| Project/Area Number |
16591173
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Kansai Medical University |
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Principal Investigator |
KINOSHITA Toshihiko (2007) Kansai Medical University, Neuropsychiatry, professor (20186290)
延原 健二 (2004-2006) 関西医科大学, 医学部, 助教授 (90247932)
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| Co-Investigator(Kenkyū-buntansha) |
OKUGAWA Gaku Kansai Medical University, Neuropsychiatry, associate professor (80343672)
木下 利彦 関西医科大学, 医学部, 教授 (20186290)
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| Project Period (FY) |
2004 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,320,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥120,000)
Fiscal Year 2007: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2006: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2005: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2004: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | brain・nerve / cranial nerve disease / 強迫性障害 / MRI / 拡散テンソル / 線維連絡 / 白質 |
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| Research Abstract |
Purpose:
To prospectively examine white matter microstructural abnormalities in the corpus callosum (CC) of OCD patients, as compared with controls, and to investigate the relationship between DTI measures of the CC region and clinical symptoms in OCD.
Materials and Methods :
Institutional review board approval was obtained, and each participant (or parents) provided written informed consent. 16 patients with OCD (7 men, 9 women; mean±SD age, 28.7±9.8) and matched control subjects (7 men, 9 women; mean±SD age, 29.9±9.0). Mean diffusivity (MD) and fractional anisotropy (FA) were measured in the five subdivisions of the CC. Paired t test was used to compare MD or FA of CC regions from patients with OCD and controls.
Results :
There were no significant differences (rostrum, p=0.15; genu, p=0.88; rostral body, p=0.12; isthmus, p=0.77; splenium, p=0.88) of MD between patients with OCD and healthy volunteers. A significant reduction in FA was found in the rostrum of the CC of patients with OCD compared with that of controls (P < 0.001). Higher FA only in the rostrum correlated significantly with lower Y-BOCS scores (r=-0.72, p=0.002).
Conclusions :
Our results support the widely held view that the orbital prefrontal region is involved in the pathophysiology of OCD and also imply involvement of the orbitofrontal circuit in symptom severity in OCD patients.
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