Approaching angiogenesis of liver cancer using radiologic imaging

• Project/Area Number: 16591197
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Gifu University
• Principal Investigator: KANEMATSU Masayuki Gifu University, University Hospital, Associate Professor, 医学部附属病院, 助教授 (40252134)
• Co-Investigator(Kenkyū-buntansha): OSADA Shinji Gifu University, University Hospital, Assistant Professor, 医学部附属病院, 講師 (80332683) ; AMAOKA Nozomi Gifu University, Graduate School of Medicine, Research Associate, 大学院・医学系研究科, 助手 (80362143) ; MATSUO Masayuki Gifu University, University Hospital, Research Associate, 医学部附属病院, 助手 (40377669) ; KATO Hiroki Gifu University, University Hospital, Research Associate, 医学部附属病院, 助手 (70377670)
• Project Period (FY): 2004 – 2005
• Project Status: Completed (Fiscal Year 2005)
• Budget Amount: ¥1,500,000 (Direct Cost: ¥1,500,000); Fiscal Year 2005: ¥400,000 (Direct Cost: ¥400,000); Fiscal Year 2004: ¥1,100,000 (Direct Cost: ¥1,100,000)
• Keywords: angiogenesis / VEGF / hepatocellular carcinoma / liver cancer / CT / MRI / angiography / 血管新生 / 血管内皮細胞増殖因子

Research Abstract

We have reviewed the historical development of various diagnostic imaging modalities for the evaluation of HCC. We further described the research publications on the correlation of VEGF and imaging findings. The apparently discrepant observations of the extent of correlation of VEGF activity and HCC, we believe likely reflects that different studies contained patients with HCCs of different evolution. Based on our research studies, we have observed that VEGF appears to correlate with increased tissue fluid, which on MRI appears as low signal on T1-weighted images and high signal on T2-weighted images. It is our impression that VEGF increases as a precursor to increased vascularity, as vascularity increases, seen in small HCCs, VEGF is downregulated and as tumor increases to larger size, > 3 cm, VEGF may again increase in response to hypoxia.
The future clinical impact of VEGF measurements and correlation of VEGF values with imaging results have yet to be determined. Our hope is that VEGF measurements will provide insight into the angiogenic potential of tumors, and also predict or reflect response to therapeutic interventions.

Research Products

• [Journal Article] High-Spatial-Resolution Gadolinium-Enhanced Double Hepatic Arterial-Phase MR Imaging of the Liver with Reversed Centric and Centric K-Space Reordering Switching. (2006)
  • Author(s): Kanematsu M, Goshima S, Kondo H, Yokoyama R, Kajita K, Hoshi H, Onozuka M, Nozaki A, Hirano M, Shiratori Y, Moriyama N.
  • Journal Title: (in press) Pages: 2006-2006
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Multi-Detector Row CT of the Liver and Hypervascular Hepatocellular Carcinomas : Optimizing Scan Delays for Bolus Tracking Techniques of Hepatic Arterial and Portal Venous Phases. (2006)
  • Author(s): Goshima S, Kanematsu M, Kondo H, Yokoyama R, Miyoshi Y, Nishibori H, Kato H, Hoshi H, Onozuka M, Moriyama N.
  • Journal Title: Am J Roentgenol (in press) Pages: 2006-2006
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Expression of vascular endothelial growth factor in hepatocellular carcinoma and the surrounding liver : correlation with MR imaging and angiographically assisted CT. (2006)
  • Author(s): Kanematsu M, Osada S, Amaoka N, Goshima S, Kondo H, Moriyama N.
  • Journal Title: Abdom Imaging 31 Pages: 78-89
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] High-Spatial-Resolution Gadolinium-Enhanced Double Hepatic Arterial-Phase MR Imaging of the Liver with Reversed Centric and Centric K-Space Reordering Switching. (2006)
  • Author(s): Kanematsu M, Goshima S, Kondo H, Yokoyama R, Kajita K, Hoshi H, Onozuka M, Nozaki A, Hirano M, Shiratori Y, Moriyama N.
  • Journal Title: Am J Roentgenol (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Magnetic Resonance Imaging and Expression of Vascular Endothelial Growth Factor in Hepatocellular Nodules in Cirrhosis and Hepatocellular Carcinomas. (2005)
  • Author(s): Kanematsu M, Semelka RC, Osada S, Amaoka N.
  • Journal Title: Top Magn Reson Imaging 16 Pages: 67-75
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Evaluation of extracellular signal regulated kinase expression and its relation to treatment of hepatocellular carcinoma. (2005)
  • Author(s): Osada S, Kanematsu M, Imai H, Goshima S, Sugiyama Y.
  • Journal Title: J Am Coll Surg 201 Pages: 405-411
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Optimizing scan delays of fixed duration contrast injection in contrast-enhanced biphasic multidetector-row CT for the liver and the detection of hypervascular hepatocellular carcinoma. (2005)
  • Author(s): Kanematsu M, Goshima S, Kondo H, Nishibori H, Kato H, Yokoyama R, Miyoshi T, Hoshi H, Onozuka M, Moriyama N.
  • Journal Title: J Comput Assist Tomogr 29 Pages: 195-201
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Expression of vascular endothelial growth factor in hepatocellular carcinoma and the surrounding liver and correlation with MRI findings. (2005)
  • Author(s): Kanematsu M, Osada S, Amaoka N, Goshima S, Kondo H, Kato H, Nishibori H, Yokoyama R, Hoshi H, Moriyama N.
  • Journal Title: Am J Roentgenol 184 Pages: 832-841
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Does T2-weighted MR imaging improve preoperative detection of malignant hepatic tumors? Observer performance study in 49 surgically proven cases. (2005)
  • Author(s): Kondo H, Kanematsu M, Itoh K, Ito K, Maetani Y, Goshima S, Matsuo M, Matsunaga N, Konishi J, Hoshi H, Moriyama N.
  • Journal Title: Magn Reson Imaging 23 Pages: 89-95
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Solitary mediastinal lymph node metastasis of hepatocellular carcinoma : MR imaging findings. (2005)
  • Author(s): Tanaka O, Kanematsu M, Kondo H, Goshima S, Nishibori H, Kato H, Kiryu T, Yokoyama R, Hoshi H, Moriyama N.
  • Journal Title: Magn Reson Imaging 23 Pages: 111-114
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Does T2-weighted MR imaging really add no value in detection and characterization of focal lesions in cirrhotic liver? (2005)
  • Author(s): Kanematsu M, Goshima S.
  • Journal Title: Radiology 234 Pages: 638-640
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Magnetic Resonance Imaging and Expression of Vascular Endothelial Growth Factor in Hepatocellular Nodules in Cirrhosis and Hepatocellular Carcinomas. (2005)
  • Author(s): Kanernatsu M, Semelka RC, Osada S, Amaoka N.
  • Journal Title: Top Magn Reson Imaging 16 Pages: 67-75
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Expression of vascular endothelial growth factor in hepatocellular carcinoma and the surrounding liver and correlation with MRI findings. (2005)
  • Author(s): Kanematsu M, Osada S, Amaoka N, Goshima S, Kondo H, Kato H, Nishibori H, Yokoyama R, Hoshi H, Moriyama N.
  • Journal Title: Am J Roentgenol 182 Pages: 832-841
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Does T2-weighted MR imaging improve preoperative detection of malignant hepatic tumors? Observer performance study in 49 surgically proven cases. (2005)
  • Author(s): Kondo H, Kanematsu M, Ito K, Ito K, Maetani Y, Goshima S, Matsuo M, Matsunaga N, Konishi J, Hoshi H, Moriyama N.
  • Journal Title: Magn Reson Imaging 23 Pages: 89-95
• [Journal Article] Expression of vascular endothelial growth factor in hepatocellular carcinoma and the surrounding liver and correlation with MRI findings (2005)
  • Author(s): Masayuki Kanematsu, 他
  • Journal Title: American Journal of Roentgenology 184 Pages: 832-841
• [Journal Article] 肝細胞癌の血管新生:動注CT,MRIとVEGF活性 (2005)
  • Author(s): 兼松雅之, 他
  • Journal Title: 肝細胞癌:発癌・血管新生と血流イメージング 単行本 Pages: 14-23
• [Journal Article] Expression of vascular endothelial growth factor in hepatocellular carcinoma and the surrounding liver : correlation with angiographically assisted CT. (2004)
  • Author(s): Kanematsu M, Osada S, Amaoka N, Goshima S, Kondo H, Nishibori H, Kato H, Matsuo M, Yokoyama R, Hoshi H, Moriyama N.
  • Journal Title: Am J Roentgenol 183 Pages: 1585-1593
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Angiogenesis in hepatocellular nodules : Correlation of MR imaging and vascular endothelial growth factor. (2004)
  • Author(s): Kanematsu M, Semelka RC, Leonardou P, Mastropasqua M, Armao D, Vaidean G, Firat Z, Woosley JT.
  • Journal Title: J Magn Reson Imaging 20 Pages: 426-434
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Expression of vascular endothelial growth factor in hepatocellular carcinoma and the surrounding liver : correlation with angiographically assisted CT. (2004)
  • Author(s): Kanematsu M, Osada S, Amaoka N, Goshima S, Kondo H, Nishibori H, Kato H, Matsuo M, Yokoyama R, Hoshi H, Moriyama N.
  • Journal Title: Am J Roentgenol 182 Pages: 1585-1593
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Expression of vascular endothelial growth factor in hepatocellular carcinoma and the surrounding liver : correlation with angiographically assisted CT (2004)
  • Author(s): Masayuki Kanematsu, 他
  • Journal Title: American Journal of Roentgenology 183 Pages: 1585-1593