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EFFECTS OF NERVE SPEARING OPERATION IN TERMS OF FUNCTIONAL ANATOMY ON PRESERVATION FOR ERECTILE, EJACULATING AND BLADDER FUNCTIONS

Research Project

Project/Area Number 16591581
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionGunma University

Principal Investigator

ITO Kazuto (2005)  GUNMA UNIVERSITY, UROLOGY, ASSOCIATE PROFESSOR, 大学院・医学系研究科, 助教授 (00302472)

黒川 公平 (2004)  群馬大学, 医学部, 講師 (50225281)

Co-Investigator(Kenkyū-buntansha) SUZIKI Kazuhiro  GUNMA UNIVERSITY, UROLOGY, PROFESSOR, 医学系研究科, 教授 (80312891)
伊藤 一人  群馬大学, 大学院・医学系研究科, 講師 (00302472)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2005: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 2004: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywordsfunctional anatomy / voiding function / sexual function / nerve stimulation system / nerve spearing operation / QOL / 機能解剖 / 勃起能 / 膀胱機能 / 骨盤内悪性腫瘍手術 / 温存評価
Research Abstract

It was demonstrated that nerve spearing surgery without using nerve stimulation system could not expect postoperative genitourinary function. The out standing point on the current study is to carry out an objective evaluation on nerve spearing technique in terms of intravesical or intracavernous pressure immediately after electronic stimulation.
In 2005, almost all research was done using simple and reasonable commercial based-stimulating system made by FKSS, which was authorized by The Ministry of Labor and Welfare in Japan in 2004. The stimulation system is of advantages in its cost and usage, because some settings on stimulation are limited. The limited settings are followings ; stimulating frequency is fixed at 10Hz, which may result the most effective stimulation on nerve response in canine model. Duration of stimulation is fixed at 0.2m sec, which may be of the best recovery on stimulated nerve in animal models. Current in stimulation can be set at 5, 10, 20 or 30mA. The setting on the current stimulating system make maximal stimulation be possible, then it may result effective stimulation in any time we want without deactivation on stimulated nerve.
This stimulating system has been used in 8 cases having undergone gynecological operation, so far. The system always worked well. In the future, more cases should be tested in clinical settings using this system.
All issues on this research were approved by the ethical committee in Gunma University. Furthermore, all analyses on this research were done without all individual information on privacy.

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (17 results)

All 2006 2005 2004 Other

All Journal Article (17 results)

  • [Journal Article] Pelvic autonomic nerve mapping around the prostate by intraoperative electrical stimulation with simultaneous measurement of intracavernous and intraurethral pressure.2006

    • Author(s)
      Takenaka A, Tewari A, Hara R, Leung RA, Kurokawa K, et al.
    • Journal Title

      The Journal of Urology In press

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Intraoperative electrical stimulation of the pelvic splanchnic nerves during nerve-sparing radical hysterectomy.2005

    • Author(s)
      Katahira A, Niikura H, Kaiho Y, Kurokawa K, et al.
    • Journal Title

      Gynecologic Oncology 98,3

      Pages: 462-466

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Prostate carcinoma detection and increased prostate-specific antigen levels after 4 years in Dutch and Japanese males who had no evidence of disease at initial screening.2005

    • Author(s)
      Ito K, et al.
    • Journal Title

      Cancer 103

      Pages: 242-250

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Effectiveness of adjuvant intermittent endocrine therapy following neoadjuvant endocrine therapy and external beam radiation therapy in men with locally advanced prostate cancer.2005

    • Author(s)
      Yamanaka H, Ito K, et al.
    • Journal Title

      Prostate 63

      Pages: 56-64

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Acute genitourinary toxicity after high-dose-rate brachytherapy combined with hypofractionated external-beam radiation therapy for localized prostate cancer : Correlation between the urethral dose in HDR brachytherapy and the severity of acute genitourinary toxicity.2005

    • Author(s)
      Akimoto T, Ito K, Suzuki K, et al.
    • Journal Title

      Int J Radiat Oncol Biol Phys 63

      Pages: 463-471

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Intraoperative electrical stimulation of the pelvic splanchnic nerves during nerve-sparing radical hysterectomy.2005

    • Author(s)
      Katahira A, Niikura H, Kaiho Y, Kurokawa K, Arai Y, Yaegashi N
    • Journal Title

      Gynecologic Oncology 98,3

      Pages: 462-466

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Prostate carcinoma detection and increased prostate-specific antigen levels after 4 years in Dutch and Japanese males who had no evidence of disease at initial screening.2005

    • Author(s)
      Ito K.et al.
    • Journal Title

      Cancer 103

      Pages: 242-250

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Acute Genitourinary toxicity after high-dose-rate brachytherapy combined with hypofractionated external-beam radiation therapy for localized prostate cancer : Correlation between the urethral dose in HDR brachytherapy and the severity of acute genitourinary toxicity.2005

    • Author(s)
      Akimoto T, Ito K.Saitoh J, Noda S, Harashima K, Sakurai H, Nakayama Y, Yamamoto T, Suzuki K, et al.
    • Journal Title

      Int J Radiat Oncol Biol Phys 63

      Pages: 463-471

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Acute genitourinary toxicity after high-dose-rate brachyhtherapy combined with hypofractionated external-beam radiation therapy for localized prostate cancer : Correlation between the urethral dose in HDR brachytherapy and the severity of acute genitourinary toxicity.2005

    • Author(s)
      Akimoto T, Ito K, Suzuki K, et al.
    • Journal Title

      Int J Radiat Oncol Biol Phys 63

      Pages: 463-471

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Acute genitourinary toxicity after high-dose-rate brachyhtherapy combined with hypofractionated external-beam radiation therapy for localized prostate cancer : Second analysis to determine the correlation between the urethral dose in HDR brachytherapy and the severity of acute genitourinary toxicity.2005

    • Author(s)
      Akimoto T, Ito K, et al.
    • Journal Title

      Int J Radiat Oncol Biol Phys 63

      Pages: 472-478

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Insulin-like growth factor binding protein-6 inhibits prostate cancer cell proliferation : Implication for anticancer effect of diethylstilbestrol in hormone refractory prostate cancer.2005

    • Author(s)
      Koike H, Ito K, Suzuki K, et al.
    • Journal Title

      Br J Cancer 292

      Pages: 1538-1544

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 前立腺癌検診のインファームド・コンセントと将来展望2005

    • Author(s)
      伊藤一人
    • Journal Title

      泌尿器外科 18

      Pages: 897-900

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 勃起神経と射精神経走行。および尿禁制に関与する自律神経走行に関して2005

    • Author(s)
      黒川 公平, 武井智幸, 田中俊之, 伊藤 一人, 鈴木和浩
    • Journal Title

      臨床解剖研究会記録 No5

      Pages: 14-15

    • Related Report
      2004 Annual Research Report
  • [Journal Article] External beam radiotherapy for clinically node-negative, localized hormone-refractory prostate cancer : Impact of pretreatment PSA value on radiotherapic outcomes2004

    • Author(s)
      T.Akimoto, …, K.Kurokawa, …
    • Journal Title

      Int.J.Rad.Oncol.Biol.Phys. 59.2

      Pages: 372-378

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Rectal bleeding after hypofractionated radiotherapy for prostate cancer : Correlation between clinical and dosimetric parameters and the incidence of grade 2 or worse rectal bleeding2004

    • Author(s)
      T.Akimoto, …, K.Kurokawa, …
    • Journal Title

      Int.J.Rad.Oncol.Biol.Phys. 60.4

      Pages: 1033-1039

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Utility of CT during arteriography in superselective transarterial chemoembolization for invasive bladder cancer2004

    • Author(s)
      A.Ishibashi, …, K.Kurokawa, …
    • Journal Title

      Kitakanto Med J 54

      Pages: 81-86

    • NAID

      110001463797

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Pelvic autonomic nerve mapping around the prostate by intraoperative electrical stimulation with simultaneous measurement of intracavernous and intraurethral pressure.

    • Author(s)
      Takenaka A, Tewari A, Hara R, Leung RA, Kurokawa K, Murakami G, Fujisawa M
    • Journal Title

      Journal of Urology (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary

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Published: 2004-04-01   Modified: 2016-04-21  

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