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Investigation of mechanisms mediating pubertal treatment of marihuana-induced psychosis

Research Project

Project/Area Number 16591174
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionFukuoka University

Principal Investigator

EGASHIRA Nobuaki  Fukuoka University, Faculty of Pharmaceutical Sciences, Assistant Professor, 薬学部, 助手 (80352269)

Co-Investigator(Kenkyū-buntansha) FUJIWARA Michihiro  Fukuoka University, Faculty of Pharmaceutical Sciences, Professor, 薬学部, 教授 (10091331)
NISHIMURA Ryoji  Fukuoka University, School of Medicine, Professor, 医学部, 教授 (10122722)
IWASAKI Katsunori  Fukuoka University, Faculty of Pharmaceutical Sciences, Associate Professor, 薬学部, 助教授 (10183196)
MISHIMA Kenichi  Fukuoka University, Faculty of Pharmaceutical Sciences, Assistant Professor, 薬学部, 助手 (00320309)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2005: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2004: ¥2,200,000 (Direct Cost: ¥2,200,000)
KeywordsΔ^9-Tetrahydrocannabinol / CB_1 cannabinoid receptor / Prepulse inhibition / Psychosis / Pubertal / Sensorimotor gating / Δ9-tetrahydrocannabinol (THC) / prepulse inhibition (PPI) / 若年期、思春期
Research Abstract

There is evidence from studies in humans and animals that a vulnerable period for chronic cannabinoid administration exists during certain phases of development. In the present study, we investigated whether the chronic administration of Δ^9-tetrahydrocannabinol (THC), the major psychoactive component of cannabis, during development impairs the prepulse inhibition (PPI) of the startle reflex in adult mice. The male ddY mice at 8 weeks of age received 21 injections subcutaneous (s.c.) daily. We examined the effect of chronic THC on the PPI, open-field, rota-rod, catalepsy, plus maze and forced swimming tests. As a result, the PPI was significantly disrupted by chronic pubertal THC treatment at 21 days after chronic injection, and these deficits continued until 56 days after chronic injection. In contrast, chronic THC had no effect on the startle response, motor function such as locomotor activity and catalepsy, anxiety and depression. Thus, THC-induced PPI deficits were not due to change of startle response, motor impairment, anxiety and depression. We therefore conclude that development in mice is a vulnerable period with respect to the adverse effects of THC treatment. Since PPI deficits are among the endophenotypes of schizophrenia, we thus propose the chronic administration of THC during development as an animal model for some aspects of the etiology of schizophrenia.

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (20 results)

All 2006 2005 2004

All Journal Article (20 results)

  • [Journal Article] Low dose citalopram reverses memory impairment and electroconvulsive shock-induced immobilization2006

    • Author(s)
      Nobuaki Egashira
    • Journal Title

      Pharmacol Biochem Behav. 83巻1号

      Pages: 161-167

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 若齢期における大麻成分慢性投与による情報処理障害の発現-若齢マウスを用いたPrepulse inhibitionの検討-2006

    • Author(s)
      永井 宏
    • Journal Title

      福岡大学医学紀要 33巻1号

      Pages: 53-61

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Investigation of mechanisms mediating 8-OH-DPAT-induced impairment of spatial memory : Involvement of 5-HT_<1A> receptors in the dorsal hippocampus in rats2006

    • Author(s)
      Nobuaki Egashira
    • Journal Title

      Brain Res. 1069巻1号

      Pages: 54-62

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Low dose citalopram reverses memory impairment and electroconvulsive shock-induced immobilization2006

    • Author(s)
      Nobuaki Egashira
    • Journal Title

      Pharmacol Biochem Behav. 83(1)

      Pages: 161-167

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Chronic Δ^9-Tetrahydrocannabinol Treatment Impairs Prepulse Inhibition in Mice2006

    • Author(s)
      Hiroshi Nagai
    • Journal Title

      Medical Bulletin of Fukuoka University 33(1)

      Pages: 53-61

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Investigation of mechanisms mediating 8-OH-DPAT-induced impairment of spatial memory : Involvement of 5-HT_<1A> receptors in the dorsal hippocampus in rats2006

    • Author(s)
      Nobuaki Egashira
    • Journal Title

      Brain Res. 1069(1)

      Pages: 54-62

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 若齢期における大麻成分慢性投与による情報処理障害の発現 -若齢マウスを用いたPrepulse inhibitionの検討-2006

    • Author(s)
      永井宏
    • Journal Title

      福岡大学医学紀要 33巻1号

      Pages: 53-61

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Low dose citalopram reverses memory impairment and electroconvulsive shock-induced immobilization2006

    • Author(s)
      Nobuaki Egashira
    • Journal Title

      Pharmacol Biochem Behav 83巻1号

      Pages: 161-167

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Cannabidiol prevents cerebral infarction via a serotonergic 5-hydroxytryptaminelA receptor-dependent mechanism2005

    • Author(s)
      Kenichi Mishima
    • Journal Title

      Stroke 36巻5号

      Pages: 1071-1076

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Anandamide inhibits the DOI-induced head-twitch response in mice2004

    • Author(s)
      Nobuaki Egashira
    • Journal Title

      Psychopharmacology (Berl) 171巻4号

      Pages: 382-389

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 特集2 : 生物学的精神医学研究の現状と展望(4)薬学部との共同による精神行動薬学的研究-福岡大学における取り組みを中心に2004

    • Author(s)
      永井 宏
    • Journal Title

      脳と精神の医学 15巻4号

      Pages: 461-466

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The serotonin_<1A> receptor agonist 8-OH-DPAT reverses Δ^9-tetrahydro-cannabinol-induced impairment of spatial memory and reduction of acetylcholine release in the dorsal hippocampus in rats2004

    • Author(s)
      Keiichiro Inui
    • Journal Title

      Neurotoxicity Res. 6巻2号

      Pages: 153-158

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Anandamide inhibits the DOI-induced head-twitch response in mice2004

    • Author(s)
      Nobuaki Egashira
    • Journal Title

      Psychopharmacology(Berl) 171(4)

      Pages: 382-389

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Behavioral pharmacological study in collaboration with Department of Neuropharmacology : review with emphasis on studies in the Department of Psychiatry, School of Medicine, Fukuoka University2004

    • Author(s)
      Hiroshi Nagai
    • Journal Title

      Brain Science and Mental Disorders 15(4)

      Pages: 461-466

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The serotonin_<1A> receptor agonist 8-OH-DPAT reverses Δ^9-tetrahydro-cannabinol-induced impairment of spatial memory and reduction of acetylcholine release in the dorsal hippocampus in rats2004

    • Author(s)
      Keiichiro Inui
    • Journal Title

      Neurotoxicity Res. 6(2)

      Pages: 153-158

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] New perspectives in the studies on endocannabinoid and cannabis : abnormal behaviors associate with CB1 cannabinoid receptor and development of therapeutic application2004

    • Author(s)
      Michihiro Fujiwara
    • Journal Title

      J.Pharmacol.Sci. 96(4)

      Pages: 362-366

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Anandamide inhibits the DOI-induced head-twitch response in mice2004

    • Author(s)
      Nobuaki Egashira
    • Journal Title

      Psychopharmacology 171

      Pages: 382-389

    • Related Report
      2004 Annual Research Report
  • [Journal Article] The serotonin 1A receptor agonist 8-OH DPAT reverses Δ9-tetrahydrocannabinol-induced impairment of spatial memory and reduction of acetylcholine release in the dorsal hippocampus in rats2004

    • Author(s)
      Keiichiro Inui
    • Journal Title

      Neurotoxicity Research 6

      Pages: 153-158

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Cannabidiol prevents infarction via the non-CB1 cannabinoid receptor mechanism2004

    • Author(s)
      Kazuhide Hayakawa
    • Journal Title

      Neuroreport 15(15)

      Pages: 2381-2385

    • Related Report
      2004 Annual Research Report
  • [Journal Article] New perspectives in the studies on endocannabinoid and cannabis : abnormal behaviors associate with CB1 cannabinoid receptor and development of therapeutic application2004

    • Author(s)
      Michihiro Fujiwara
    • Journal Title

      Journal of Pharmacological Sciences 96

      Pages: 2132-2141

    • Related Report
      2004 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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