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Effect of positive end-expiratory pressure on inflammatory response in oleic acid-induced lung injury and whole lung lavage-induced lung injury

Research Project

Project/Area Number 16591528
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionTokyo Medical and Dental University

Principal Investigator

NAKAZAWA Koichi  Tokyo Medical and Dental University, Department of Anesthesiology & Critical Care Medicine, Associate Professor, 大学院医歯学総合研究科, 助教授 (10207756)

Co-Investigator(Kenkyū-buntansha) YOKOYAMA Kuninori  Tokyo Medical and Dental University, Department of Anesthesiology & Critcal Care Medicine, Assistant Professor, 大学院医歯学総合研究科, 助手 (00014176)
Project Period (FY) 2004 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2005: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2004: ¥1,500,000 (Direct Cost: ¥1,500,000)
KeywordsARDS / PEEP / Oleic acid induced lung injury / Lung lavage / IL-8 / オレイン酸 / ventilator induced lung injury
Research Abstract

The present study investigated the effects of PEEP on two different lung injury models : edematous lung induced by oleic acid (OA); and atelectatic lung induced by whole lung lavage (LAV). Japanese white rabbits (n=28) were allocated into one of the two lung injury (OA or LAV) groups and each group was treated with intermittent positive pressure ventilation using zero end-expiratory pressure (ZEEP) or PEEP (1cmH2O above the lower inflection point). Therefore, animals were divided into LAV-ZEEP, LAV-PEEP, OA-ZEEP or OA-PEEP group. Blood and bronchoalveolar fluid were sampled 3 h after ventilatory treatment to analyze IL-8 levels. Main Results : PaO_2 was significantly decreased after induction of lung injury, but was significantly higher in PEEP groups compared to ZEEP groups in each lung injury. Serum IL-8 levels were elevated in both experimental models. Serum IL-8 levels were significantly lower in LAV-PEEP than in LAV-ZEEP, whereas no difference was noted between OA-PEEP and OA-ZEEP. BALF IL-8 levels were lower in LAV-PEEP than in LAV-ZEEP. PEEP above LIP attenuates elevation of IL-8 in BALF and serum in atelectatic lungs, but does not attenuate these increases in edematous lung. In conclusion, the protective effects of PEEP on injured lungs may depend on underlying lung pathology.

Report

(4 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (8 results)

All 2007 2004 2003

All Journal Article (8 results)

  • [Journal Article] Effect of positive end-expiratory pressure on inflammatory response in oleic acid-induced lung injury and whole lung lavage-induced lung injury.2007

    • Author(s)
      Nakazawa K, Yamakawa N, Yokoyama K, Makita K
    • Journal Title

      Journal of Anesthesia 21

      Pages: 47-54

    • NAID

      10018730219

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effect of positive end-expiratory pressure on inflammatory response in oleic acid-induced lung injury and whole lung lavage-induced lung injury.2007

    • Author(s)
      Nakazawa K, Yamakawa N, Yokoyama K, Makita K
    • Journal Title

      J Anesthesia 21

      Pages: 47-54

    • NAID

      10018730219

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effect of positive end-expiratory pressure on inflammatory response in oleic acid-induced lung injury and whole lung lavage-induced lunginjury.2007

    • Author(s)
      Nakazawa K, Yokoyama K
    • Journal Title

      Journal of Anesthesia 21

      Pages: 47-54

    • NAID

      10018730219

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Effects of partial liquid ventilation on lipopolysaccaride-induced inflammatory responses in rats.2004

    • Author(s)
      Anguelova M, Nakazawa K, Yokoyama K, Makita K
    • Journal Title

      Resuscitation 62

      Pages: 89-96

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effect of open lung approach on inflammatory responses in the lungs ; difference between oleic acid induced lung injury and lung injury induced by whole lung lavage.2004

    • Author(s)
      Nakazawa K, Yokoyama K, Murai K, Uchida T, Makita K
    • Journal Title

      Annual meeting of American Society of Anesthesiologist, 15 Oct 2004 Las Vegas

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effect of intraoperative prostaglandin E1 on proinflammatory responses and gas exchange in patients undergoing oesophageal cancer surgery.2004

    • Author(s)
      Nakazawa_K, Narumi Y, Ishikawa S
    • Journal Title

      Br J Anaesth 93

      Pages: 199-203

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Effects of partial liquid ventilation on lipopolysaccaride-induced inflammatory responses in rats.2004

    • Author(s)
      Anguelova M, Nakazawa K
    • Journal Title

      Resuscitation 62

      Pages: 89-96

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Effect of open lung approach on inflammatory responses in the lungs; difference between oleic acid induced lung injury and lung injury induced by whole lung lavage2003

    • Author(s)
      Nakazawa K, Yokoyama K, Murai K, Uchida T, Makita K
    • Journal Title

      Annual metting of American Society of Anesthesiologist (学会発表)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary

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Published: 2004-04-01   Modified: 2016-04-21  

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