| Project/Area Number |
16591427
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Akita University |
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Principal Investigator |
MIZOI Kazuo Akita University, School of Medicine, Professor, 医学部, 教授 (70157519)
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| Co-Investigator(Kenkyū-buntansha) |
SASAJIMA Toshio Akita University, School of Medicine, Associate Professor, 医学部, 助教授 (40235289)
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2005: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2004: ¥2,400,000 (Direct Cost: ¥2,400,000)
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| Keywords | functional brain mapping / brain tumor / functional PET / functional MRI / magnetoencephalography / surgical navigation / fMRI |
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| Research Abstract |
The present study was carried out to establish the integration of functional brain mapping and positron emission tomography (PET) data into cranial navigation system to improve the treatment results of the patients with frontal brain tumors in close vicinity to Broca area. For eleven patients (ages 16-63 years) suffering from frontal brain tumors, functional mapping of speech area was examined with magnetoencephalogram (MEG), functional MRI (f-MRI) and functional PET (f-PET) while performing a verb generation task. Ten right-handed patients with left frontal brain tumors demonstrated left frontal activation which could be clearly located outside the tumor area and adjacent edema with varying degrees of additional right frontal activation. Remaining one left-handed patient with a right frontal brain tumor showed severe motor aphasia preoperatively, and it was difficult to detect speech-related brain areas in this patient. Functional mapping (MEG, f-MRI, f-PET) and metabolic (Met-PET) data were superimposed on the T1-weighted, contrast enhanced MRI scans with landmark correlation using VectorVision software (BrainLab Co, Germany). This multimodal image was used for surgical navigation of tumor resection with the VectorVision system. All four patients presenting with motor aphasia preoperatively showed the improvement on the symptom after surgery. Six of the 7 patients without preexisting speech disturbance were symptom-free on the postoperative course. Remaining one patient showed transient motor aphasia postoperatively, and the symptom disappeared in about 10 days. Functional mapping was also undertaken postoperatively, and it was demonstrated that speech areas were preserved in all cases. The present study is indicating that multimodal neuronavigation allows safer and more complete surgery with less morbidity for the patients with frontal brain tumors close to language areas.
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