| Project/Area Number |
16591186
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Chiba University |
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Principal Investigator |
ITO Hisao Chiba Univ., Graduate School of Med, Prof., 大学院・医学研究院, 教授 (20095574)
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| Co-Investigator(Kenkyū-buntansha) |
KAWATA Tetsuya Chiba Univ., Graduate School of Med, Assistant Prof., 大学院・医学研究院, 講師 (60234077)
UNO Takashi Chiba Univ., Graduate School of Med, Associate Prof., 大学院・医学研究院, 助教授 (30302540)
ISOBE Koichi Chiba Univ., University Hospital, Assistant Prof., 医学部附属病院, 講師 (80334184)
YAMAMOTO Seiji Chiba Univ., University Hospital, Assistant Prof., 医学部附属病院, 講師 (40302567)
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2005: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2004: ¥2,300,000 (Direct Cost: ¥2,300,000)
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| Keywords | melatonin / radiation protection / normal tissue damage / ATM / 放射線感受性 / 線維芽細胞 |
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| Research Abstract |
The purpose of radiotherapy is to give maximum damage to malignant cells and to give minimum damage to normal tissue. The normal tissue can be protected from radiation damage with radioprotective drugs. However, these drugs have usually severe adverse effects and it is difficult to apply these clinically. Melatonin is secreted body mostly at night from the pineal, and adjusts biological rhythm such as sleep and activity. This is clinically applied to treat jet-lag in USA and Europe. There is little adverse effect and large dose can be given. In this study, protective effect of melatonin on irradiation-induced chromosome aberration was determined in vitro and in vivo. In 2004, effect of melatonin on cultured cells was determined. The radioprotecitve effect of melatonin was not significant, because melatonin is lipid-soluble and ethanol is necessary to make solution. Ethanol is toxic to cells and it is difficult to make high concentration solution. In 2005, H3H/He and AT heterozygous mice were irradiated and effect of melatonin on protecting radiation damage was determined. There was no significant different between both kinds of mice and radioprotective effect of melatonin was not certified. At present, it is difficult to apply melatonin as a radioprotective drug clinically.
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