| Project/Area Number |
16591555
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
HAYASHI Kazuko Kyoto Prefectural University of Medicine, Department of Anesthesiology, Assistant professor, 医学研究科, 助手 (40285276)
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| Co-Investigator(Kenkyū-buntansha) |
MURAI Toshiya Kyoto University, Department of Psychology, Associate professor, 医学研究科, 助教授 (30335286)
KATOU Ayako Tokyo Electric university, Department of science and engineering, Assistant professor, 理工学部, 助手 (30318159)
FUKUI Yasuhiro Tokyo Electric university, Department of science and engineering, Professor, 理工学部, 教授 (60112877)
TANAKA Yoshifumi Kyoto Prefectural University of Medicine, Department of Anesthesiology, Professor, 医学研究科, 教授 (50079935)
河端 恭代 京都府立医科大学, 医学研究科, 助手 (70347467)
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2005: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2004: ¥2,100,000 (Direct Cost: ¥2,100,000)
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| Keywords | Pupil fluctuation / autonomic nerve activity / awakening degree / Sympathetic nerve activity / electroencephalogram analysis / eye movement / pain / regulation of the pupil size |
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| Research Abstract |
The purpose of the study is to examine the function of the brain including thalamus and hypothalamus, by the pupil fluctuation.
It was shown that a quantity of pupil fluctuation increased by stress sleepless. The cycle of pupil fluctuation of the time was about 1Hz. On the other hand, in a physically unimpaired person, the emotional loading test did not cause the meaningful change of pupil fluctuation.
Concerning the awaking process from anesthesia, the difference about the pupil fluctuation was not seen between the intravenous anesthesia (propofol) and the volatile anesthesia (sevoflurane), both of which are GABA agonist. However, in the case of ketamine which was NMDA antagonist, the lability of eye movement itself was recognized in an awakening process. A consciousness state is controlled by processing source of information and nerve modification action in addition to an activation level of a brain. The source of information means the relative balance between outside source and internal source, and can be recognized with movement of the eye, which is a substitute for the PGO-wave. Therefore, the result may suggest that NMDA-antagonist affects the gating of input/output system in the brain.
Furthermore, in the spectral analysis simultaneously performed, ketamine, an NMDA-antagonist, increased the spindle peak of the α-band (which was usually induced by GABA-agonist) to 4 Hz higher. In the phase analysis to examine the phase coupling at that time, the peak of the bicoherence also shifted to 3-4Hz higher on the frequency domain.
The result suggest that ketamine work the reticular thalamic network as constituting the consciousness. The result showed that the measurements of the fluctuation of pupil and eye movement are important to examine the awaking consciousness, together with electroencephalogram.
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