| Project/Area Number |
16591510
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Keio University |
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Principal Investigator |
SATO Kazuki Keio University, Dept. of Medicine, Assistant, 医学部, 助手 (60235322)
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| Co-Investigator(Kenkyū-buntansha) |
KAWAKITA Atsuo Keio University, Dept. of Medicine, Assistant, 医学部, 助手 (40338083)
MATSUO Kouichi Keio University, Dept. of Medicine, Associate professor, 医学部, 助教授 (40229422)
TOYAMA Yoshiaki Keio University, Dept. of Medicine, Professor, 医学部, 教授 (40129549)
NAKAMURA Toshiyasu Keio University, Dept. of Medicine, Assistant, 医学部, 助手 (70265859)
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2005: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2004: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | Growth plate / Fos / Knock out mouse / PTHrP / PTHrP |
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| Research Abstract |
It was confirmed that the epiphyseal plate of the Fos knock-out mouse was analyzed in detail, the proliferation layer was thin made compared with normal mouse (wild type), and the proliferation layer was thick in histology (The mouse of the age for seven weeks is used). It thinks this to be evidence to prove the Fos protein plays some roles in a differentiation of the epiphysial cartilage. Then we analyzed the epiphyseal plate of E 17.5 days mouse (both Fos knock-out mouse and wild type), and it was revealed that the histological findings were as same as those of the seven weeks mouse. This result suggests that the anomaly of the epiphyseal plate was not due to secondary effect of osteoclast, but due to direct effect of the absence of Fos protein.
Our assumption is that Fos protein plays an important role in the epiphyseal cartilage differentiation and perhaps, it exists in the downstream of PTHrP in the cascade of the cartilage proliferation in epiphysis.
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