| Project/Area Number |
16591545
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | The University of Tokushima |
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Principal Investigator |
KITAHATA Hiroshi The University of Tokushima, Institute of Health Biosciences, Associate Professor, 大学院・ヘルスバイオサイエンス研究部, 助教授 (60161486)
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| Co-Investigator(Kenkyū-buntansha) |
OSHITA Shuzo The University of Tokushima, Institute of Health Biosciences, Professor, 大学院・ヘルスバイオサイエンス研究部, 教授 (60144945)
KAWAHITO Shinji The University of Tokushima, University Medical and Dental Hospital, Instructor, 医学部・歯学部附属病院, 助手 (60284296)
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2005: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2004: ¥2,300,000 (Direct Cost: ¥2,300,000)
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| Keywords | Ultra-short-acting β1 blocker / Myocardial protecion / Landiolol / Sevoflurane / Propofol / ATP sensitive potassium channel / Anesthetic preconditioning / ケタミン |
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| Research Abstract |
The influence of anesthetics for the myocardial protection by a short-actiong β_1 blocker, landiolol was studied.
[2004]Animal experiments
Rabbits (n=25) were assigned to one of four experimental groups : ketamine (K) group, ketamine+landiolol (K+L) group, sevoflurane (S) group, and sevoflurane+landiolol (S+L) group. All rabbits were subjected to a 30-min coronary artery occlusion followed by 3-h reperfusion. Landiolol (20μg/kg/min) was intravenously administered in K+L and S+L groups from 30min before occlusion through the experiment. The infarct size of the area at risk in K+L group (42±11%) was reduced as compared with K group (59±4%). In S+L group, the myocardial infarct size (23±3%) was furthermore decreased significantly as compared with K group.
In mongrel dogs anesthetized with pentobarbital, the coronary blood flow of left circumflex was reduced to 80% of baseline. Landiolol (2μg/kg/min) was intravenously administered 15min after coronary stenosis. The partial pressure of oxygen in inner layer of myocardium decreased after stenosis, however, increased significantly 15min and 30min after landiolol administration (27.6±4.4mmHg, 30.0±5.2mmHg, respectively).
[2005]Clinical study
Fourteen patients undergoing vascular surgery were anesthetized with either sevoflurane (1MAC) or propofol (3μg/ml) combined with oxygen-nitrogen oxide (50%). One patient of propofol group showed both intraoperative ischemic change in ECG and left ventricular regional wall motion abnormality. Serum levels of troponin T, troponin I, and CK-MB were increased 12hr and 24hr after surgery in this patient.
Landiolol produced myocardial protection, which seemed to be enhanced under sevoflurane anesthesia.
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