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Clinical relevance of CD-RAP in disease of orthopaedics

Research Project

Project/Area Number 16591483
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionNagoya University

Principal Investigator

NISHIDA Yoshihiro  Nagoya University, University Hospital, Assistant Professor, 医学部附属病院, 講師 (50332698)

Co-Investigator(Kenkyū-buntansha) MISHIMA Shinji  Nagoya University, University Hospital, Medical Staff, 医学部附属病院, 医員 (60378114)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2005: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2004: ¥2,800,000 (Direct Cost: ¥2,800,000)
KeywordsCD-RAP / bone and soft tissue tumor / tumor marker / osteoarthritis / arthritis marker / 予後予測因子 / 関節リウマチ
Research Abstract

It was demonstrated that serum levels of CD-RAP is significantly higher in patients of osteoarthritis compared to rheumatoid arthritis. Interestingly, as stage of the disease progressed, the levels of CD-RAP was decreased in osteoarthritic patients. It suggests that serum levels of CD-RAP could be markers of disease progression in addition to roentgenogram and physical examination.
Serum levels of CD-RAP was also determined in patients of bone and soft tissue sarcoma with ELISA analysis. Significant higher serum levels of CD-RAP were detected in osteosarcoma and chordoma patients compared to normal volunteer. Protein and mRNA expression were also determined with immunohistochemistry and RT-PCR. In consistent with ELISA results, protein and mRNA expression were confirmed in samples of osteosarcoma and chordoma. Serum levels of CD-RAP were subjected to the analysis for correlation to prognosis of malignant tumors patients. Due to the relatively small number of cases, there was no significant correlation between serum levels of CD-RAP and the prognosis of the patients, but there was significant correlation to the size of the tumors. Given that significant prognostic factors are important for osteosarcoma patients, we analyzed other molecules to be correlated with the prognosis. It was demonstrated that increased expression of membrane-type matrix metalloproteinase-1 was correlated with poor prognosis in patients with osteosarcoma. It could be promising marker for prognosis of osteosarcoma patients. Evaluation of membrane-type matrix metalloproteinase-1 expression in biopsy samples might indicate poor prognosis patients, and we could pick up these patients, and subject to the intensive therapy.

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (24 results)

All 2005 2004

All Journal Article (24 results)

  • [Journal Article] Regenerationg the fibula with beta-tricalcium phosphate minimizes morbidity ofter fibula resection.2005

    • Author(s)
      Arai E
    • Journal Title

      Clim Orthop Rel Res 431

      Pages: 233-237

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Hyaluronan oligosaccharides inhibit proliferation and invasiveness of osteosarcoma cell line, MG-63, by suppression oh hyaluronan in pericelluar matrix of the tumor cells.2005

    • Author(s)
      Hosono K
    • Journal Title

      Trans Orthop Res Soc 30

      Pages: 435-435

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Dose-dependent inhibition of proliferation, invasiveness and stimulation of apoptosis in osteosarcoma cell line, MG-63, by COX-2 inhibitor, meloxicam.2005

    • Author(s)
      Naruse T
    • Journal Title

      Trans Orthop Res Soc 30

      Pages: 436-436

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Antisense inhibition of hyaluronan synthase-2 in human osteosarcoma cells inhibits hyaluronan retention and tumorigenicity.2005

    • Author(s)
      Nishida Y
    • Journal Title

      Exp Cell Res 307

      Pages: 194-203

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Sentinel lymph node biopsy reveals a positive popliteal node in clear cell sarcoma : a case report.2005

    • Author(s)
      Nishida Y
    • Journal Title

      Anticancer Res 25(6C)

      Pages: 4413-6

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Increased expression of membrane-type martix metalloproteinase-1 is correlated with poor prognosis in patients with osteosarcoma.2005

    • Author(s)
      Uchibori M
    • Journal Title

      Int J Oncol 28(1)

      Pages: 33-42

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] HRegeneating the fibula with beta-tricalcium phosphate minimizes morbidity after fibula resection.2005

    • Author(s)
      Arai, E.
    • Journal Title

      Clin Orthop Rel Res 431

      Pages: 233-237

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Hyaluronan oligosaccharides inhibit proloferation and invasiveness of osteosarcoma cell line, MG-63, by suppression of hyaluronan in pericellular matrix of the tumor cells.2005

    • Author(s)
      Hosono, K.
    • Journal Title

      Trans Orthop Res Soc 30

      Pages: 435-435

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Dose-dependent inhibition of proliferaion, invasiveness and stimulation of apoptosis in osteosarcoma cell line, MG-63, by COX-2 inhibitor, meloxicam.2005

    • Author(s)
      Naruse, T.
    • Journal Title

      Trans Orthop Res Soc 30

      Pages: 436-436

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Antisense inhibition of hyaluronan synthase-2 in human osteosarcoma cells inhibits hyaluronan retention and tumorigenicity.2005

    • Author(s)
      Nishida, Y.
    • Journal Title

      Exp Cell Res 307

      Pages: 194-203

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Sentinel lymph node biospy reveals a positive popliteal node in clear cell sarcoma: a case report.2005

    • Author(s)
      Nishida, Y.
    • Journal Title

      Anticancer Res 25(6C)

      Pages: 4413-4416

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Increased expression of membrane-type matrix metalloproteinase-1 is correlated with poor prognosis in patients with osteosarcoma.2005

    • Author(s)
      Uchibori, M.
    • Journal Title

      Int J Oncol 28(1)

      Pages: 33-42

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Regenerating the fibula with beta-tricalcium phosphate minimizes morbidity after fibula resection.2005

    • Author(s)
      Arai E
    • Journal Title

      Clin Orthop Rel Res 431

      Pages: 233-237

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Hyaluronan oligosaccharides inhibit proliferation and invasiveness of osteosarcoma cell line, MG-63, by suppression of hyaluronan in pericellular matrix of the tumor cells.2005

    • Author(s)
      Hosono K
    • Journal Title

      Trans Orthop Res Soc 30

      Pages: 435-435

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Increased expression of membrane-type matrix metalloproteinase-1 is correlated with poor prognosis in patients with osteosarcoma.2005

    • Author(s)
      Uchibori M
    • Journal Title

      Int.J Oncol. 28(1)

      Pages: 33-42

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Regenerating the fibula with beta-tricalcium phosphate minimizes morbidity after fibula resection.2005

    • Author(s)
      Arai E, Nakashima H, Tsukushi S, Shido Y, Nishida Y, Yamada Y, Sugiura H, Katagiri H.
    • Journal Title

      Clin Orthop Rel Res 431

      Pages: 233-237

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Expression of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Pigmented Villonodular Synovitst Suggests Their Potential Role for Joint Destruction.2004

    • Author(s)
      Uchidori M
    • Journal Title

      J Rheum 31

      Pages: 110-119

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Osteogenic Protein-1 inhibits matrix depletion in a hyaluronan hexasaccharide-induced model of osteoarthritis.2004

    • Author(s)
      Nishida Y
    • Journal Title

      Osteoarthritis Cartilage 12

      Pages: 374-82

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Inhibition of hyaluronan synthesis in osteosarcoma cell line, MG-63, reduces the tumorigenicity of the cells.2004

    • Author(s)
      Nishida Y
    • Journal Title

      Trans Orthop Res Soc 29

      Pages: 963-963

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Expression of Matrix Metalloproteinases and Tissue Inhibitors of Metalloprotenases in Pigmented Villonodular Synovitis Suggests Their Potential Role of Joint Destruction.2004

    • Author(s)
      Uchibori, M.
    • Journal Title

      J Rheum 31

      Pages: 110-119

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Osteogenic Protein-1 inhibits matrix depletion in a hyaluronan hexasaccharide-induced model of osteoarthritis.2004

    • Author(s)
      Nishida, Y.
    • Journal Title

      Osteoarthritis Cartilage 12

      Pages: 374-382

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Inhibition of hyaluronan synthesis in osteosarcoma cell line, MG-63, reduces the tumorigenicity of the cells.2004

    • Author(s)
      Nishida, Y.
    • Journal Title

      Trans Orthop Res Soc 29

      Pages: 963-963

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Expression of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Pigmented Villonodular Synovitis Suggests Their Potential Role for Joint Destruction.2004

    • Author(s)
      Mitsutoshi Uchibori, Yoshihiro Nishida, Izuru Tabata, Hideshi Sugiura, Hiroatsu Nakashima, Yoshihisa Yamada, Naoki ishiguro
    • Journal Title

      J Rheum 31

      Pages: 110-119

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Osteogenic Protein-I inhibits matrix depletion in a hyaluronan hexasaccharide-induced model of osteoarthritis.2004

    • Author(s)
      Yoshihiro Nishida, Cheryl B Knudson, Warren Knudson.
    • Journal Title

      Osteoarthritis Cartilage 12

      Pages: 374-382

    • Related Report
      2004 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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