Enhancement of Immunological Activity and drug Uptake to Tumor by Mild-Hyperthermia.
| Project/Area Number |
16591234
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Suzuka University of Medical Science |
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Principal Investigator |
HASEGAWA Takeo Suzuka University of Medical Science, Faculty of Health Science, Professor, 保健衛生学部, 教授 (80077784)
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| Co-Investigator(Kenkyū-buntansha) |
GU YeunHwa Suzuka University of Medical Science, Faculty of Health Science, Professor, 保健衛生学部, 教授 (40298667)
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2005: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 2004: ¥3,000,000 (Direct Cost: ¥3,000,000)
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| Keywords | Mild Hyperthermia / Immunological Activity / Increased of Blood Flow / Drug Uptake / Anti-Tumor Effect / 化学療法 / シスプラチン / 血管拡張 / 薬剤取込み増加 / アポトーシス / NK細胞活性 |
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| Research Abstract |
In general, hyperthermia (HT) therapy is performed at a temperature of 42.5℃ for 1 hour. It is believed that mild HT at 39℃ to 40℃ brings no anti-tumor effects in the in vitro system. But in the present study, we found that there were anti-tumor effects even when at a temperature of 39℃ to 40℃ in vivo due to activation of immunological status. The tumor cells were transplanted on the right thigh of mice. HT was brought by giving a heat to the right thigh in a controlled water bath at 39℃ to 40℃ for 1 hour. After giving the mild HT, NK cells activity and the numbers of white blood cells, lymphocyte cells, granulocyte, and monocyte increased transiently in comparison with those in the pre-heated condition. A delay in SCC-VII tumor growth in C3H mice and a failure in the implantation of tumor were also observed after the mild HT. The chemotherapy combined with mild-HT were increased the anti-tumor effect due to the increase of drug uptake into the tumor tissues. HT were carried out at 41
… More
degree for 30 min and combined with cisplatin (7mg/kg, IP) as anti-cancer drug. But combined with mild-HT were 7-times of drug concentration higher than drug alone group in the tumor tissues. When combined with mild-TH and chemotherapy, tumor growth delay were significantly increased combined with heat alone or drug alone treatment. The HT has effect of enhanced the permeability of the cell membrane. These results suggest that HT has effect of increase of blood flow due to the vasodilatation and cell membrane were changed to high permeability of the drug due to the reduced the function of ion channels. Therefore, the chemotherapy may reduced the drugs using mild-HT and it can be reduced the side effects for treatment of tumor on clinically. Mild HT seems to be a useful and effective auxiliary therapy which is not only effective for the treatment of malignant tumors but also for the treatment of diseases related to immunological disturbances such as hepatitis type C, AIDS etc because of no any side effects. And HT has effects of vessel dilatation and increased a blood flow in the heating areas. Less
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Report
(3 results)
Research Products
(25 results)
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[Journal Article] Embryonic Death Effects of Hyperthermia Induced by RF(Radiofrequency) Waves.2006
Author(s)
Young-Nam Kang, Toshihiro Maenaka, Yuka Itokawa, Takenori Yamashita, Takashi Nakamura, Masami Oshima, Takeo Hasegawa, Ikukatsu Suzuki, Kaori Tano, Torao Ishida, YeunHwa Gu.
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Journal Title
Medicine and Biology. Vol.150, No.3
Pages: 97-103
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] The Activation of Immunological Activity and Anti-tumor Effects by Mild-Hyperthermia.2005
Author(s)
Katsuyiki Miyata, Takeo Hasegawa, Kayoko Maeda, Satoshi Ando, Morikazu Amano, Atsushi Fukuyama, Hajime Monzen, YeunHwa Gu, Tohru Takahashi, Itsuo Yamamoto.
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Journal Title
JPN, Journal of Hyperthermic Oncology. Vol.21, No.1
Pages: 33-45
NAID
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Combination of Administration of Arsenic Trioxide and Hyperthermia.2005
Author(s)
Tomokuni Suzuki, Hajima Monzen, Jun Kouda, Yuuichi Namoto, Morikazu Amano, Hirobumi Ono, Yukiko Ohno, Kayoko Maeda, Atsushi Fukuyama, Satoshi Ando, Tohru Takahashi, Itsuo Yamamoto, Takeo Hasegawa.
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Journal Title
JPN.Journal of Hyperthermic Oncology. Vol.21, No.2
Pages: 103-112
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] Non-Invasive Measurement of the Temperature Using Scanning Small Coils.2004
Author(s)
Satoshi Ando, Hajime Monzen, Morikazu Amano, Hirobumi Ono, Tomoaki Suzuki, Kayoko Maeda, Atsushi Fukuyama, Tohru Takahashi, Itsuo Yamamoto, Takeo Hasegawa
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Journal Title
JPN, Journal of Hyperthermic Oncology. Vol.20, No.4
Pages: 249-255
NAID
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Effects of Ganoderma Lucidum on Immunocompetence in Mice.
Author(s)
Young-Nam Kang, Yoka Itokawa, Toshihiro Maenaka, Takenori Yamashita, Takashi Nakamura, Takeo Hasegawa, In-Sook Choli, Kaori Tno, Torao Ishida, YeunHwa Gu.
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Journal Title
Medicine and Biology Vol.150, No.2
Pages: 90-96
Description
「研究成果報告書概要(欧文)」より
Related Report
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