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Immunotherapy of carcinomatous pleuritis and peritonitis targeting phosphoglucose isomerase as a vaccine.

Research Project

Project/Area Number 16591246
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionGunma University

Principal Investigator

TSUTSUMI Soichi  Gunma University, Graduate School of Medicine, Assistant Professor (30323356)

Co-Investigator(Kenkyū-buntansha) ASAO Takayuki  Gunma University, Graduate School of Medicine, Associate Professor (40212469)
KUWANO Hiroyuki  Gunma University, Graduate School of Medicine, Professor (90186560)
Project Period (FY) 2004 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,850,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2006: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2005: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2004: ¥1,500,000 (Direct Cost: ¥1,500,000)
KeywordsAutocrine motility factor / colorectal cancer / Liver metastasis / 膵臓癌
Research Abstract

The progression and metastasis of cancer are controlled by extracellular growth factors and cytokines. PGI (EC 5. 3. 1. 9) is a ubiquitous cytosolic enzyme that catalyzes the second step in glycolysis. Molecular cloning and sequencing have identified PGI as a motility factor. I.e., autocrine motility factor (AMF), also known as and neuroleukin or maturation factors. AMF/PGI is also a multifunctional cytokine that exhibits multifunctional growth factor-like activity via a unique cognate 78 kDa (gp78) seven-transmembrane glycoprotein receptor (autocrine motility factor receptor, AMFR). We have shown that the overexpression of AMF/PGI enhances cell proliferation together with up-regulation of cyclin/cyclin-dependent kinase activities and down-regulation of p27^<Kip1>. Overexpression of AMF/PGI and AMFR has been found in a wide spectrum of malignancies and is associated with cancer progression, metastasis, and angiogenesis.
The goal of cancer therapy remains as the long-term eradication of … More tumor cells without adverse effects on normal tissue. Conventional approaches utilizing chemotherapy and radiotherapy are limited by both their toxicity and lack of specificity. In recent years, investigators have carried out several studies designed to evaluate whether human tumor-associated antigens can be exploited as targets for immunotherapy, specifically for human cancer vaccine development A major limitation in immunotherapy studies of human cancer is the general lack of appropriate preclinical models. Clinical studies can be difficult to implement, particularly when a clear understanding of the potential efficacy, limitation, and safety of an immunotherapeutic strategy is not available from relevant animal investigations. In this study, we assessed whether overexpression of PGI in human cancer cells enhances the liver metastasis using a mouse model. We also investigated the intracellular signal transduction pathways of PGI in human cancer cell lines. In vivo, after implantation into the nude mice, control cells produced locally relatively small tumors with no evidence of liver metastasis, whereas PGI-transfected cells produced the large tumors and liver metastases. The data submitted here show that PGI expression significantly contributes to the aggressive phenotype of human cancer. Thus, PGI may serve as an important and widely applicable target for anti-cancer immunotherapeutic strategies. Less

Report

(5 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (37 results)

All 2007 2006 2005 2004

All Journal Article (28 results) (of which Peer Reviewed: 11 results) Presentation (9 results)

  • [Journal Article] Regulation of phosphoglucose isomerase/autocrine motility factor activities by the poly (ADP-ribose) polymerase family-14.2007

    • Author(s)
      Yanagawa T, Funasaka T, Tsutsumi S, Hu H, Watanabe H, Raz A.
    • Journal Title

      Cancer Research 67

      Pages: 8682-8689

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 外来がん化学療法のリスクマネジメント2007

    • Author(s)
      堤 荘一, 浅尾高行, 桑野博行
    • Journal Title

      臨床外科 62

      Pages: 613-7

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Regulation of phosphoglucose isomerase/autocrine motility factor activities by the poly(ADP-ribose) polymerase family-142007

    • Author(s)
      Yanagawa T, Funasaka T, Tsutsumi S, Hu H, Watanabe H, Raz A.
    • Journal Title

      Cancer Research 67

      Pages: 8682-8689

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Management system of cancer chemotherapy for outpatients2007

    • Author(s)
      Tsutsumi s, Asao T., Kuwano H.
    • Journal Title

      Journal of Clinical Surgery 62

      Pages: 613-617

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Diagnosis and Treatment of Peritoneal Dissemination of Colorectal Cancer2007

    • Author(s)
      Tsutsumi s, Asao T., Kuwano H.
    • Journal Title

      Journal of Clinical Surgery 62

      Pages: 613-617

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Regulation of photophoglucose isomerase/autocrine motility factor activities by the poly(ADP-ribose) polymerase family-142007

    • Author(s)
      Yanagawa T., Funasaka T, Tsutsumi S, Hu H, Watanabe h, Raz A.
    • Journal Title

      Cancer Reasearch 67

      Pages: 8682-8689

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] colonoscopy using an abdominal bandage2007

    • Author(s)
      Tsutsumi S, Fukushima H, Kuwano H.
    • Journal Title

      Hepatogastroenterology 54

      Pages: 1983-1984

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Feasibility of colonoscopy in patients 80 of age and older2007

    • Author(s)
      Tsutsumi S, Fukushima H, Osaki K, Kuwano H.
    • Journal Title

      Hepatogastroenterology 54

      Pages: 1959-1961

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Over-expression of 14-3-3sigman in budding colorectal cancer cells modulates cell migration in the presence of tenascin-C2007

    • Author(s)
      Ide M, Saito K, Tsutsumi S, Tsuboi K, Yamaguchi S, Asao T, Kuwano H, Nakajima T.
    • Journal Title

      Oncology Report 18

      Pages: 1451-1456

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Asao T, Yamaguchi S, Tsutsumi S, Mochiki E, Kuwano H. Exprimental results and early clinical experience with an easy method for intracorporeal knot tying using a novel with an easy method for intracorporeal knot tying using a novel laparoscopic needleholder2007

    • Author(s)
      Asao T, Yamaguchi S, Tsutsumi S, Mochiki E, Kuwano H.
    • Journal Title

      Surg Endosc 9

      Pages: 1553-1556

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Galectin-3 expression in colorectal cancer. relation to invasion and metatasis2007

    • Author(s)
      Tsuboi K, Shimura T, Masuda n, Ide M. Tsutsumi S, Yamaguchi S, Asao T, Kuwano H.
    • Journal Title

      Anticancer Reasrerch 27

      Pages: 2289-2296

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect if basic fibroblast growth factor,trafermin,on entero-related fistulae, report of two casses2007

    • Author(s)
      Yamaguchi S, Asao Tm Nakamura J, Tsuboi K, Tsutsumi S, Kuwano H.
    • Journal Title

      Hepatogastroenterology 54

      Pages: 803-805

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 外来がん化学療法のリスクマネジメント2007

    • Author(s)
      堤 荘一, 浅尾 高行, 桑野 博行
    • Journal Title

      臨床外科 62

      Pages: 613-617

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 群馬大学医学部附属病院の外来化学療法2006

    • Author(s)
      堤荘一, 浅尾高行, 桑野博行
    • Journal Title

      癌と化学療法 33

      Pages: 1358-1359

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 大腸癌腹膜播種の診断と治療2006

    • Author(s)
      堤荘一, 浅尾高行, 桑野博行
    • Journal Title

      臨床外科 61

      Pages: 775-778

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Outpatient chemotherapy in Gunma University Hospital2006

    • Author(s)
      Tsutsumi s, Asao T., Kuwano H.
    • Journal Title

      Japanese Journal of Cancer and Chemotherapy 33

      Pages: 1358-1359

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Second-line combination chemotherapy of oral S-1 with cisplatin and irinotecan for colorectal cancer resistant to 5・FU.2006

    • Author(s)
      Tsutsumi S, Kuwano H, Asao T
    • Journal Title

      Hepatogastroenterology 53・68

      Pages: 196-200

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Oral regimen consisting of UFT/UZEL for elderly patients with colorectal cancer.2006

    • Author(s)
      Tsutsumi S, Kuwano H, Asao T
    • Journal Title

      Hepatogastroenterology 53・68

      Pages: 209-212

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Anxiety in outpatients receiving chemotherapy for solid cancer.2006

    • Author(s)
      Tsutsumi S, Kuwano H, Asao T
    • Journal Title

      Hepatogastroenterology 53・72

      Pages: 828-830

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The synchronization of chemotherapy to circadian rhythms and irradiation in pre-operative chemoradiation therapy with hvperthermia for local advanced rectal cancer.2006

    • Author(s)
      Asao T, Tsutsumi S, Kuwano H
    • Journal Title

      Int J Hyperthermia 22・5

      Pages: 399-406

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Implication of galectin-3 in Wnt signaling2005

    • Author(s)
      Shimura T, Tsutsumi S, Kuwano H
    • Journal Title

      Cancer Research 65

      Pages: 3535-3537

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Ets-1 expression in gastric cancer2005

    • Author(s)
      Tsutsumi S, Kuwano H, Asao T.
    • Journal Title

      Hepatogastroenterology. 52

      Pages: 654-656

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Vascular endothelial growth factor C(VEGF-C)expression in pT2 gastric cancer2005

    • Author(s)
      Tsutsumi S, Kuwano H, Asao T.
    • Journal Title

      Hepatogastroenterology. 52

      Pages: 629-632

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Loss of KAI1 expression in gastric cancer2005

    • Author(s)
      Tsutsumi S, Kuwano H, Asao T.
    • Journal Title

      Hepatogastroenterology. 52

      Pages: 281-284

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Differential regulation of phosphoglucose isomerase/autocrine motility factor activities by protein kinase CK2 phosphorylation2005

    • Author(s)
      Yanagawa T, Tsutsumi S
    • Journal Title

      J Biol Chem 280

      Pages: 10419-10426

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Autocrine Motility Factor Signaling Enhances Pancreatic Cancer Metastasis2004

    • Author(s)
      Soichi Tsutsumi, Hiroyuki Kuwano
    • Journal Title

      Clinical Cancer Research 10

      Pages: 7775-7784

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Cell density modulates the metastatic aggressiveness of a mouse colon cancer cell line, colon 262004

    • Author(s)
      Hiroyuki Kuwano, Asao T, Tsutsumi S.
    • Journal Title

      Oncology 67(5-6)

      Pages: 441-449

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Malignant transformation of the mouse anorectal epithelium induced by an inoculated human cancer cell line.2004

    • Author(s)
      Hiroyuki Kuwano, Asao T, Tsutsumi S.
    • Journal Title

      Dig Dis Sci. 49(11-12)

      Pages: 1912-1921

    • Related Report
      2004 Annual Research Report
  • [Presentation] 大学病院での緩和医療とその問題点2007

    • Author(s)
      堤荘一, 山口悟, 坪井香保里, 深澤孝晴, 田部雄一, 浅尾高行, 桑野博行
    • Organizer
      第43回日本腹部救急医学会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-07-18
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Pain and palliative care in Gunma University Hospital2007

    • Author(s)
      Tsutsumi S., Yamaguchi S., Tsuboi K., Fukasawa T., Asao T., Kuwano H
    • Organizer
      The 62nd Annual Meeting of the Japanese Society of Gastroenterological Surgery
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-07-18
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 大学病院での緩和医療とその問題点2007

    • Author(s)
      堤 荘一, 山口 悟, 坪井 香保里, 深澤 孝晴, 田部 雄一, 浅尾 高行, 桑野 博行
    • Organizer
      第62回日本消化器外科学会定期学術集会
    • Place of Presentation
      東京
    • Year and Date
      2007-07-18
    • Related Report
      2007 Annual Research Report
  • [Presentation] mFOLFOX6のL-OHP中断症例の検討2007

    • Author(s)
      堤 荘一、浅尾高行、桑野博行
    • Organizer
      第93回日本消化器病学会総会
    • Place of Presentation
      青森
    • Year and Date
      2007-04-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Stop and Go strategy of FOLFOX6 regimen in Colorectal cancer chemotherapy2007

    • Author(s)
      Tsutsumi S., Yamaguchi S., Tsuboi K., Fukasawa T., Asao T., Kuwano H.
    • Organizer
      The 93rd Annual Meeting of the Japanese Society of Gastroenterology
    • Place of Presentation
      Aomori
    • Year and Date
      2007-04-19
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 大腸癌に対する腹腔鏡補助下手術と小開腹手術の使い分けに関するストラテジー2007

    • Author(s)
      堤 荘一, 山口悟, 坪井香保里, 深澤孝晴, 田部雄一, 浅尾高行, 桑野博行
    • Organizer
      第107回日本外科学会定期学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2007-04-13
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Strategy of Surgical Treatment for Colorectal Cancer2007

    • Author(s)
      Tsutsumi S., Yamaguchi S., Tsuboi K., Fukasawa T., Asao T., Kuwano H.
    • Organizer
      The 107th Annual Congress of Japanese Surgical Society
    • Place of Presentation
      Osaka
    • Year and Date
      2007-04-13
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 救命しえた門脈ガス血症を呈した非閉塞性腸管梗塞症の一症例2007

    • Author(s)
      堤荘一, 山口悟, 坪井香保里, 深澤孝晴, 浅尾高行, 桑野博行
    • Organizer
      第43回日本腹部救急医学会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-03-08
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Successful treatment of Nonocclusive ischemia of the right colon2007

    • Author(s)
      Tsutsumi S., Yamaguchi S., Tsuboi K., Fukasawa T., Asao T., Kuwano H.
    • Organizer
      The 43rd Annual Congress of Japanese Society for Abdominal Emergency Medicine
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-03-08
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2004-04-01   Modified: 2016-04-21  

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