as well as in the schizophrenia group with good performance. While these physiological enhancement was not found in the patient groups of schizophrenia with poor performance, epileptic psychosis, and organic psychosis. The anti-saccade task also activated a subc
… More
ortical thalamo-striatal circuit in the control, while no subcortical activation was found in the patients groups. The memory-guided saccade task showed physiological enhancements both in prefronto-fronto-parietal and thalamo-striatal circuits in parallel with increasing task difficulty. While these task-difficulty dependent prefrontal and thalamo-striatal enhancements were not found in the schizophrenia group. The standard pursuit task showed left-hemisphere activations in fronto-parietal eye movement circuit as well as lateral-parieto-occipital junction. The flash-counting pursuit task, an attention enhance procedure, showed increased activation at right-hemisphere in the groups of control, epileptic psychosis, and organic psychosis. While the attention-related increased activation was not found in the schizophrenia group. Therefore, we can conclude that common dysfunction in eye-movement related cortical circuit as well as subcortical circuit exist among psychoses. In addition, a dysfunctional connection between left-and-right hemisphere may exit in schizophrenia. Less
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