| Project/Area Number |
16591568
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Anesthesiology/Resuscitation studies
|
|---|
| Research Institution | Nihon University |
|---|
Principal Investigator |
KATO Jitsu Nihon University, MEDICINE, ASSOCIATE PROFESSOR (10224510)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KASHIWAZAKI Miho NIHON UNIVERSITY, MEDICINE, RESEARCH ASSISTANT (60328739)
IWASAKI Kenichi NIHON UNIVERSITY, MEDICINE, ASSOCIATE PROFESSOR (80287630)
|
|---|
| Project Period (FY) |
2004 – 2006
|
| Project Status |
Completed (Fiscal Year 2006)
|
| Budget Amount *help |
¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 2006: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2005: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2004: ¥1,600,000 (Direct Cost: ¥1,600,000)
|
|---|
| Keywords | pediatrics / inguinal hernia / anesthesia / ilioinguinl nerve block / Ropivacaine / MBPS / heart rate variability analysis / ChromograninA / 鼡径ヘルニア / 腸骨鼡径神経ブロック / HRV / クロモグラニンA / 鼠径ヘルニア手術 |
|---|
| Research Abstract |
We investigated the effects of ilioinguinal-iliohypogastric nerve block on postoperative pain in pediatric patients undergoing inguinal surgery using 0.5% or 0.2% ropivacaine by means of modified behavior pain scale (MBPS), salivary chromogranin A (CgA) and heart rate variability (HRV). After being approved by the Ethical Committee of the institute and getting the written informed parental consent, thirty children, aged 2-5 years, were enrolled in our prospective double-blinded randomized controlled study. Thirty children for elective unilateral inguinal surgery were randomized to receive 0.6ml/kg of either 0.5%ropivacaine (0.5%R group) or 0.2%ropivacanien (0.2%R group). General anesthesia was inducted and maintained with mask inhalation oxygen, nitrous oxide and sevoflurane. After induction ilioinguinal-iliohypogastric (II-IH) nerve block were performed. The day before surgery heart rate variability (HRV) was measured using electrocardiography and also the sample of saliva for measuri
… More
ng the concentration of CgA was taken. At three and six hours after surgery the children were evaluated by means of MBPS to estimate pain intensity, giving a total score of between 0 and 10. At the same time HRV and CgA were measured. Demographic data is not significant difference in the two groups. The median values of MBPS scale was below 2 at 3 and 6hours after surgery in the two groups. No additional any analgesic was used after surgery. The values of CgA in the two groups were no difference at all points. The values of HRV were varied widely in both groups. Therefore it was difficult to estimate post-operative pain based on the results of HRV. It is concluded that preincisional II-IH nerve block with 0.2% ropivacaine provided equally effective pain relief as 0.5% ropivacaine. We recommend 0.2% ropivacaine for Ilioinguinal-Iliohypogastric nerve block in pediatric inguinal surgery. In addition, it is considered that a salivary CgA may be a new indicator to estimate post operative pain. Less
|
