• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Research of immunotherapy and splenectomy for chronic liver dysfunction.

Research Project

Project/Area Number 16591302
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionUniversity of Toyama (2005)
Toyama Medical and Pharmaceutical University (2004)

Principal Investigator

TSUKADA Kazuhiro  University of Toyama, Faculty of Medicine, Professor, 医学部, 教授 (90171967)

Co-Investigator(Kenkyū-buntansha) NAGATA Takuya  University of Toyama, Faculty of Hospital, Assistant professor, 附属病院, 講師 (40303242)
YAMAGISI Fuminori  University of Toyama, Faculty of Medicine, Associate professor, 医学部, 助教授 (50377248)
阿部 秀樹  富山医科薬科大学, 附属病院, 講師 (90345562)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2005: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2004: ¥2,100,000 (Direct Cost: ¥2,100,000)
KeywordsPortal hypertension / Splenomegaly / Activated T lymphocyte / 脾腫
Research Abstract

1.Making the animal experiment model of portal hypertension and splenomegaly.
We tried to make an animal experiment model that was going to reproduce a liver damage, portal hypertension and splenomegaly with a rat experimentally. We used a carbon tetrachloride treated group, a bacillus mort treated group, a bovine serum albumin (BSA) treated group, mitogen treated group, Portocaval shunt (PCS) group, a portal vein ligation county and tested it. It was confirmed that splenomegaly was developed in the group that were ligated the portal vein with two phases.
2.Clinical examination in portal hypertension cases
We adjusted lymphocyte from blood and spleen of portal hypertension patients that were performed splenectomy operation. And we analyzed the lymphocyte about expression of CD25,CD26,CD69,CD70 which was an activation marker by using the flowcyte meter. As a result, there were more activated T lymphocytes existed in preoperative blood of portal hypertension case, in comparison with control. In addition, a ratio of an early phase activated T lymphocyte was high in the extracted spleen. After operation, the ratio of the activated T lymphocyte of blood fell in transientness, but it increased again from three postoperative day. As a result, it was suggested, an early phase activated T lymphocyte was accumulated to the spleen in the portal hypertension patient, and after maturation, it flowed out into the peripheral blood.

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (31 results)

All 2005 2004

All Journal Article (27 results) Book (4 results)

  • [Journal Article] Metallic stent placement or gastroenterostomy for gastric outlet obstruction caused by gastric cancer?.2005

    • Author(s)
      Tsukada K.
    • Journal Title

      J Gastroenterol. 40

      Pages: 1007-1008

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 【特集】肝切除のコツを知るー出血を少なくするために肝切除におけるコツー出血を少なくするために2005

    • Author(s)
      塚田一博
    • Journal Title

      臨床外科 60(8)

      Pages: 993-997

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 胆嚢癌に対する拡大リンパ節郭清2005

    • Author(s)
      塚田一博
    • Journal Title

      手術 59(9)

      Pages: 1253-1257

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 局所進行胆嚢癌に対する標準的根治切除2005

    • Author(s)
      塚田一博
    • Journal Title

      消化器外科 28(10)

      Pages: 1493-1498

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Dieulafoy潰瘍様所見を呈した噴門部胃癌の1例.2005

    • Author(s)
      岸本浩史
    • Journal Title

      Gastroenterological Endoscopy 47(3)

      Pages: 313-317

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The selection of pancreatic reconstruction techniques gives rise to higher incidences of morbidity : results of the 30th Japan Pancreatic Surgery Questionnaire Survey on pancreatoduodenectomy in Japan.2005

    • Author(s)
      ABE H.
    • Journal Title

      J Hepatobiliary Pancreat Surg. 12

      Pages: 109-115

    • NAID

      10015710300

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Urinary Trypsin Inhibitor Suppresses Surgical Stress-facilitated Lung Metastasis of Murine Colon 26-L5 Carcinoma Cells.2005

    • Author(s)
      Yoshioka I.
    • Journal Title

      ANTICANCER RESEARCH 25

      Pages: 815-820

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cyclic AMP-dependent CI^- secretion induced by thromboxane A_2 isolated human colon.2005

    • Author(s)
      Horikawa N
    • Journal Title

      The physiological Society 562(3)

      Pages: 885-897

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Growth inhibition of human pancreatic cancer cells by human interferon-β gene combined with gemcitabine.2005

    • Author(s)
      Endo M.
    • Journal Title

      INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 15

      Pages: 277-283

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 腫瘍栓による膵管の拡張と急性胆管炎をきたした膵giant cell carcinoma(osteoclastoid type)の1例2005

    • Author(s)
      吉田徹
    • Journal Title

      消化器外科 28(8)

      Pages: 1311-1316

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] S状結腸狭窄を呈した群発型左側結腸憩室炎の1例.2005

    • Author(s)
      田澤賢一
    • Journal Title

      外科 67(6)

      Pages: 712-714

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Urinary Trypsin Inhibitor Suppresses Surgical Stress-facilitated Lung Metastasis of Murine Colon 26-L5 Carcinoma Cells.2005

    • Author(s)
      Yoshioka I. et al.
    • Journal Title

      ANTICANCER RESEARCH 25

      Pages: 815-820

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cyclic AMP-dependent CI^- secretion induced by thromboxane A_2 isolated human colon.2005

    • Author(s)
      Horikawa N. et al.
    • Journal Title

      The physiological Society 562(3)

      Pages: 885-897

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Growth inhibition of human pancreatic cancer cells by human interferon-β gene combined with gemcitabine.2005

    • Author(s)
      Endo M.et al.
    • Journal Title

      INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 15

      Pages: 277-283

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The selection of pancreatic reconstruction techniques gives rise to higher incidences of morbidity : results of the 30th Japan Pancreatic Surgery Questionnaire Survey on pancreatoduodenectomy in Japan.2005

    • Author(s)
      ABE H.et al.
    • Journal Title

      J Hepatobiliary Pancreat Surg 12

      Pages: 109-115

    • NAID

      10015710300

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 【術後合併症を防ぐ】術後合併症に関するインフォームド・コンセント2004

    • Author(s)
      塚田一博
    • Journal Title

      外科治療 90(4)

      Pages: 777-780

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Partial separating gastrojejunostomy for incurable cancer of the stomach or pancreas.2004

    • Author(s)
      Yamagishi F.
    • Journal Title

      Hepatogastroenterology 51(60)

      Pages: 1623-1625

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Is the CIC-2 chloride channel involved in the C1-secretory mechanism of gastric parietal cells?2004

    • Author(s)
      Honi K.
    • Journal Title

      FEBS Letters. 575

      Pages: 105-108

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Up-regulation of Na+,K+-ATPase α3-isoform and down-regulation of the α1-isoform in human colorectal cancer.2004

    • Author(s)
      Sakai H.
    • Journal Title

      FEBS Letters. 563

      Pages: 151-154

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 十二指腸乳頭腺腫の切除後再発に内視鏡的なAPCによる腫瘍燃灼術が奏効した1例2004

    • Author(s)
      渋谷和人
    • Journal Title

      Gastroenterological Endoscopy 59(9)

      Pages: 1253-1257

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 開胸経横隔膜的脾臓摘出術2004

    • Author(s)
      坂東 正
    • Journal Title

      手術 58(5)

      Pages: 709-713

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 経皮エタノール注入法(PEIT)、TS-1投与が奏効した胃癌術後肝転移の1例2004

    • Author(s)
      田澤賢一
    • Journal Title

      癌と化学療法 31(3)

      Pages: 403-405

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 大動脈周囲リンパ節および歯肉転移を切除した原発性肝癌の1例2004

    • Author(s)
      坂東 正
    • Journal Title

      日本臨床外科学会雑誌 65(8)

      Pages: 2178-2184

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 長期経過中に肝細胞癌と脾動脈瘤を合併したBudd-Chiari症候群の1治療例2004

    • Author(s)
      北見智恵
    • Journal Title

      日本消化器外科学会雑誌 37(11)

      Pages: 1743-1747

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Partial separating gastrojejunostomy for incurable cancer of the stomach or pancreas.2004

    • Author(s)
      Yamagishi F. et al.
    • Journal Title

      Hepatogastroenterology 51(60)

      Pages: 1623-1625

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Is the CIC-2 chloride channel involved in the C1-secretory mechanism of gastric parietal cells?2004

    • Author(s)
      Hori K.et al.
    • Journal Title

      FEBS Letters. 575

      Pages: 105-108

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Up-regulation of Na+,K+-ATPase α 3-isoform and down-regulation of theα 1-isoform in human colorectal cancer.2004

    • Author(s)
      Sakai H. et al.
    • Journal Title

      FEBS Letters. 563

      Pages: 151-154

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 外科疾患と栄養.「改訂版認定病態栄養専門師のための病態栄養ガイドブック」(日本病態栄養学会編)2005

    • Author(s)
      塚田一博
    • Publisher
      メディカルレビュー社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 一般的な術前処置.「前科術前術後のマニュアル」2005

    • Author(s)
      塚田一博
    • Publisher
      照林社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 門脈圧亢進症における門脈域分水嶺、消化器外科診療二頁の秘訣2004

    • Author(s)
      塚田一博
    • Publisher
      金原出版
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 膵臓癌のケアQ&A、術後ケアQ&A、消化器外科NURSING2004

    • Author(s)
      塚田一博
    • Publisher
      へるす出版
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary

URL: 

Published: 2004-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi