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The therapeautic effects of general anesthetics with NMDA receptor blocking properties on postoperative cognitive decline.

Research Project

Project/Area Number 16591564
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionYokohama City University (2006)
Teikyo University (2004-2005)

Principal Investigator

GOTO Takahisa  Yokohama City University, Graduate School of Medicine, Professor, 医学研究科, 教授 (00256075)

Co-Investigator(Kenkyū-buntansha) ISHIGURO Yoshiki  Teikyo University, School of Medicine, Professor, 医学部, 教授 (40232285)
TAKADA Shinji  Teikyo University, School of Medicine, Assistant Professor, 医学部, 講師 (90226788)
SAKAMOTO Hidetoshi  Teikyo University, School of Medicine, Instructor, 医学部, 助手 (90349267)
MORITA Shigeho  Teikyo University, School of Medicine, Professor, 医学部, 教授 (60143476)
花田 諭史  帝京大学, 医学部, 助手 (10365976)
Project Period (FY) 2004 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2006: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2005: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2004: ¥1,700,000 (Direct Cost: ¥1,700,000)
KeywordsXenon / Cognitive Decline / NMDA receptor / 手術 / 麻酔
Research Abstract

We investigated the effects of two general anesthetics with N-methyl-D-aspartate (NMDA) receptor blocking properties, ketamine and xenon, postoperative cognitive decline in 65 patients who were older than 60 and underwent major abdominal or orthopedic surgeries. Anesthesia consisted of (1) nitrous oxide and sevoflurane (control group, n=21), (2) nitrous oxide and sevoflurane plus a continuous infusion of ketamine at 511g・kg-1・mind (ketamine group, n=22) or (3) xenon 60% plus sevoflurane (xenon group, n=22). Cognitive function was evaluated by using the Mini-Mental State Examination and the Symbol-Digit Substitution and the Digit-Span subsets of the revised Wechsler Adult Intelligence tests (WAIS-R). Cognitive function was I evaluated preoperatively, 2weeks after surgery, and 6 months after surgery. Cognitive decline was predefined as the worsening of the score of any test of greater than 20% compared to the preoperative value. Furthermore, the plasma level of S-100b protein, the biomarker of cerebral injury, was measured preoperatively, at the end of operation, and 48 hours postoperatively.
At two weeks postoperatively, the number of patients who demonstrated cognitive decline was 6/21 (control), 7/22 (ketamine), and 4/22 (xenon). The difference was not statistically significant. At 6 months postoperatively, the number was 3/17 (control), 4/20 (ketamine), and 2/18 (xenon). The plasma level of 5-100b protein was not different among the three anesthetic groups.
In conclusion, neither ketamine nor xenon had therapeautic effects on the postoperative congnitive dysfunction in the elderly surgical patients. However, the number of the patients enrolled was too small to draw any definite conclusions.

Report

(4 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • 2004 Annual Research Report

Research Products

(11 results)

All 2006 2005 2004

All Journal Article (11 results)

  • [Journal Article] The effects of xenon on myogenic motor evoked potentials in rabbits : A Comparison with propofol and isoflurane.2006

    • Author(s)
      Yamamoto Y, Kawaguchi M, Goto T, Furuya H, 他3名
    • Journal Title

      Anesthesia and Analgesia 102

      Pages: 1715-1721

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The effects of xenon on myogenic motor evoked potentials in rabbits : A Comparison with propofol and isoflurane.2006

    • Author(s)
      Yamamoto Y, Kawaguchi M, Kakimoto M, Takahashi M, Inoue S, Goto T, Furuya H
    • Journal Title

      Anesthesia and Analgesia 102

      Pages: 1715-1721

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The effects of xenon on myogenic motor evoked potentials in rabbits : A Comparison with propofol and isoflurane.2006

    • Author(s)
      Yamamoto Y, Kawaguchi M, Goto T, Furuya H, 他3名
    • Journal Title

      Anesthesia and Analgesia 102.

      Pages: 1715-1721

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Nitrogen accumulation during closed circuit anesthessia depends on the type of surgery.2005

    • Author(s)
      Hanne P, Goto T, Nakata Y, Ishisuro Y, Morita S
    • Journal Title

      Journal of Clinical Anesthesia 17

      Pages: 504-508

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The bispectral analysis of the electroencephalogram predicts responsiveness to verbal command in patients emerging from nitrons oxide-isoflurane anesthesia2005

    • Author(s)
      Goto T, Ishiguro Y, Nakata Y, Morita S
    • Journal Title

      Journal of Anesthesia 15・2

      Pages: 102-105

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The bispectral analysis of the electroencephalogram predicts responsiveness to verbal command in patients emerging from nitrous oxide-isoflurane anesthesia.2005

    • Author(s)
      Goto T, Ishiguro Y, Nakata Y, Morita S
    • Journal Title

      Journal of Anesthesia 19 (2)

      Pages: 102-5

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Nitrogen accumulation during closed circuit anesthessia depends on the type of surgery.2005

    • Author(s)
      Hanne P, Goto T, Nakata Y, Ishiguro Y, Morita S
    • Journal Title

      Journal of Clinical Anesthesia 17

      Pages: 504-8

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The present and the future of xenon in medicine.2005

    • Author(s)
      Goto T, Nakata Y, Morita S
    • Journal Title

      The 2005 Workshop on Application of Rare Gas Xenon to Science and Technology (XeSAT2005), Tokyo

    • NAID

      110002514956

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Clinical pharmacology of xenon in anesthesia.2005

    • Author(s)
      Nakata Y, Goto T, Morita S
    • Journal Title

      The 2005 Workshop on Application of Rare Gas Xenon to Science and Technology (XeSAT2005), Tokyo

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The cardiovascular effects of xenon and nitrous oxide in patients under fentanyl-midazolam anaesthesia.2004

    • Author(s)
      Goto T, Hanne P, Ishiguro Y, Ichinose F, Niimi Y, Morita S
    • Journal Title

      Anaesthesia 59・12

      Pages: 1178-1183

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The cardiovascular effects of xenon and nitrous oxide in patients under fentanyl-midazolam anaesthesia.2004

    • Author(s)
      Goto T, Hanne P, Ishiguro Y, Ichinose F, Niimi Y, Morita S
    • Journal Title

      Anaesthesia 59

      Pages: 1178-83

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary

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Published: 2004-03-31   Modified: 2016-04-21  

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