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Study of drug sensitivity to molecular targeting drugs in breast cancer

Research Project

Project/Area Number 16591282
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionKurume University

Principal Investigator

FUJII Teruhiko  Kurume University, Medical School, Associate Professor, 医学部, 助教授 (50199288)

Co-Investigator(Kenkyū-buntansha) YOKOYAMA Goro  Kurume University, Medical School, Research Associate, 医学部, 助手 (00309808)
YAMAGUCHI Miki  Kurume University, Medical School, Research Associate, 医学部, 助手 (70330834)
KUWANO Michihiko  Kurume University, Medical School, Professor, 医学部, 教授 (80037431)
Project Period (FY) 2004 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2006: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2005: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2004: ¥1,200,000 (Direct Cost: ¥1,200,000)
Keywordsbreast cancer / YB-1 / Cap43 / ER-α / Akt / HER2 / NDRG1 / ER / 薬剤耐性
Research Abstract

1. Expression of nuclear YB-1 thus may play an essential role in acquirement of malignant characteristics through HER2-Akt dependent pathways in breast cancer patients. Nuclear YB-1 localization would thus be expected to be molecular target of intrinsic importance not only for acquirement of multidrug resistance but also for tumor growth dependent upon HER2 and estrogen receptor.
2. Estradiol-induced down-regulation of Cap43 gene thus appeared to be mediated through ER-α dependent pathway in breast cancer cells in culture and in patients. Cap43 will be a molecular marker useful for determination of the therapeutic efficacy of anti-estrogenic anticancer agents in breast cancer.

Report

(4 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (20 results)

All 2006 2005 2004 Other

All Journal Article (19 results) Book (1 results)

  • [Journal Article] Down-regulation of Cap43/NDRGI/Drg-1, a Putative Differentiation-related and Metastasis Suppressor Gene, in Human Breast Cancer Cells.2006

    • Author(s)
      Fotovati A et al.
    • Journal Title

      Clin Cancer Res 12

      Pages: 3010-3018

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Activation of protein Kinase C δ induces growth arrest in NPA thyroid cancer cells through extracellular signal-regulated kinase mitogen-activated protein kinase.2006

    • Author(s)
      Koike K et al.
    • Journal Title

      Thyroid 16

      Pages: 333-341

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Characterization of IL-2-activated TILs and their use for Intrapericardial Immunotherapy in Malignant Pericardial Effusion.2006

    • Author(s)
      Toh U et al.
    • Journal Title

      Cancer Immunol Immun 55

      Pages: 1219-1227

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Characterization of IL-2-activated TILs and their use for Intrapericardial Immunotherapy in Malignant Pericardial Effusion.2006

    • Author(s)
      Toh U, Fujii T, Seki N, Niiya F, Shirouzu K, Yamana H.
    • Journal Title

      Cancer Immunol Immun 55

      Pages: 1219-1227

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Activation of protein Kinase C δ induces growth arrest in NPA thyroid cancer cells through extracellular signal-regulated kinase mitogen-activated protein kinase.2006

    • Author(s)
      Koike K, Fujii T, Nakamura AM, Yokoyama G, Yamana H, Kuwano M, Shirouzu K.
    • Journal Title

      Thyroid 16

      Pages: 333-341

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 17P-Estradiol Induces Down-regulation of Cap43/NDRG1/Drg-1, a Putative Differentiation-related and Metastasis Suppressor Gene, in Human Breast Cancer Cells.2006

    • Author(s)
      Fotovati A, Fujii T, Yamaguchi M, Kage M, Shirouzu K, Oie S, Basaki Y, Ono M, Yamana H, Kuwano M.
    • Journal Title

      Clin Cancer Res 12

      Pages: 3010-3018

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Characterization of IL-2-activated TILs and their use for Intrapericardial Immunotherapy in Malignant Pericardial Effusion.2006

    • Author(s)
      Toh U
    • Journal Title

      Cancer Immunol Immun 55

      Pages: 1219-1227

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 17β-Estradiol Induces Down-regulation of Cap43/NDRG1/Drg-1, a Putative Differentiation-related and Metastasis Suppressor Gene, in Human Breast Cancer Cells.2006

    • Author(s)
      Fotovati A
    • Journal Title

      Clin Cancer Res 12

      Pages: 3010-3018

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Activation of protein Kinase C 8 induces growth arrest in NPA thyroid cancer cells through extracellular signal-regulated kinase mitogen-activated protein kinase2006

    • Author(s)
      Koike K
    • Journal Title

      Thyroid 16

      Pages: 333-341

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Regulation of vascular smooth muscle proliferation and migration by β2-chimaerin, a non-protein kinase C phorbol ester receptor2006

    • Author(s)
      Maeda M
    • Journal Title

      Int J Mol Med 17

      Pages: 559-566

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Her2 overexpression increases sensitivity to gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, through inhibition of HER2/HER3 heterodimer formation in lung cancer cells.2005

    • Author(s)
      Hirata A et al.
    • Journal Title

      Cancer Res 65

      Pages: 4253-4260

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Her2 overexpression increases sensitivity to gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, through inhibition of HER2/HER3 heterodimer formation in lung cancer cells.2005

    • Author(s)
      Hirata A, Hosoi F, Miyagawa M, Ueda S, Naito S, Fujii T, Kuwano M, Ono M.
    • Journal Title

      Cancer Res 65

      Pages: 4253-4260

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The role of nuclear Y-box binding protein 1 as a global marker in drug resistance2005

    • Author(s)
      Kuwano M, Oda Y, Izumi H et al.
    • Journal Title

      Mol Cancer Ther 3

      Pages: 1485-1492

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Sensitivity to Gefitinib (Iressa, ZD1839) in non-small cell lung cancer cell lines correlates with dependence on the EGF receptor/ERK1/2 and EGF receptor/Akt pathway for proliferation.2004

    • Author(s)
      Ono M et al.
    • Journal Title

      Mol Cancer Ther 3

      Pages: 465-472

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The role of nuclear Y-box binding protein 1 as a global marker in drug resistance.2004

    • Author(s)
      Kuwano M et al.
    • Journal Title

      Mol Cancer Ther 3

      Pages: 1485-1492

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The role of nuclear Y-box binding protein 1 as a global marker in drug resistance.2004

    • Author(s)
      Kuwano M, Oda Y, Izumi H, Yang SJ, Uchiumi T, Iwamoto Y, Toi M, Fujii T, Yamana H, Kinoshita H, Kamura T, Tsuneyoshi M, Yasumoto K, Kohno K.
    • Journal Title

      Mol Cancer Ther 3

      Pages: 1485-1492

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Sensitivity to Gefitinib (Iressa, ZD1839) in non-small cell lung cancer cell lines correlates with dependence on the EGF receptor/ERK1/2 and EGF receptor/Akt pathway for proliferation.2004

    • Author(s)
      Ono M, Hirata A, Kometani T, Miyagawa M, Ueda S, Kinoshita H, Fujii T, Kuwano M.
    • Journal Title

      Mol Cancer Ther 3

      Pages: 465-472

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 17β-Estradiol Induces Down-regulation of Cap43/NDRG1/Drg-1, a Putative Differentiation-related and Metastasis Suppressor Gene, in Human Breast Cancer Cells.

    • Author(s)
      Fotovati A
    • Journal Title

      Clin Cancer Res (In press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Activation of protein Kinase C δ induces growth arrest in NPA thyroid cancer cells through extracellular signal-regulated kinase mitogen-activated protein kinase

    • Author(s)
      Koike K
    • Journal Title

      Thyroid (In press)

    • Related Report
      2005 Annual Research Report
  • [Book] The critical role of inflammatory cell infiltration in tumor angiogenesis a target for antitumor drug development?2005

    • Author(s)
      Kuwano M et al.
    • Publisher
      "New Angiogenesis Research", Nova Science Publishers, Inc., New York
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary

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Published: 2004-04-01   Modified: 2016-04-21  

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