• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The role of Stat5 for targeting therapy and chemoprevention in breast cancer

Research Project

Project/Area Number 16591267
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionNAGOYA CITY UNIVERSITY

Principal Investigator

YAMASHITA Hiroko  Nagoya City University, Graduate School of Medical Sciences, Associate Professor, 大学院・医学研究科, 助教授 (70332947)

Co-Investigator(Kenkyū-buntansha) HAMAGUCHI Maho  Nagoya City University, Graduate School of Medical Sciences, Research Fellow, 大学院・医学研究科, 臨床研究医 (70381845)
MITA Keiko  Nagoya City University, Graduate School of Medical Sciences, Research Fellow, 大学院・医学研究科, 研究員 (70381895)
IWASE Hirotaka  Kumamoto University, Faculty of Medical and Pharmaceutical Sciences, Professor, 医学薬学研究室, 教授 (40211065)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2005: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2004: ¥2,600,000 (Direct Cost: ¥2,600,000)
Keywordsbreast cancer / Stat5 / targeting therapy
Research Abstract

Constitutively activated signal transducers and activators of transcription (Stats), in particular Stat3 and Stat5, have been demonstrated to directly contribute to oncogenesis by stimulating cell proliferation and preventing apoptosis in various cancers. Stat3 is essential in mammary gland epithelial cell apoptosis and involution, whereas Stat5 is well established as a key factor in mammary epithelial cell growth and differentiation. Crosstalk between Stats and estrogen receptor (ER) has been demonstrated by several laboratories and we have focused on the role of Stat5 in ER-positive breast cancer. Using immunohistochemical techniques, we examined expression of Stat3 and Stat5 in 517 human breast cancer tissues and analyzed their significance for prognosis and prediction of response to endocrine therapy. Stat5 expression was significantly correlated with histological grade (P<0.0001), ER (P=0.02), and progesterone receptor (PR)(P=0.026) expression. There was no difference between Stat3 expression and clinicopathological factors. In 346 patients with ER-positive breast cancer, patients with Stat5 positive tumors had significantly increased overall survival (P=0.0009) in multivariate analysis. There were 70 patients who received endocrine therapy as first-line treatment for metastatic breast cancer at relapse. The patients whose primary breast tumors were Stat5 positive had significantly better response to endocrine therapy (P=0.04), and longer survival after relapse (P= 0.0003), that those whose tumors were Stat5 negative. The present study demonstrates for the first time that Stat5 is a predictive factor for endocrine therapy response and a strong prognostic molecular marker in ER-positive breast cancer. Our data suggest that expression of Stat5 is helpful in selecting patients who may benefit from endocrine therapy.

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (8 results)

All 2006 2005 2004 Other

All Journal Article (8 results)

  • [Journal Article] Immunohistochemical evaluation of hormone receptor status for predicting response to endocrine therapy in metastatic breast cancer.2006

    • Author(s)
      Hiroko Yamashita
    • Journal Title

      Breast Cancer 13

      Pages: 74-83

    • NAID

      10017238839

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Immunohistochemical evaluation of hormone receptor status for predicting response to endocrine therapy in metastatic breast cancer.2006

    • Author(s)
      Yamashita H, et al.
    • Journal Title

      Breast Cancer 13

      Pages: 4-83

    • NAID

      10017238839

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Phosphorylation of estrogen receptor α serine 167 is predictive of response to endocrine therapy and increases postrelapse survival in metastatic breast cancer.2005

    • Author(s)
      Hiroko Yamashita
    • Journal Title

      Breast Cancer Res 7

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Phosphorylation of estrogen receptor α serine 167 is predictive of response to endocrine therapy and increases postrelapse survival in metastatic breast cancer.2005

    • Author(s)
      Yamashita H, et al.
    • Journal Title

      Breast Cancer Res 7

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Phosphorylation of estrogen receptor a serine 167 is predictive of response to endocrine therapy and increases postrelapse survival in metastatic breast cancer.2005

    • Author(s)
      Hiroko Yamashita
    • Journal Title

      Breast Cancer Res 7

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Dominant-negative Stat5 inhibits growth and induces apoptosis in T47D-derived tumors in nude mice.2004

    • Author(s)
      Hiroko Yamashita
    • Journal Title

      Cancer Science 95・8

      Pages: 662-665

    • NAID

      10013570427

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Stat5 expression predicts response to endocrine therapy and improves survival in estrogen receptor-positive breast cancer.

    • Author(s)
      Hiroko Yamashita
    • Journal Title

      Endocr-Relat Cancer (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Stat5 expression predicts response to endocrine therapy and improves survival in estrogen receptor-positive breast cancer.

    • Author(s)
      Yamashita H, et al.
    • Journal Title

      Endocr-Relat Cancer (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary

URL: 

Published: 2004-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi