| Project/Area Number |
16591442
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | The University of Tokushima |
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Principal Investigator |
SATOH Koichi The University of Tokushima, Institute of Health Biosciences, Associate Professor, 大学院・ヘルスバイオサイエンス研究部, 助教授 (90225938)
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| Co-Investigator(Kenkyū-buntansha) |
UNO Masaaki The University of Tokushima, Institute of Health Biosciences, Assistant Professor, 大学院・ヘルスバイオサイエンス研究部, 講師 (90232884)
NAGAHIRO Shinji The University of Tokushima, Institute of Health Biosciences, Professor, 大学院・ヘルスバイオサイエンス研究部, 教授 (60145315)
MATSUBARA Shunji The University of Tokushima, University Medical and Dental Hospital, Assistant Professor, 医学部・歯学部附属病院, 講師 (60294675)
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2005: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2004: ¥2,300,000 (Direct Cost: ¥2,300,000)
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| Keywords | cerebral aneurysm / electron microscopy / estradiol hormone / replacement therapy / rat model / vascular cast |
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| Research Abstract |
1.To identify early ultrastructural morphological changes that lead to the formation of experimental cerebral aneurysm (CA), we induced renal hypertension and right common carotid artery ligation. A vascular corrosion cast of their cerebral arteries was prepared. Our morphological findings point to the principal role of endothelial cells in the pathogenesis of CA by hemodynamic shear stress (J Neurosurg. 2005,;102,:532-5). In addition, to clarify the series of early events that leads to IA formation, the aneurysmal morphological changes on vascular corrosion cast to its parallel pathological changes in cerebral arteries were compared. We proposed that the formation of IAs starts with endothelial injury at the apical intimal pad (stage I), this lead to the formation of inflammatory zone (stage II). Partial tear or defect in the inflammatory zone will follow. Expansion of this defect forms the nidus for IA (stage III).
2.To further elucidate the role of hormones, we examined the effects of oophorectomy. The oophorectomy increased the susceptibility of rats to aneurysm formation, indicating that hormones play a role in the pathogenesis of cerebral aneurysms. (J Neurosurg. 2005;103:1046-51)
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