| Project/Area Number |
16591336
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | Nagoya City University |
|---|
Principal Investigator |
TAKEYAMA Hiromitsu Nagoya City University, Graduate School of Medical Sciences, Associate professor, 大学院・医学研究科, 助教授 (00216946)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MANABE Tadao Nagoya City University, Graduate School of Medical Sciences, Professor, 大学院・医学研究科, 教授 (80127141)
YAMAMOTO Minoru Nagoya City University, Graduate School of Medical Sciences, Research Associate, 大学院・医学研究科, 助手 (70347417)
OKADA Yuji Nagoya City University, Graduate School of Medical Sciences, Assistant professor, 大学院・医学研究科, 講師 (10305550)
WAKASUGI Takehiro Nagoya City University, Graduate School of Medical Sciences, Research Associate, 大学院・医学研究科, 助手 (30374151)
SAKAMOTO Masaki Nagoya City University, Graduate School of Medical Sciences, Research Associate, 大学院・医学研究科, 助手 (20381791)
|
|---|
| Project Period (FY) |
2004 – 2005
|
| Project Status |
Completed (Fiscal Year 2005)
|
| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2005: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2004: ¥1,800,000 (Direct Cost: ¥1,800,000)
|
|---|
| Keywords | AP-1 / MT-21 / Pancreatic cancer |
|---|
| Research Abstract |
We have studied for mechanism of signal transduction for metastasis and invasion of pancreatic cancer. We used four pancreatic cancer cell lines for our study.
We report the results that we acquired till now as fellows.
1.All four pancreatic cancer cell lines expressed c-jun mRNA and c-Jun protein.
2.Four pancreatic cancer cell lines had different activities of activator protein-1(AP-1). We suggest that there is a connection between activation of activator protein-1 and hepatic metastasis of pancreatic cancer.
3.MT-21 that activate AP-1 inhibited growth and invasive ability of pancreatic cancer cell lines in dose dependent.
4.We did not show the relationship between the metastatic and invasive activity, and the expression of AP-1 protein on surgical specimens.
In the future, we will try to make clear the relationship between pancreatic cancer and AP-1 furthermore.
|
