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Increasing stent system for TIPS : in vitro study

Research Project

Project/Area Number 16591230
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionNihon University

Principal Investigator

TAKAHASHI Motoichiro  Nihon University, Department of Radiology, Professor, 医学部, 教授 (20115489)

Co-Investigator(Kenkyū-buntansha) HIMI Kazuhisa  Nihon University, Department of Radiology, M.D., Associate professor, 医学部, 助教授 (10156614)
YOSHINOBU Takashi  Nihon University, Department of Radiology, Assistant professor, 医学部, 助手 (00191635)
FURUHASHI Satoru  Nihon University, Department of Radiology, Assistant professor, 医学部, 助手 (70318434)
ISODA Haruo  Hamamatsu University School of Medicine, Department of Radiology, Associate professor, 医学部, 助教授 (40223060)
INAGAWA Shoichi  Hamamatsu University School of Medicine, Department of Radiology, Assistant professor, 医学部, 講師 (60303567)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 2005: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2004: ¥1,100,000 (Direct Cost: ¥1,100,000)
KeywordsMetallic Sten / TIPS / Hepatic failure / in vitro studies / MRI flow measurement / 血管ファントム / 肝性腫瘍 / ウォールステント / 血管モデル
Research Abstract

Transjugular intrahepatic portosystemic shunt (TIPS) is an effective portal decompression therapy for the cirrhotic patient with portal hypertensive gastroenteropathy, intractable varix or massive ascites. However, portosystemic overshunting often brought troublesome complication of hepatic failure or hepatic encephalopathy after the TIPS making. To avoid the irreversible overshunting is especially essential in TIPS procedure because most patients with hepatic cirrhosis have atrophic process of the liver in Japan. The aim of our study is to make a newly designed "increasing stent system" which is able to elevate portosystemic shunt flow gradually in the TIPS route. Using a silk suture, we made two kinds of tied bare (Wallstent RP, 10mm x 49mm, Boston Scientific) and covered stent (Niti-STMCom Vi Stent, 10mm x 5cm, CMI Century Medical) having stenotic segment(s). The stenotic bare or covered stent was intentionally able to dilate by means of cutting the tied suture using a PTA cutting balloon catheter (Boston Scientific). In vitro MR studies on flow dynamics using a handmade vascular phantom was then carried out. Flow measurement was made in 2D cine phase contrast MRI. MRI parameters were set as follows ; TR/TE/NEX=29/5/1, FA=33 degrees, Band width=31.25kHz, FOV=10 x 10cm, Matrix=128 x 128, Slice thickness=4mm, VENC=60cm/s, imaging time=1min20sec. These studies demonstrated marked decrease of flow velocity and flow volume at the placement of modified stenotic covered stent, and no remarkable flow change at the deployment of modified stenotic bare stent. Making a so called "increasing stent system"was suggested from these in vitro studies. Further in vivo animal studies would be recommended before the clinical application of the "increasing stent system" in TIPS procedure.

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (5 results)

All 2005

All Journal Article (5 results)

  • [Journal Article] Increasing stent の in vitro での基礎的研究 第1報 modified bare stent の実験2005

    • Author(s)
      高橋元一郎, 古橋 哲, 吉信 尚, 氷見和久, 磯田治夫, 稲川正一
    • Journal Title

      第11回日本血管内治療学会総会 プログラム・抄録集

      Pages: 70-70

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Increasing stent の in vitro での基礎的研究 第2報 modified covered stent の血流変化に関するMR血管ファントム実験2005

    • Author(s)
      古橋 哲, 高橋元一郎, 吉信 尚, 石橋直也, 福島祥子, 磯田治夫, 稲川正一
    • Journal Title

      日本画像医学誌 24・2

      Pages: 104-104

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Increasing stent system for TIPS.2005

    • Author(s)
      Takahashi M. et al.
    • Journal Title

      The 1^<st> report of comparative studies of modified bare stent and modified covered stent at the annual meeting of the Japanese Society for Endovascular Intervention. July, Tokyo (Abstract)

      Pages: 70-70

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Increasing stent system for TIPS.2005

    • Author(s)
      Furuhashi Satoru, Motoichiro Takahashi, et al.
    • Journal Title

      The 2^<nd> report on MR vascular phantom studies of modified covered stent at the Japanese Society for Medical Imaging. February 2006, Tokyo(Jpn.J.Med.Imaging) 24(2)

      Pages: 104-104

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Increasing Stent systemのin vitroでの基礎的研究 第2報 modified covered stentの血流変化に関するMR血管ファントム実験2005

    • Author(s)
      古橋 哲, 高橋元一郎, 他
    • Journal Title

      日本画像医学誌 24・2

      Pages: 104-104

    • Related Report
      2005 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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