Osteochondral regeneration using autologous cell construct with β TCP

• Project/Area Number: 16591497
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Kyushu University
• Principal Investigator: MATSUDA Shuichi Kyushu University, Department of Orthopaedic Surgery, Assistant Professor (40294938)
• Project Period (FY): 2004 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥3,710,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥210,000); Fiscal Year 2007: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2006: ¥700,000 (Direct Cost: ¥700,000); Fiscal Year 2005: ¥1,000,000 (Direct Cost: ¥1,000,000); Fiscal Year 2004: ¥1,100,000 (Direct Cost: ¥1,100,000)
• Keywords: cartilage repair / mesenchymal stem cell / TCP / type II collagen / chondrocyte

Research Abstract

We established a new method to make cell only construct on TCP to repair osteochondral defect.
Mesenchymal stem cells (MSCs) were obtained from the iliac crest of Japanese-white-rabbit. Monolayer expanded cells were mold into a cylinder of 4.8mm in diameter and 4mm in height on TCP. The autologous labeled-MSC plug was implanted with TCP in the patellofemoral groove of the rabbit. The knees were immobilized for one week. The rabbits were sacrificed at 3, 6, 12, 24, and 52 weeks after operation. The specimens were evaluated histologically and scanned with micro CT.
In gross appearance of the cartilage at 6 weeks, most of the surface of the defect was covered with cartilage-like tissue. Smooth surfaces were maintained in regenerated cartilage at one year. Histologically, columnar distribution of the chondrocyte was observed in regenerated hyaline cartilage. In the subchondral bone level, endochondral ossification occurred at the peripheral area of the transplants, and small area in the central remained hyaline cartilage. Micro CT showed further ossification in subchondral bone level. Confocal microscopy detected the labeled cells both in cartilage layer and subchondral bone layer.
The current study suggests that this cell-delivery system can be used for treatment of osteochondral defect and possibly for osteoarthritis.

Research Products

• [Journal Article] Femoral shaft bowing influences the correction angle for high tibial osteotomy (2007)
  • Author(s): Nagamine R, Inoue S, Miura H, Matsuda S, et. al.
  • Journal Title: J Orthop Sci 12 Pages: 214-218
  • NAID: 10020157897
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Assessment of Anterolateral Rotatory Instability in the Anterior Cruciate Ligament-Deficient Knee Using an Open Magnetic Resonance Imaging System (2007)
  • Author(s): Okazaki K, Miura H, Matsuda S, et. al.
  • Journal Title: Am J Sports Med 35 Pages: 1091-1097
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Minimally invasive versus standard approach in total knee arthroplasty (2007)
  • Author(s): Tashiro Y, Miura H, Matsuda S, et. al.
  • Journal Title: Clin Orthop 463 Pages: 144-150
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 骨髄間葉系幹細胞を用いた骨軟骨複合組織の作成、および軟骨欠損の治療への応用 (2007)
  • Author(s): 松田秀一, 他
  • Journal Title: 日本整形外科スポーツ医学会雑誌 27 Pages: 215-221
  • NAID: 10025706009
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Femoral shaft bowing influences the correction angle for high tibial osteotomy (2007)
  • Author(s): Nagamine, R., Inoue, S., Miura, H., Matsuda, S., Iwamoto, Y
  • Journal Title: J Orthop Sci 12(3) Pages: 214-8
  • NAID: 10020157897
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Assessment of Anterolateral Rotatory Instability in the Anterior Cruciate Ligament-Deficient Knee Using an Open Magnetic Resonance Imaging System (2007)
  • Author(s): Okazaki, K., Miura, H., Matsuda, S., Yasunaga, T., Nakashima, H., Konishi, K., Iwamoto, Y., Hashizume, M
  • Journal Title: Am J Sports Med 35(7) Pages: 1091-7
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Minimally invasive versus standard approach in total knee arthroplasty (2007)
  • Author(s): Tashiro, Y., Miura, H., Matsuda, S., Okazaki, K., Iwamoto, Y
  • Journal Title: Clin Orthop 463 Pages: 144-150
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] 骨髄間葉系幹細胞を用いた骨軟骨複倉組織の作成、および軟骨欠損の治療への応用 (2007)
  • Author(s): 松田 秀一, 他
  • Journal Title: 日本整形外科スポーツ医学会雑誌 27 Pages: 215-221
  • Peer Reviewed
• [Journal Article] ナノクリスタルでラベリングした間葉系幹細胞の骨軟骨欠損部移植後の検出 (2006)
  • Author(s): 中山 功一、松田 秀一, 他
  • Journal Title: 日本整形外科学会雑誌 80 Pages: 1104-1104
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] -TCPと間葉系幹細胞を用いた広範囲関節軟骨再生の試み (2006)
  • Author(s): 中山 功一、松田 秀一, 他
  • Journal Title: 日本整形外科学会雑誌 80 Pages: 981-981
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] HMG-CoA還元酵素阻害剤(スタチン)は骨髄間葉系細胞の軟骨特異的遺伝子発現を促進する (2006)
  • Author(s): 赤崎 幸穂、松田 秀一, 他
  • Journal Title: 日本整形外科学会雑誌 80 Pages: 1106-1106
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Asymmetry of mediolateral laxity of the normal knee (2006)
  • Author(s): Okazaki K, Miura H, Matsuda S, et. al.
  • Journal Title: J Orthop Sci 11 Pages: 264-266
  • NAID: 10018362254
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Anteroposterior stability in posterior cruciate ligament-retaining total knee arthroplasty (2006)
  • Author(s): Mizu-uchi H, Matsuda S, et. al.
  • Journal Title: J Arthroplasty 21 Pages: 592-598
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] The extramedullary guide of the proximal tibia resection should be seen in front during total knee arthroplasty (2006)
  • Author(s): Nagamine R, Matsunobu T, Takayama M, Miura H, Matsuda S, et. al.
  • Journal Title: Fukuoka Acta Medica 97 Pages: 146-151
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Arthroscopic Resection of the Discoid Lateral Meniscus:Long-term Follow-up for16 Years (2006)
  • Author(s): Okazaki K, Miura H, Matsuda S, et. al.
  • Journal Title: Arthroscopy 97 Pages: 967-971
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Functional evaluation of four patients treated with V-Y quadricepsplasty in total knee arthroplasty (2006)
  • Author(s): Tsukamoto N, Miura H, Matsuda S, et. al.
  • Journal Title: J Orthop Sci 11 Pages: 94-400
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] The Effect of Ankle Rotation on Cutting Error of the Tibia in Total Knee Arthroplasty (2006)
  • Author(s): Mizu-uchi H, Matsuda S, et. al.
  • Journal Title: Journal of Bone and Joint Surg Am 88 Pages: 2632-2636
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Asymmetry of mediolateral laxity of the normal knee (2006)
  • Author(s): Okazaki, K., Miura, H., Matsuda, S., Takeuchi, N., Mawatari, T., Hashizume, M., Iwamoto, Y
  • Journal Title: J Orthop Sci 11(3) Pages: 264-266
  • NAID: 10018362254
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Anteroposterior stability in posterior cruciate ligament-retaining total knee arthroplasty (2006)
  • Author(s): Mizu-uchi, H., Matsuda, S., Miura, H., Nabeyama, R., Okazaki, K., Iwamoto, Y
  • Journal Title: J Arthroplasty 21 Pages: 592-598
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The extramedullary guide of the proximal tibia resection should be seen in front during total knee arthroplasty (2006)
  • Author(s): Nagamine, R., Matsunobu, T., Takayama, M., Miura, H., Matsuda, S., Iwamoto, Y
  • Journal Title: Fukuoka Acta Medica 97 Pages: 146-151
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] rthroscopic Resection of the Discoid Lateral Meniscus : Long-term Follow-up for 16 Years (2006)
  • Author(s): Okazaki, K., Miura, H., Matsuda, S., Hashizume, M., Iwamoto, Y
  • Journal Title: Arthroscopy 22(9) Pages: 967-971
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Functional evaluation of four patients treated with V-Y quadricepsplasty in total knee arthroplasty (2006)
  • Author(s): Tsukamoto, N., Miura, H., Matsuda, S., Mawatari, T., Kato, H., Iwamoto, Y
  • Journal Title: J Orthop Sci. 11(4) Pages: 394-400
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The Effect of Ankle Rotation on Cutting Error of the Tibia in Total Knee Arthroplasty (2006)
  • Author(s): Mizu-uchi, H., Matsuda, S., Miura, H., Higaki, H., Okazaki, K., Iwamoto, Y
  • Journal Title: J Bone and Joint Surg Am 88 Pages: 2632-6
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] ナノクリスタルでラベリングした間葉系肝細胞の軟骨欠損部移植後の検出 (2006)
  • Author(s): 中山功一, 松田秀一, 田仲和宏, 三浦裕正, 赤崎幸穂, 岩本幸英
  • Journal Title: 日本整形外科学会雑誌 80・8 Pages: 1104-1104
• [Journal Article] α-TCPと間葉系肝細胞を用いた広範囲関節軟骨再生の試み (2006)
  • Author(s): 中山功一, 松田秀一, 赤崎幸穂, 三浦裕正, 岩本幸英
  • Journal Title: 日本整形外科学会雑誌 80・8 Pages: 981-981
• [Journal Article] HMG-CoA還元酵素阻害剤(スタチン)は骨髄間葉系細胞の軟骨特異的遺伝子発現を促進する (2006)
  • Author(s): 赤崎幸穂, 松田秀一, 中山功一, 水内秀城, 深川真吾, 岩元幸英
  • Journal Title: 日本整形外科学会雑誌 80・8 Pages: 1201-1201
• [Journal Article] HMG-CoA還元酵素阻害剤(スタチン)は骨髄間葉系細胞の軟骨分化を促進する (2006)
  • Author(s): 赤崎幸穂, 松田秀一, 中山功一, 田仲和宏, 三浦裕正, 岩本幸英
  • Journal Title: 移植 41・5 Pages: 514-514
• [Journal Article] Scaflbldを用いない未分化間葉系幹細胞デリバリーシステムを用いた骨軟骨の再生 (2005)
  • Author(s): 中山 功一、松田 秀一, 他
  • Journal Title: 日本整形外科学会雑誌 79 Pages: 809-809
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Importance of the lateral anatomic tibial slope as a guide to the tibial cut in total knee arthroplasty in Japanese patients (2005)
  • Author(s): Kuwano T, Urabe K, Miura H, Nagamine R, Matsuda S, et. al.
  • Journal Title: J Orthop Sci. 10 Pages: 42-47
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Contact stress at the post-cam mechanism in posterior stabilized total knee arthro plasty (2005)
  • Author(s): Nakayama K, Matsuda S, et. al.
  • Journal Title: J Bone Joint Surg Br 87 Pages: 483-488
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Validity of an oblique posterior condylar radiographic view for revision total knee arthroplasty (2005)
  • Author(s): Miura H, Matsuda S, et. al.
  • Journal Title: J Bone Joint Surg Br 87 Pages: 1643-1646
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Importance of the lateral anatomic tibial slope as a guide to the tibial cut in total knee arthroplasty in Japanese patients (2005)
  • Author(s): Kuwano, T., Urabe, K., Miura, H., Nagamine, R., Matsuda, S., Satomura, M., Sasaki, T., Sakai, S., Honda, H., wamoto, Y
  • Journal Title: J Orthop Sci. 10(1) Pages: 42-7
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Contact stress at the post-cam mechanism in posterior stabilized total knee arthroplasty (2005)
  • Author(s): Nakayama, K., Matsuda, S., Miura, H., Higaki, H., Otsuka, K., Iwamoto, Y
  • Journal Title: J Bone Joint Surg Br 87(12) Pages: 1643-6
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Validity of an oblique posterior condylar radiographic view for revision total knee arthroplasty (2005)
  • Author(s): Miura, H., Matsuda, S., Okazaki, K., Kawano, T., Kawamura, Iwamoto, Y
  • Journal Title: J Bone Joint Surg Br 87(12) Pages: 1643-6
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Tracking implanted mesenchymal stem cells in vivo with nano-crystal reagents (2005)
  • Author(s): Nakayama K, Matsuda S, Y Akasaki, K Tanaka, H Miura, Y Iwamoto
  • Journal Title: Transaction of The 4th Annual Meeting of the European Tissue Engineering Society Pages: 19-19
• [Journal Article] Novel cell delivery system without carrier vehicle : Regeneration of rabbit ostes-chondral defect with autologous mesenchymal stem cell (2005)
  • Author(s): Nakayama K, Matsuda S, Y Akasaki, K Tanaka, H Miura, Y Iwamoto
  • Journal Title: Transactioin of The 8^<th> Annual Meeting of Tissue engineering Society International Pages: 152-152
• [Journal Article] Anatomical Analysis of the Femoral Condyle in Normal and Osteoarthritic Knees (2004)
  • Author(s): Matsuda S, et. al.
  • Journal Title: J Orthop Res 22 Pages: 104-109
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] The oblique posterior condylar radiographic view to evaluate the posterior femoral condyle following total knee arthroplasty (2004)
  • Author(s): Miura H, Matsuda S, et. al.
  • Journal Title: J Bone Joint Surg Am 86 Pages: 47-50
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] The Accuracy of computed tomography-based image-guided total knee arthroplasty (2004)
  • Author(s): Nabeyama R, Matsuda S, et. al.
  • Journal Title: Bone Joint Surg Br 86 Pages: 366-371
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Anatomical Analysis of the Femoral Condyle in Normal and Osteoarthritic Knees (2004)
  • Author(s): Matsuda, S., Miura, H., Nagamine, R., Mawatari, T., Tokunaga, M., Nabeyama, R., Iwamoto, Y
  • Journal Title: J Orthop Res 22 Pages: 104-109
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The oblique posterior condylar radiographic view to evaluate the posterior femoral condyle following total knee arthroplasty (2004)
  • Author(s): Miura, H., Matsuda, S., Mawatari, T., Kawano, T., Nabeyama, R., Iwamoto, Y
  • Journal Title: J Bone Joint Surg Am 86 Pages: 47-50
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The Accuracy of computed tomography-based image-guided total knee arthroplasty (2004)
  • Author(s): Nabeyama, R., Matsuda, S., Miura, H., Mawatari, T., Kawano, T., Iwamoto, Y
  • Journal Title: J Bone Joint Surg Br 86 Pages: 366-371
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] In Vivo Study of Scaffold Free Mesenchymal Stem Cell Plug for Cartilage Repair (2004)
  • Author(s): Nakayama K, Matsuda S, Tanaka K, Mizuchi H, Iwamoto Y
  • Journal Title: Transaction of the 5th bi-annual meeting of International Cartilage Repair Society Pages: 94-94
• [Journal Article] Scaffold Free Mesenchymal Stem Cell Plug for Autologous Repair of Osteo-Chondral Defect in Rabbit (2004)
  • Author(s): Nakayama K, Matsuda S, Tanaka K, Iwamoto Y
  • Journal Title: Transaction of 5th Combined Meeting of the Orthopaedic Research Societies of Canada, U.S.A., Japan and Europe Pages: 220-220
• [Presentation] HMG-CoA還元酵素阻害剤(スタチン)は骨髄間葉系細胞の軟骨分化を誘導する (2007)
  • Author(s): 赤崎 幸穂, 松田 秀一, 他
  • Organizer: 第20回 日本軟骨代謝学会
  • Place of Presentation: 岡山
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Scaffold free MSCデリバリーシステムを用いた骨軟骨再生の一年成績 (2007)
  • Author(s): 中山 功一、松田 秀一, 他
  • Organizer: 第20回日本軟骨代謝学会
  • Place of Presentation: 岡山
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] HMG-CoA還元酵素阻害剤(スタチン)は骨髄間葉系細胞の軟骨分化を誘導する (2007)
  • Author(s): 赤崎 幸穂, 松田 秀一, 他
  • Organizer: 第39回日本結合組織学会学術大会・第54回マトリックス研究会大会合同学術集会
  • Place of Presentation: 東京
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Statin induces chondrogenic differentiation in bone marrow stromal cells (2007)
  • Author(s): Akasaki Y, Matsuda S, et. al.
  • Organizer: The 53rd Annual Meeting of Orthopaedic ResearchSociety
  • Place of Presentation: San Diego,USA
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Overview of cartilage tissue engineering (2007)
  • Author(s): Nakayama K, Matsuda S, et. al.
  • Organizer: 15th Triennial Congress of Asia Pacific Orthopaedic Association
  • Place of Presentation: Scoul,Korea
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] One-year follow up of osteo-chondral regeneration in rabbit by scaffold free mesenchymal stem cell implantation (2007)
  • Author(s): Nakayama K, Matsuda S, et. al.
  • Organizer: One-year follow up of osteo-chondral regeneration in rabbit by scaffold free mesenchymal stem cell implantation
  • Place of Presentation: Warsaw,Poland
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Statin induces chondrogenic differentiation in bone marrow stromal cells (2007)
  • Author(s): Akasaki, Y., Matsuda, S., Nakayama, K., Mizu-uchi, H., Fukagawa, S., Iwamoto, Y
  • Organizer: The 53rd Annual Meeting of Orthopaedic Research Society
  • Place of Presentation: San Diego, USA
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] One-year follow up of osteo-chondral regeneration in rabbit by scaffold free mesenchymal stem cell implantation (2007)
  • Author(s): Nakayama, K., Matsuda, S., Akasaki, Y., Fukagawa, S., Iwamoto, Y
  • Organizer: 7th World Congress of International Cartilage Repair Society
  • Place of Presentation: Warsaw, Poland
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Overview of cartilage tissue engnieering (2007)
  • Author(s): Nakayama K, Matsuda S, et. al.
  • Organizer: 15^<th> Triennial Congress of Asia Pacific Orthopaedic Association
  • Place of Presentation: Seoul,Korea
• [Presentation] One-year follow up of osteo-chondral regeneration in rabbit by scaffold free mesenchymal stem cell implantation (2007)
  • Author(s): Nakayama K, Matsuda S, et. al.
  • Organizer: 7^<th> World Congress of International Cartilage Repair Society
  • Place of Presentation: Warsaw,Poland
• [Presentation] HMG-CoA還元酵素阻害剤(スタチン)は骨髄間葉系細胞の軟骨分化を促進する (2006)
  • Author(s): 赤崎 幸穂, 松田 秀一, 他
  • Organizer: 第25回 日本運動器移植・再生医学研究会
  • Place of Presentation: 東京
  • Year and Date: 2006-09-23
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Scaffbldを用いない未分化間葉系幹細胞デリバリーシステム用いた骨軟骨の再生 (2005)
  • Author(s): 中山 功一、松田 秀一、他
  • Organizer: 第20回日本整形外科学会基礎学術集会
  • Place of Presentation: 伊勢
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Tracking implanted mesenchymal stem cells in vivo with nano-crystalreagents (2005)
  • Author(s): Nakayama K, Matsuda S, et. al.
  • Organizer: The 4th Annual Meeting of the Europearn Tissue Engineering Society
  • Place of Presentation: Munich,Germany
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] -TCPと間葉系幹細胞を用いた広範囲関節軟骨再生の試み (2005)
  • Author(s): 中山 功一、松田 秀一, 他
  • Organizer: 第21回日本整形外科学会基礎学術集会
  • Place of Presentation: 長崎
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ナノクリスタルでラベリングした間葉系幹細胞の骨軟骨欠損部移植後の検出 (2005)
  • Author(s): 中山 功一、松田 秀一, 他
  • Organizer: 第21回日本整形外科学会基礎学術集会
  • Place of Presentation: 長崎
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] HMG-CoA還元酵素阻害剤(スタチン)は骨髄間葉系細胞の軟骨分化を誘導する (2005)
  • Author(s): 赤崎 幸穂, 松田 秀一, 他
  • Organizer: 第21回日本整形外科学会基礎学術集会
  • Place of Presentation: 長崎
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Tracking implanted mesenchymal stem cells in vivo with nano-cry stalreagents (2005)
  • Author(s): Nakayama, K., Matsuda, S., Akasaki, Y., Tanaka, K., Miura, H., Iwamoto, Y
  • Organizer: The 4th Annual Meeting of the Europearn Tissue Engineering Society
  • Place of Presentation: Munich, Germany
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 細胞単独からなる自家骨髄間葉系幹細胞プラグを用いた軟骨再生 (2004)
  • Author(s): 中山 功一、松田 秀一, 他
  • Organizer: 第23回日本運動器移植・再生医学研究会
  • Place of Presentation: 岡山
  • Year and Date: 2004-09-18
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 細胞単独からなる間葉系幹細胞プラグを用いた軟骨の再生 (2004)
  • Author(s): 中山 功一、松田 秀一, 他
  • Organizer: 第1回 福岡再生医療研究会
  • Place of Presentation: 福岡
  • Year and Date: 2004-05-31
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 細胞単独からなる骨軟骨様プラグの作成 (2004)
  • Author(s): 中山 功一、松田 秀一, 他
  • Organizer: 第17回日本軟骨代謝学会
  • Place of Presentation: 東京
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 細胞単独からなる間葉系幹細胞プラグを用いた軟骨の再生 (2004)
  • Author(s): 中山 功一、松田 秀一, 他
  • Organizer: 第36回日本結合組織学会学術大会
  • Place of Presentation: 福岡
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] In vivo study of scaffold free mesenchymal stem cell plug for cartilage repair (2004)
  • Author(s): Nakayama K, Matsuda S, et. al.
  • Organizer: The 5th bi-annual meeting of lnternational Cartilage Repair Society
  • Place of Presentation: Gent,Belgium
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Scaffold free mesenchymal stem cell plug for autolgous repair of osteochondral defect in rabbit (2004)
  • Author(s): Nakayama K, Matsuda S, et. al.
  • Organizer: 5th Combined Meeting of the Orthopaedic Research Societies of Canada, U.S.A., Japan and Europe
  • Place of Presentation: Alberta,Canada
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] In vivo study of scaffold free mesenchymal stem cell plug for cartilage repair (2004)
  • Author(s): Nakayama, K., Matsuda, S., Tanaka, K., Mizuchi, H., Iwamoto, Y
  • Organizer: The 5th bi-annual meeting of International Cartilage Repair Society
  • Place of Presentation: Gent, Belgium
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Scaffold free mesenchymal stem cell plug for autolgous repair of osteochondral defect in rabbit (2004)
  • Author(s): Nakayama, K., Matsuda, S., Tanaka, K., Iwamoto, Y
  • Organizer: 5th Combined Meeting of the Orthopaedic Research Societies of Canada, U.S.A. Japan and Europe
  • Place of Presentation: Alberta, Canada
  • Description: 「研究成果報告書概要(欧文)」より
• [Book] スポーツによる大腿・膝の障害・外傷(分担執筆)神中整形外科学(上巻) (2004)
  • Author(s): 松田 秀一
  • Publisher: 南山堂
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 発育期の膝関節障害とスポーツ障害(分担執筆)神中整形外科学(下巻) (2004)
  • Author(s): 松田 秀一
  • Publisher: 南山堂
  • Description: 「研究成果報告書概要(和文)」より