The corpus callosum in obsessive-compulsive disorder : a diffusion tensor imaging study

• Project/Area Number: 16591173
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Kansai Medical University
• Principal Investigator: KINOSHITA Toshihiko (2007) Kansai Medical University, Neuropsychiatry, professor (20186290); 延原 健二 (2004-2006) 関西医科大学, 医学部, 助教授 (90247932)
• Co-Investigator(Kenkyū-buntansha): OKUGAWA Gaku Kansai Medical University, Neuropsychiatry, associate professor (80343672) ; 木下 利彦 関西医科大学, 医学部, 教授 (20186290)
• Project Period (FY): 2004 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥3,320,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥120,000); Fiscal Year 2007: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2006: ¥900,000 (Direct Cost: ¥900,000); Fiscal Year 2005: ¥700,000 (Direct Cost: ¥700,000); Fiscal Year 2004: ¥1,200,000 (Direct Cost: ¥1,200,000)
• Keywords: brain・nerve / cranial nerve disease / 強迫性障害 / MRI / 拡散テンソル / 線維連絡 / 白質

Research Abstract

Purpose:
To prospectively examine white matter microstructural abnormalities in the corpus callosum (CC) of OCD patients, as compared with controls, and to investigate the relationship between DTI measures of the CC region and clinical symptoms in OCD.
Materials and Methods :
Institutional review board approval was obtained, and each participant (or parents) provided written informed consent. 16 patients with OCD (7 men, 9 women; mean±SD age, 28.7±9.8) and matched control subjects (7 men, 9 women; mean±SD age, 29.9±9.0). Mean diffusivity (MD) and fractional anisotropy (FA) were measured in the five subdivisions of the CC. Paired t test was used to compare MD or FA of CC regions from patients with OCD and controls.
Results :
There were no significant differences (rostrum, p=0.15; genu, p=0.88; rostral body, p=0.12; isthmus, p=0.77; splenium, p=0.88) of MD between patients with OCD and healthy volunteers. A significant reduction in FA was found in the rostrum of the CC of patients with OCD compared with that of controls (P < 0.001). Higher FA only in the rostrum correlated significantly with lower Y-BOCS scores (r=-0.72, p=0.002).
Conclusions :
Our results support the widely held view that the orbital prefrontal region is involved in the pathophysiology of OCD and also imply involvement of the orbitofrontal circuit in symptom severity in OCD patients.

Research Products

• [Journal Article] Corpus Callosum in Patients with Obsessive-Compulsive Disorder:Diffusion-Tensor Imaging Study (2008)
  • Author(s): Saito Y
  • Journal Title: Radiology 246 Pages: 536-542
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Corpus Callosum in Patients with Obsessive-Compulsive Disorder:Diffusion-Tensor Imaging Study (2008)
  • Author(s): Saito Y, Nobuhara K, Okugawa G, Takase K, Sugimoto T, Horiuchi M, Ueno C, Maehara M, Omura N, Kurokawa H, Ikeda K, Tanigawa N, Sawada S, Kinoshita T.
  • Journal Title: Radiology 246 Pages: 536-542
  • Peer Reviewed
• [Journal Article] 強迫の診立てと治療I 強迫性障害における脳画像研究 (2007)
  • Author(s): 齋藤 幸子
  • Journal Title: 精神科治療学 22 Pages: 517-521
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 強迫の診立てと治療I 強迫性障害における脳画像研究 (2007)
  • Author(s): 齊藤 幸子、延原 健二、奥川 学、高瀬 勝教、上野 千穂、木下 利彦
  • Journal Title: 精神科治療学 22 Pages: 517-521
  • Peer Reviewed
• [Presentation] WHITE MATTER ABNORMALITIES IN OBSESSIVE-COMPULSIVE DISORDER:A DIFFUSION TENSOR IMAGING STUDY (2007)
  • Author(s): 齋藤 幸子
  • Organizer: 第29回日本生物学的精神医学会
  • Place of Presentation: 北海道
  • Year and Date: 2007-07-13
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 1 Department of Neuropsychiatry ; 2 Department of Radiology, Kansai Medical University, Osaka, JapanWHITE MATTER ABNORMALITIES IN OBSESSIVE-COMPULSIVE DISORDER A DIFFUSION TENSOR IMAGING STUDY (2007)
  • Author(s): Y. Saito^1, K. Nobuhara^1, G. Okugawa^1, K. Takase^1, T. Sugimoto^1, K. Ikeda^2, S. Sawada^2, T. Kinoshita^1
  • Organizer: 29th Japanese Society of Biological Psychiatry
  • Place of Presentation: Hokkaido, Japan
  • Year and Date: 2007-07-13
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] WHITE MATTER ABNORMALITIES IN OBSESSIVE-COMPULSIVE DISORDER:ADIFFUSION TENSOR IMAGING STUDY (2007)
  • Author(s): 齊藤 幸子、延原 健二、奥川 学、高瀬 勝教、杉本 達哉、池田 耕士、澤田 敏、木下 利彦
  • Organizer: 第29回日本生物学的精神医学会
  • Place of Presentation: 北海道
  • Year and Date: 2007-07-13
• [Presentation] 強迫性障害における白質異常 (2006)
  • Author(s): 齋藤 幸子
  • Organizer: 第28回日本生物学的精神医学会
  • Place of Presentation: 名古屋
  • Year and Date: 2006-09-16
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 1 Department of Neuropsychiatry ; 2 Department of Radiology, Kansai Medical University, Osaka, JapanWHITE MATTER ABNORMALITIES IN OBSESSIVE-COMPULSIVE DISORDER (2006)
  • Author(s): Y. Saito^1, K. Nobuhara^1, G. Okugawa^1, K. Takase^1, T. Sugimoto^1, K. Ikeda^2, S. Sawada^2, T. Kinoshita^1
  • Organizer: 28th Japanese Society of Biological Psychiatry
  • Place of Presentation: Nagoya, Japan
  • Year and Date: 2006-09-16
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] THE CORPUS CALLOSUM IN OBSESSIVE-COMPULSIVE DISORDER:A DIFFUSION TENSOR IMAGING STUDY (2006)
  • Author(s): Y.Saito
  • Organizer: 14th AEP Congress-Association of European Psychiatrists
  • Place of Presentation: フランス
  • Year and Date: 2006-03-07
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 1 Department of Neuropsychiatry ; 2 Department of Radiology, Kansai Medical University, Osaka, JapanTHE CORPUS CALLOSUM IN OBSESSIVE-COMPULSIVE DISORDER A DIFFUSION TENSOR IMAGING STUDY (2006)
  • Author(s): Y. Saito^1, K. Nobuhara^1, G. Okugawa^1, K. Takase^1, T. Sugimoto^1, K. Ikeda^2, S. Sawada^2, T. Kinoshita^l
  • Organizer: 14th Association of European Psychiatrists Congress
  • Place of Presentation: France
  • Year and Date: 2006-03-07
  • Description: 「研究成果報告書概要(欧文)」より