Pathological evaluation for long-term renal graft survival-Comparison with regulatory T cells
| Project/Area Number |
16591268
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
OKAMOTO Masahiko Kyoto Prefectural University of Medicine, School of Medicine, Associate Professor, 医学部, 助教授(寄附講座) (90295650)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIMURA Norio Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Professor, 医学研究科, 教授 (00191643)
AKIOKA Kiyokazu Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Assistant Professor, 医学研究科, 助手 (80326222)
KAIHARA Satoshi Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Associate Professor, 医学研究科, 助教授 (70324647)
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2005: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2004: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | renal transplantation / biopsy / calcineurin inhibitor |
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| Research Abstract |
10-year protocol biopsies have been performed in sixteen patients treated with Calcineurin inhibitor(CNI) continuously. All kidney grafts were functioning well at the time of biopsy with the mean serum creatinine level of 1.6±0.8mg/dl. The specimen of biopsy showed various degrees of tissue injury. According to the Banff grading, allograft glomerulopathy(cg) was observed in one case. Interstitial fibrosis(ci) and tubular atrophy(ct) were observed more frequently in thirteen(81%) and fifteen(93%) cases, respectively. Fibrous intimal thickening(cv) was seen in one(7%) case. Arteriolar hyaline thickening(ah) was seen in fourteen(87%) cases. These findings were associated with chronic rejection in one case, recurrence of original disease in four(25%) cases, toxicity of CNI in fourteen (87%) cases. Longer follow up studies are needed to confirm whether CNI should be continued or not in long-term period following kidney transplantation for better graft survival.
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Report
(3 results)
Research Products
(10 results)
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[Journal Article] 10-year protocol biopsy findings of renal allografts in calcineurin inhibitor era
Author(s)
Masahiko Okamoto, Kiyokazu Akioka, Hidetaka Ushigome, Atsushi Higuchi, Shuji Nobori, Shiro Ogino, Kenji Uryuhara, Satoshi Kaihara, Tsuguru Hatta, Koji Urasaki, Norio Yoshimura
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Journal Title
Clinical Transplantation (in press)
Description
「研究成果報告書概要(欧文)」より
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