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Multidisciplinary Treatment against Colorectal Cancer Utilizing the Cell Cycle Checkpoint Regulation

Research Project

Project/Area Number 16591374
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionHyogo College of Medicine

Principal Investigator

YANAGI Hidenori  Hyogo College of Medicine, Faculty of Medicine, Associate Professor, 医学部, 助教授 (50241170)

Co-Investigator(Kenkyū-buntansha) YOSHIKAWA Reigetsu  Hyogo College of Medicine, Faculty of Medicine, Research Associate, 医学部, 助手 (90319864)
NODA Masafumi  Hyogo College of Medicine, Faculty of Medicine, Research Associate, 医学部, 助手 (30309463)
YAMAMURA Takehira  Hyogo College of Medicine, Faculty of Medicine, Professor, 医学部, 教授 (90068510)
HASHIMOTO Tomoko (TAMAOKI Tomoko)  Hyogo College of Medicine, Faculty of Medicine, Professor, 医学部, 教授 (10172868)
OKAMURA Haruki  Hyogo College of Medicine, Faculty of Medicine, Professor, 医学部, 教授 (60111043)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2005: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2004: ¥2,600,000 (Direct Cost: ¥2,600,000)
Keywordsdistant metastasis / colorectal cancer / polysaccharide-K(PSK) / integrated medicine / 化学療法 / 放射線療法 / 代替療法
Research Abstract

Distant metastasis is one of the major problems in treatment for advanced colorectal cancer. There is growing evidence that Polysaccharide-K (PSK), or Krestin (Sankyo Co., Tokyo, Japan), a mushroom ingredient, prevents distant metastases and improves survival rates by 10 to 20% in colorectal, gastric, esophageal, nasopharynx, lung, and breast cancers. We set out to investigate the possible role of PSK-related markers in predicting distant metastasis and the clinical outcome in colorectal cancer (CRC) patients. To screen PSK-related markers, we analyzed expression profiles using protein microarrays in a human colorectal adenocarcinoma cell line, SW480 with a mutant p53gene, and their clinical implication on the prognosis of CRC patients (n=35). We screened ECA39 protein, a direct target for c-Myc regulation, as a candidate relating to anti-metastatic effects of PSK. In immunohistochemistry, ECA39 was significantly expressed in the tumor tissues with distant metastases compared to the ones without metastases (p<0.00001). Positive ECA39 expression showed high reliability for the prediction of distant metastases (sensitivity : 86.7%, specificity : 90%, positive predictive value : 86.7%, and negative predictive value 90%). The cumulative 5-year disease free survival rate was 76% in the ECA39(-) group and 26% in the ECA39(+) group (p<0.05). Our results suggest that ECA39 is a dominant predictor of distant metastasis in patients with advanced CRC and may be useful for the application of immunotherapy by integrated medicine.

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (15 results)

All 2005 2004

All Journal Article (15 results)

  • [Journal Article] Polysaccharide-K (PSK) inhibits distant metastasis in colorectal cancer dependent on ECA39.2005

    • Author(s)
      Yoshikawa R et al.
    • Journal Title

      Proc Am Assoc Cancer Res 46・Suppl

      Pages: 171-171

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Clinical results of pharmacokinetic modulating chemotherapy (PMC) in combination with hepatic arterial 5FU infusion and oral UFT as adjuvant chemotherapy after liver resection for hepatic colorectal metastases.2005

    • Author(s)
      Noda M et al.
    • Journal Title

      Proc Am Soc Clin Oncol 23・16s

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A novel distant metastasis-related marker in colorectal cancer.2005

    • Author(s)
      Yoshikawa R et al.
    • Journal Title

      Proc Am Soc Clin Oncol 23・16s

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Polysaccharide-K (PSK) inhibits distant metastasis in colorectal cancer dependent on ECA39.2005

    • Author(s)
      Yoshikawa R, Yanagi H, Noda M, Yamamura T, Hashimoto-Tamaoki T.
    • Journal Title

      Proc AACR 46

      Pages: 171-171

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Clinical results of pharmacokinetic modulating chemotherapy (PMC) in combination with hepatic arterial 5FU infusion and oral UFT as adjuvant chemotherapy after liver resection for hepatic colorectal metastases.2005

    • Author(s)
      Noda M, Yanagi H, Yoshikawa R, Yamamura T, Kusunoki M.
    • Journal Title

      Proc ASCO 23

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A novel distant metastasis-related marker in colorectal cancer.2005

    • Author(s)
      Yoshikawa R, Hashimoto-Tamaoki T, Yanagi H, Noda M, Fujiwara Y, Gega M, Oshima T, Yamamura T.
    • Journal Title

      Proc ASCO 23

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Polysaccharide-K (PSK) inhibits distant metastasis in colorectal cancer dependent on ECA39.2005

    • Author(s)
      Yoshikawa R et al.
    • Journal Title

      Proc Am Assoc Cancer Res 46

      Pages: 171-171

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Clinical results of pharmacokinetic modulating chemotherapy (PMC) in combination with hepatic arterial 5FU infusion and oral UFT as adjuvant chemotherapy after liver resection for hepatic colorectal metastases.2005

    • Author(s)
      Noda M et al.
    • Journal Title

      Proc Am Soc Clin Oncol 23

    • Related Report
      2005 Annual Research Report
  • [Journal Article] A novel distant metastasis-related marker in colorectal cancer.2005

    • Author(s)
      Yoshikawa R et al.
    • Journal Title

      Proc Am Soc Clin Oncol 23

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Gene expression in response to anti-tumor intervention by polysaccaride-K (PSK) in colorectal carcinoma.2004

    • Author(s)
      Yoshikawa R et al.
    • Journal Title

      Oncol Rep 12・6

      Pages: 1287-1293

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 大腸癌に対する集学的治療2004

    • Author(s)
      柳 秀憲 他
    • Journal Title

      兵庫医科大学医学会雑誌 29・2

      Pages: 155-162

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Gene expression in response to anti-tumor intervention by polysaccharide-K (PSK) in colorectal carcinoma.2004

    • Author(s)
      Yoshikawa R, Yanagi H, Hashimoto-Tamaoki T, Morinaga T, Nakano Y, Noda M, Fujiwara Y, Okamura H, Yamamura T.
    • Journal Title

      Oncol Rep 12

      Pages: 1287-1293

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Second-look hepatectomy after pharmacokinetic modulating Chemotherapy (PMC) combination with hepatic arterial 5FU infusion and oral UFT in patients with unresectable hepatic colorectal metastases.2004

    • Author(s)
      Noda M, Yanagi H, Yoshikawa R, Yamamura T, Kusunoki, M.
    • Journal Title

      Proc ASCO 22

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Gene expression in response to anti-tumour intervention by polysaccharide-K (PSK) in colorectal carcinoma cells2004

    • Author(s)
      Yoshikawa R et al.
    • Journal Title

      Oncology Reports 12

      Pages: 1287-1293

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 大腸癌に対する集学的治療2004

    • Author(s)
      柳 秀憲 他
    • Journal Title

      兵医大医会誌 29・3

      Pages: 155-162

    • Related Report
      2004 Annual Research Report

URL: 

Published: 2004-04-01   Modified: 2016-04-21  

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