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Osteochondral regeneration using autologous cell construct with β TCP

Research Project

Project/Area Number 16591497
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionKyushu University

Principal Investigator

MATSUDA Shuichi  Kyushu University, Department of Orthopaedic Surgery, Assistant Professor (40294938)

Project Period (FY) 2004 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,710,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2006: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2005: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2004: ¥1,100,000 (Direct Cost: ¥1,100,000)
Keywordscartilage repair / mesenchymal stem cell / TCP / type II collagen / chondrocyte
Research Abstract

We established a new method to make cell only construct on TCP to repair osteochondral defect.
Mesenchymal stem cells (MSCs) were obtained from the iliac crest of Japanese-white-rabbit. Monolayer expanded cells were mold into a cylinder of 4.8mm in diameter and 4mm in height on TCP. The autologous labeled-MSC plug was implanted with TCP in the patellofemoral groove of the rabbit. The knees were immobilized for one week. The rabbits were sacrificed at 3, 6, 12, 24, and 52 weeks after operation. The specimens were evaluated histologically and scanned with micro CT.
In gross appearance of the cartilage at 6 weeks, most of the surface of the defect was covered with cartilage-like tissue. Smooth surfaces were maintained in regenerated cartilage at one year. Histologically, columnar distribution of the chondrocyte was observed in regenerated hyaline cartilage. In the subchondral bone level, endochondral ossification occurred at the peripheral area of the transplants, and small area in the central remained hyaline cartilage. Micro CT showed further ossification in subchondral bone level. Confocal microscopy detected the labeled cells both in cartilage layer and subchondral bone layer.
The current study suggests that this cell-delivery system can be used for treatment of osteochondral defect and possibly for osteoarthritis.

Report

(5 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (71 results)

All 2007 2006 2005 2004

All Journal Article (44 results) (of which Peer Reviewed: 21 results) Presentation (25 results) Book (2 results)

  • [Journal Article] Femoral shaft bowing influences the correction angle for high tibial osteotomy2007

    • Author(s)
      Nagamine R, Inoue S, Miura H, Matsuda S, et. al.
    • Journal Title

      J Orthop Sci 12

      Pages: 214-218

    • NAID

      10020157897

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Assessment of Anterolateral Rotatory Instability in the Anterior Cruciate Ligament-Deficient Knee Using an Open Magnetic Resonance Imaging System2007

    • Author(s)
      Okazaki K, Miura H, Matsuda S, et. al.
    • Journal Title

      Am J Sports Med 35

      Pages: 1091-1097

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Minimally invasive versus standard approach in total knee arthroplasty2007

    • Author(s)
      Tashiro Y, Miura H, Matsuda S, et. al.
    • Journal Title

      Clin Orthop 463

      Pages: 144-150

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 骨髄間葉系幹細胞を用いた骨軟骨複合組織の作成、および軟骨欠損の治療への応用2007

    • Author(s)
      松田秀一, 他
    • Journal Title

      日本整形外科スポーツ医学会雑誌 27

      Pages: 215-221

    • NAID

      10025706009

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Femoral shaft bowing influences the correction angle for high tibial osteotomy2007

    • Author(s)
      Nagamine, R., Inoue, S., Miura, H., Matsuda, S., Iwamoto, Y
    • Journal Title

      J Orthop Sci 12(3)

      Pages: 214-8

    • NAID

      10020157897

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Assessment of Anterolateral Rotatory Instability in the Anterior Cruciate Ligament-Deficient Knee Using an Open Magnetic Resonance Imaging System2007

    • Author(s)
      Okazaki, K., Miura, H., Matsuda, S., Yasunaga, T., Nakashima, H., Konishi, K., Iwamoto, Y., Hashizume, M
    • Journal Title

      Am J Sports Med 35(7)

      Pages: 1091-7

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Minimally invasive versus standard approach in total knee arthroplasty2007

    • Author(s)
      Tashiro, Y., Miura, H., Matsuda, S., Okazaki, K., Iwamoto, Y
    • Journal Title

      Clin Orthop 463

      Pages: 144-150

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 骨髄間葉系幹細胞を用いた骨軟骨複倉組織の作成、および軟骨欠損の治療への応用2007

    • Author(s)
      松田 秀一, 他
    • Journal Title

      日本整形外科スポーツ医学会雑誌 27

      Pages: 215-221

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ナノクリスタルでラベリングした間葉系幹細胞の骨軟骨欠損部移植後の検出2006

    • Author(s)
      中山 功一、松田 秀一, 他
    • Journal Title

      日本整形外科学会雑誌 80

      Pages: 1104-1104

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] -TCPと間葉系幹細胞を用いた広範囲関節軟骨再生の試み2006

    • Author(s)
      中山 功一、松田 秀一, 他
    • Journal Title

      日本整形外科学会雑誌 80

      Pages: 981-981

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] HMG-CoA還元酵素阻害剤(スタチン)は骨髄間葉系細胞の軟骨特異的遺伝子発現を促進する2006

    • Author(s)
      赤崎 幸穂、松田 秀一, 他
    • Journal Title

      日本整形外科学会雑誌 80

      Pages: 1106-1106

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Asymmetry of mediolateral laxity of the normal knee2006

    • Author(s)
      Okazaki K, Miura H, Matsuda S, et. al.
    • Journal Title

      J Orthop Sci 11

      Pages: 264-266

    • NAID

      10018362254

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Anteroposterior stability in posterior cruciate ligament-retaining total knee arthroplasty2006

    • Author(s)
      Mizu-uchi H, Matsuda S, et. al.
    • Journal Title

      J Arthroplasty 21

      Pages: 592-598

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] The extramedullary guide of the proximal tibia resection should be seen in front during total knee arthroplasty2006

    • Author(s)
      Nagamine R, Matsunobu T, Takayama M, Miura H, Matsuda S, et. al.
    • Journal Title

      Fukuoka Acta Medica 97

      Pages: 146-151

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Arthroscopic Resection of the Discoid Lateral Meniscus:Long-term Follow-up for16 Years2006

    • Author(s)
      Okazaki K, Miura H, Matsuda S, et. al.
    • Journal Title

      Arthroscopy 97

      Pages: 967-971

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Functional evaluation of four patients treated with V-Y quadricepsplasty in total knee arthroplasty2006

    • Author(s)
      Tsukamoto N, Miura H, Matsuda S, et. al.
    • Journal Title

      J Orthop Sci 11

      Pages: 94-400

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] The Effect of Ankle Rotation on Cutting Error of the Tibia in Total Knee Arthroplasty2006

    • Author(s)
      Mizu-uchi H, Matsuda S, et. al.
    • Journal Title

      Journal of Bone and Joint Surg Am 88

      Pages: 2632-2636

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Asymmetry of mediolateral laxity of the normal knee2006

    • Author(s)
      Okazaki, K., Miura, H., Matsuda, S., Takeuchi, N., Mawatari, T., Hashizume, M., Iwamoto, Y
    • Journal Title

      J Orthop Sci 11(3)

      Pages: 264-266

    • NAID

      10018362254

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Anteroposterior stability in posterior cruciate ligament-retaining total knee arthroplasty2006

    • Author(s)
      Mizu-uchi, H., Matsuda, S., Miura, H., Nabeyama, R., Okazaki, K., Iwamoto, Y
    • Journal Title

      J Arthroplasty 21

      Pages: 592-598

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The extramedullary guide of the proximal tibia resection should be seen in front during total knee arthroplasty2006

    • Author(s)
      Nagamine, R., Matsunobu, T., Takayama, M., Miura, H., Matsuda, S., Iwamoto, Y
    • Journal Title

      Fukuoka Acta Medica 97

      Pages: 146-151

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] rthroscopic Resection of the Discoid Lateral Meniscus : Long-term Follow-up for 16 Years2006

    • Author(s)
      Okazaki, K., Miura, H., Matsuda, S., Hashizume, M., Iwamoto, Y
    • Journal Title

      Arthroscopy 22(9)

      Pages: 967-971

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Functional evaluation of four patients treated with V-Y quadricepsplasty in total knee arthroplasty2006

    • Author(s)
      Tsukamoto, N., Miura, H., Matsuda, S., Mawatari, T., Kato, H., Iwamoto, Y
    • Journal Title

      J Orthop Sci. 11(4)

      Pages: 394-400

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The Effect of Ankle Rotation on Cutting Error of the Tibia in Total Knee Arthroplasty2006

    • Author(s)
      Mizu-uchi, H., Matsuda, S., Miura, H., Higaki, H., Okazaki, K., Iwamoto, Y
    • Journal Title

      J Bone and Joint Surg Am 88

      Pages: 2632-6

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] ナノクリスタルでラベリングした間葉系肝細胞の軟骨欠損部移植後の検出2006

    • Author(s)
      中山功一, 松田秀一, 田仲和宏, 三浦裕正, 赤崎幸穂, 岩本幸英
    • Journal Title

      日本整形外科学会雑誌 80・8

      Pages: 1104-1104

    • Related Report
      2006 Annual Research Report
  • [Journal Article] α-TCPと間葉系肝細胞を用いた広範囲関節軟骨再生の試み2006

    • Author(s)
      中山功一, 松田秀一, 赤崎幸穂, 三浦裕正, 岩本幸英
    • Journal Title

      日本整形外科学会雑誌 80・8

      Pages: 981-981

    • Related Report
      2006 Annual Research Report
  • [Journal Article] HMG-CoA還元酵素阻害剤(スタチン)は骨髄間葉系細胞の軟骨特異的遺伝子発現を促進する2006

    • Author(s)
      赤崎幸穂, 松田秀一, 中山功一, 水内秀城, 深川真吾, 岩元幸英
    • Journal Title

      日本整形外科学会雑誌 80・8

      Pages: 1201-1201

    • Related Report
      2006 Annual Research Report
  • [Journal Article] HMG-CoA還元酵素阻害剤(スタチン)は骨髄間葉系細胞の軟骨分化を促進する2006

    • Author(s)
      赤崎幸穂, 松田秀一, 中山功一, 田仲和宏, 三浦裕正, 岩本幸英
    • Journal Title

      移植 41・5

      Pages: 514-514

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Scaflbldを用いない未分化間葉系幹細胞デリバリーシステムを用いた骨軟骨の再生2005

    • Author(s)
      中山 功一、松田 秀一, 他
    • Journal Title

      日本整形外科学会雑誌 79

      Pages: 809-809

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Importance of the lateral anatomic tibial slope as a guide to the tibial cut in total knee arthroplasty in Japanese patients2005

    • Author(s)
      Kuwano T, Urabe K, Miura H, Nagamine R, Matsuda S, et. al.
    • Journal Title

      J Orthop Sci. 10

      Pages: 42-47

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Contact stress at the post-cam mechanism in posterior stabilized total knee arthro plasty2005

    • Author(s)
      Nakayama K, Matsuda S, et. al.
    • Journal Title

      J Bone Joint Surg Br 87

      Pages: 483-488

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Validity of an oblique posterior condylar radiographic view for revision total knee arthroplasty2005

    • Author(s)
      Miura H, Matsuda S, et. al.
    • Journal Title

      J Bone Joint Surg Br 87

      Pages: 1643-1646

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Importance of the lateral anatomic tibial slope as a guide to the tibial cut in total knee arthroplasty in Japanese patients2005

    • Author(s)
      Kuwano, T., Urabe, K., Miura, H., Nagamine, R., Matsuda, S., Satomura, M., Sasaki, T., Sakai, S., Honda, H., wamoto, Y
    • Journal Title

      J Orthop Sci. 10(1)

      Pages: 42-7

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Contact stress at the post-cam mechanism in posterior stabilized total knee arthroplasty2005

    • Author(s)
      Nakayama, K., Matsuda, S., Miura, H., Higaki, H., Otsuka, K., Iwamoto, Y
    • Journal Title

      J Bone Joint Surg Br 87(12)

      Pages: 1643-6

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Validity of an oblique posterior condylar radiographic view for revision total knee arthroplasty2005

    • Author(s)
      Miura, H., Matsuda, S., Okazaki, K., Kawano, T., Kawamura, Iwamoto, Y
    • Journal Title

      J Bone Joint Surg Br 87(12)

      Pages: 1643-6

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Tracking implanted mesenchymal stem cells in vivo with nano-crystal reagents2005

    • Author(s)
      Nakayama K, Matsuda S, Y Akasaki, K Tanaka, H Miura, Y Iwamoto
    • Journal Title

      Transaction of The 4th Annual Meeting of the European Tissue Engineering Society

      Pages: 19-19

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Novel cell delivery system without carrier vehicle : Regeneration of rabbit ostes-chondral defect with autologous mesenchymal stem cell2005

    • Author(s)
      Nakayama K, Matsuda S, Y Akasaki, K Tanaka, H Miura, Y Iwamoto
    • Journal Title

      Transactioin of The 8^<th> Annual Meeting of Tissue engineering Society International

      Pages: 152-152

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Anatomical Analysis of the Femoral Condyle in Normal and Osteoarthritic Knees2004

    • Author(s)
      Matsuda S, et. al.
    • Journal Title

      J Orthop Res 22

      Pages: 104-109

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] The oblique posterior condylar radiographic view to evaluate the posterior femoral condyle following total knee arthroplasty2004

    • Author(s)
      Miura H, Matsuda S, et. al.
    • Journal Title

      J Bone Joint Surg Am 86

      Pages: 47-50

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] The Accuracy of computed tomography-based image-guided total knee arthroplasty2004

    • Author(s)
      Nabeyama R, Matsuda S, et. al.
    • Journal Title

      Bone Joint Surg Br 86

      Pages: 366-371

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Anatomical Analysis of the Femoral Condyle in Normal and Osteoarthritic Knees2004

    • Author(s)
      Matsuda, S., Miura, H., Nagamine, R., Mawatari, T., Tokunaga, M., Nabeyama, R., Iwamoto, Y
    • Journal Title

      J Orthop Res 22

      Pages: 104-109

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The oblique posterior condylar radiographic view to evaluate the posterior femoral condyle following total knee arthroplasty2004

    • Author(s)
      Miura, H., Matsuda, S., Mawatari, T., Kawano, T., Nabeyama, R., Iwamoto, Y
    • Journal Title

      J Bone Joint Surg Am 86

      Pages: 47-50

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The Accuracy of computed tomography-based image-guided total knee arthroplasty2004

    • Author(s)
      Nabeyama, R., Matsuda, S., Miura, H., Mawatari, T., Kawano, T., Iwamoto, Y
    • Journal Title

      J Bone Joint Surg Br 86

      Pages: 366-371

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] In Vivo Study of Scaffold Free Mesenchymal Stem Cell Plug for Cartilage Repair2004

    • Author(s)
      Nakayama K, Matsuda S, Tanaka K, Mizuchi H, Iwamoto Y
    • Journal Title

      Transaction of the 5th bi-annual meeting of International Cartilage Repair Society

      Pages: 94-94

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Scaffold Free Mesenchymal Stem Cell Plug for Autologous Repair of Osteo-Chondral Defect in Rabbit2004

    • Author(s)
      Nakayama K, Matsuda S, Tanaka K, Iwamoto Y
    • Journal Title

      Transaction of 5th Combined Meeting of the Orthopaedic Research Societies of Canada, U.S.A., Japan and Europe

      Pages: 220-220

    • Related Report
      2004 Annual Research Report
  • [Presentation] HMG-CoA還元酵素阻害剤(スタチン)は骨髄間葉系細胞の軟骨分化を誘導する2007

    • Author(s)
      赤崎 幸穂, 松田 秀一, 他
    • Organizer
      第20回 日本軟骨代謝学会
    • Place of Presentation
      岡山
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Scaffold free MSCデリバリーシステムを用いた骨軟骨再生の一年成績2007

    • Author(s)
      中山 功一、松田 秀一, 他
    • Organizer
      第20回日本軟骨代謝学会
    • Place of Presentation
      岡山
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] HMG-CoA還元酵素阻害剤(スタチン)は骨髄間葉系細胞の軟骨分化を誘導する2007

    • Author(s)
      赤崎 幸穂, 松田 秀一, 他
    • Organizer
      第39回日本結合組織学会学術大会・第54回マトリックス研究会大会合同学術集会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Statin induces chondrogenic differentiation in bone marrow stromal cells2007

    • Author(s)
      Akasaki Y, Matsuda S, et. al.
    • Organizer
      The 53rd Annual Meeting of Orthopaedic ResearchSociety
    • Place of Presentation
      San Diego,USA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Overview of cartilage tissue engineering2007

    • Author(s)
      Nakayama K, Matsuda S, et. al.
    • Organizer
      15th Triennial Congress of Asia Pacific Orthopaedic Association
    • Place of Presentation
      Scoul,Korea
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] One-year follow up of osteo-chondral regeneration in rabbit by scaffold free mesenchymal stem cell implantation2007

    • Author(s)
      Nakayama K, Matsuda S, et. al.
    • Organizer
      One-year follow up of osteo-chondral regeneration in rabbit by scaffold free mesenchymal stem cell implantation
    • Place of Presentation
      Warsaw,Poland
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Statin induces chondrogenic differentiation in bone marrow stromal cells2007

    • Author(s)
      Akasaki, Y., Matsuda, S., Nakayama, K., Mizu-uchi, H., Fukagawa, S., Iwamoto, Y
    • Organizer
      The 53rd Annual Meeting of Orthopaedic Research Society
    • Place of Presentation
      San Diego, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] One-year follow up of osteo-chondral regeneration in rabbit by scaffold free mesenchymal stem cell implantation2007

    • Author(s)
      Nakayama, K., Matsuda, S., Akasaki, Y., Fukagawa, S., Iwamoto, Y
    • Organizer
      7th World Congress of International Cartilage Repair Society
    • Place of Presentation
      Warsaw, Poland
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Overview of cartilage tissue engnieering2007

    • Author(s)
      Nakayama K, Matsuda S, et. al.
    • Organizer
      15^<th> Triennial Congress of Asia Pacific Orthopaedic Association
    • Place of Presentation
      Seoul,Korea
    • Related Report
      2007 Annual Research Report
  • [Presentation] One-year follow up of osteo-chondral regeneration in rabbit by scaffold free mesenchymal stem cell implantation2007

    • Author(s)
      Nakayama K, Matsuda S, et. al.
    • Organizer
      7^<th> World Congress of International Cartilage Repair Society
    • Place of Presentation
      Warsaw,Poland
    • Related Report
      2007 Annual Research Report
  • [Presentation] HMG-CoA還元酵素阻害剤(スタチン)は骨髄間葉系細胞の軟骨分化を促進する2006

    • Author(s)
      赤崎 幸穂, 松田 秀一, 他
    • Organizer
      第25回 日本運動器移植・再生医学研究会
    • Place of Presentation
      東京
    • Year and Date
      2006-09-23
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Scaffbldを用いない未分化間葉系幹細胞デリバリーシステム用いた骨軟骨の再生2005

    • Author(s)
      中山 功一、松田 秀一、他
    • Organizer
      第20回日本整形外科学会基礎学術集会
    • Place of Presentation
      伊勢
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Tracking implanted mesenchymal stem cells in vivo with nano-crystalreagents2005

    • Author(s)
      Nakayama K, Matsuda S, et. al.
    • Organizer
      The 4th Annual Meeting of the Europearn Tissue Engineering Society
    • Place of Presentation
      Munich,Germany
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] -TCPと間葉系幹細胞を用いた広範囲関節軟骨再生の試み2005

    • Author(s)
      中山 功一、松田 秀一, 他
    • Organizer
      第21回日本整形外科学会基礎学術集会
    • Place of Presentation
      長崎
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ナノクリスタルでラベリングした間葉系幹細胞の骨軟骨欠損部移植後の検出2005

    • Author(s)
      中山 功一、松田 秀一, 他
    • Organizer
      第21回日本整形外科学会基礎学術集会
    • Place of Presentation
      長崎
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] HMG-CoA還元酵素阻害剤(スタチン)は骨髄間葉系細胞の軟骨分化を誘導する2005

    • Author(s)
      赤崎 幸穂, 松田 秀一, 他
    • Organizer
      第21回日本整形外科学会基礎学術集会
    • Place of Presentation
      長崎
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Tracking implanted mesenchymal stem cells in vivo with nano-cry stalreagents2005

    • Author(s)
      Nakayama, K., Matsuda, S., Akasaki, Y., Tanaka, K., Miura, H., Iwamoto, Y
    • Organizer
      The 4th Annual Meeting of the Europearn Tissue Engineering Society
    • Place of Presentation
      Munich, Germany
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 細胞単独からなる自家骨髄間葉系幹細胞プラグを用いた軟骨再生2004

    • Author(s)
      中山 功一、松田 秀一, 他
    • Organizer
      第23回日本運動器移植・再生医学研究会
    • Place of Presentation
      岡山
    • Year and Date
      2004-09-18
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 細胞単独からなる間葉系幹細胞プラグを用いた軟骨の再生2004

    • Author(s)
      中山 功一、松田 秀一, 他
    • Organizer
      第1回 福岡再生医療研究会
    • Place of Presentation
      福岡
    • Year and Date
      2004-05-31
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 細胞単独からなる骨軟骨様プラグの作成2004

    • Author(s)
      中山 功一、松田 秀一, 他
    • Organizer
      第17回日本軟骨代謝学会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 細胞単独からなる間葉系幹細胞プラグを用いた軟骨の再生2004

    • Author(s)
      中山 功一、松田 秀一, 他
    • Organizer
      第36回日本結合組織学会学術大会
    • Place of Presentation
      福岡
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] In vivo study of scaffold free mesenchymal stem cell plug for cartilage repair2004

    • Author(s)
      Nakayama K, Matsuda S, et. al.
    • Organizer
      The 5th bi-annual meeting of lnternational Cartilage Repair Society
    • Place of Presentation
      Gent,Belgium
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Scaffold free mesenchymal stem cell plug for autolgous repair of osteochondral defect in rabbit2004

    • Author(s)
      Nakayama K, Matsuda S, et. al.
    • Organizer
      5th Combined Meeting of the Orthopaedic Research Societies of Canada, U.S.A., Japan and Europe
    • Place of Presentation
      Alberta,Canada
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] In vivo study of scaffold free mesenchymal stem cell plug for cartilage repair2004

    • Author(s)
      Nakayama, K., Matsuda, S., Tanaka, K., Mizuchi, H., Iwamoto, Y
    • Organizer
      The 5th bi-annual meeting of International Cartilage Repair Society
    • Place of Presentation
      Gent, Belgium
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Scaffold free mesenchymal stem cell plug for autolgous repair of osteochondral defect in rabbit2004

    • Author(s)
      Nakayama, K., Matsuda, S., Tanaka, K., Iwamoto, Y
    • Organizer
      5th Combined Meeting of the Orthopaedic Research Societies of Canada, U.S.A. Japan and Europe
    • Place of Presentation
      Alberta, Canada
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] スポーツによる大腿・膝の障害・外傷(分担執筆)神中整形外科学(上巻)2004

    • Author(s)
      松田 秀一
    • Publisher
      南山堂
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 発育期の膝関節障害とスポーツ障害(分担執筆)神中整形外科学(下巻)2004

    • Author(s)
      松田 秀一
    • Publisher
      南山堂
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2004-04-01   Modified: 2016-04-21  

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