| Project/Area Number |
16591203
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kyoto University |
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Principal Investigator |
SHIBATA Toshiya Kyoto Univ., Graduate School of Medicine, Associate Professor, 医学研究科, 助教授 (60162632)
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| Co-Investigator(Kenkyū-buntansha) |
HATANO Etsuo Kyoto Univ., Graduate School of Medicine, Assistant Professor, 医学研究科, 助手 (80359801)
IKAI Iwao Kyoto Univ., Graduate School of Medicine, Associate Professor, 医学研究科, 助教授 (60263084)
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| Project Period (FY) |
2004 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2006: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2005: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2004: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | Tumor ablation / radiofrequency / liver tumor / Tumor ablation / radiofrequency / liver tumor / RF ablation / saline enhance / Cool-tip electrode / 肝細胞癌 |
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| Research Abstract |
Saline-enhanced RF ablation is a new procedure to obtain larger coagulation area, injecting physiologic saline drop by drop through the side holes of the electrode into tumor tissues during the RF ablation. We performed saline-enhanced RF ablation for ex-vivo liver parenchyma with Elektrotom 106 HITT (Berchtold) which is commercially available in Europe, but unexpected, undesirable large area was coagulated. So, we believe the clinical application of the Elektrotom 106 HITT to patients might be not safe. We performed RF ablation with a widely-used Cool-tip electrode, injecting 5-ml saline with two to four PEIT needles placing 1-2cm around the Cool-tip electrode, and obtained large coagulation areas around the electrode. Then, seven cases (age; 60-76 years, man/woman; 5/2) with 2.5-5.2cm hepatocellular carcinoma (HCC) was treated with this saline-enhanced RF technique. Good clinical results; complete treatment effects and no local tumor progression were obtained. In the future, we would like to treat a HCC nodule larger than 5cm, using this saline-enhanced technique.
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