Research for appropriate use of interferon for renal cell carcinoma

• Project/Area Number: 16591585
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Urology
• Research Institution: The University of Tokyo
• Principal Investigator: KUME Haruki The University of Tokyo, The University of Tokyo Hospital, Associate professor (10272577)
• Co-Investigator(Kenkyū-buntansha): KITAMURA Tadaichi The University of Tokyo, The University of Tokyo Hospital, Professor (70010551)
• Project Period (FY): 2004 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥2,760,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥60,000); Fiscal Year 2007: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000); Fiscal Year 2006: ¥500,000 (Direct Cost: ¥500,000); Fiscal Year 2005: ¥900,000 (Direct Cost: ¥900,000); Fiscal Year 2004: ¥1,100,000 (Direct Cost: ¥1,100,000)
• Keywords: Renal cell carcinoma / type I interferon / Interferon receptor / インターフェロン / IFNR1 / IFNR2 / 発現 / IFNAR1 / IFNAR2

Research Abstract

Type I Interferon is widely used for advanced renal cell carcinoma (RCC). In some uses without metastasis, interferon is used for adjuvant situation. However interferon is expensive and appropriate usage is required. Here, we examined expression of interferon receptors in cases with RCC.
Type I interferon receptor is dimeric and composed of INFAR1 and INFAR2. We performed RT-PCR in peripheral blood, renal tumor, and non-neoplastic renal tissue of 19 RCC cases and one renal angiomyolipoma case.
RT-PCR showed significant correlation of expression of INFAR1 in peripheral blood, renal tumor, and non-neoplastic renal tissue. Also, there was a significant correlation of expression of IFNAR2 in peripheral blood, renal tumor, and non-neoplastic renal tissue.
However, there was no correlation of the expression of receptors with clinical parameters including LDH, ALP, Hemoglobin, tumor grade, and tumor stage.
These data suggest that expression of receptors in peripheral blood reflects in tumor tissue and that we may examine only the expression of peripheral blood. Also, no correlation with clinical parameters suggests the expression of receptors might be a new prognostic marker.

Research Products

• [Journal Article] 腎細胞癌に対するインターフェロン治療の適正化に関する研究 (2008)
  • Author(s): 久米春喜
  • Journal Title: 大和証券ヘルス財団研究業績集 31 Pages: 23-27
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Research for appropriate use of interferon for renal cell carcinoma (2008)
  • Journal Title: Daiwa Securities Group Foundation for Health Vol31 Pages: 23-27
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Salvage combination chemotherapy with docetaxel, ifosfamide and cisplatin (DIP): successful treatment of a case with metastatic testicular immature teratoma. (2008)
  • Author(s): Related Articles, LinksKume H, Kakutani S
  • Journal Title: Jpn J Clin Oncol 38 Pages: 143-145
  • Peer Reviewed
• [Journal Article] The effect of combined androgen blockade on bone turnover and bone mineral density in men with prostate cancer. (2008)
  • Author(s): Yamada Y, Takahashi S, Fujimura T, Nishimatsu H, Ishikawa A, Kume H, Tomita K, Takeuchi T, Kitamura T.
  • Journal Title: Osteoporos Int 19 Pages: 321-327
  • Peer Reviewed
• [Journal Article] Identification of Toll-like receptor 3 as a potential therapeutic target in clear cell renal cell carcinoma. (2007)
  • Author(s): Related Articles, LinksMorikawa T, Sugiyama A, Kume H, Ota S, Kashima T, Tomita K, Kitamura T, Kodama T, Fukayama M, Aburatani H
  • Journal Title: Clin Cancer Res 13 Pages: 5703-5709
  • Peer Reviewed
• [Journal Article] The prognostic value of E-cadherin, alpha-, beta- and gamma-catenin in bladder cancer patients who underwent radical cystectomy. (2007)
  • Author(s): Kashibuchi K, Tomita K, Schalken JA, Kume H, Takeuchi T, Kitamura T.
  • Journal Title: Int J Urol. 14 Pages: 789-794
  • Peer Reviewed
• [Journal Article] Plasma cell granuloma of urethra in a young woman. (2007)
  • Author(s): Yokoyama H, Kume H, Niimi A, Tomota K, Kitamura T.
  • Journal Title: Am J Obstet Gynecol. 196(3)
• [Journal Article] Improvement of endothelial function with allopurinol may occur in selected patients with OSA : effect of age and sex. (2007)
  • Author(s): Teramoto S, Kume H, Yamaguchi Y, Yamamoto H, Hanaoka Y, Ishii M, Ishii T, Ouchi Y.
  • Journal Title: Eur Respir J. 29(1) Pages: 216-7
• [Journal Article] Predictors of seminal vesicle invasion before radical prostatectomy. (2006)
  • Author(s): Tsurumaki Y, Tomita K, Kume H, Yamaguchi T, Morikawa T, Takahashi S, Takeuchi T, Kitamura T.
  • Journal Title: Int J Urol. 13(12) Pages: 1501-8
  • NAID: 10018440593
• [Journal Article] Reference values for 6-min walk distance in Asian adults may not be different from that of Caucasian adults. (2006)
  • Author(s): Teramoto S, Kume H, Ishii T, Yamamoto H, Yamaguchi Y, Ishii M, Hanaoka Y, Ouchi Y.
  • Journal Title: Respirology 11(5) Pages: 671-2
• [Journal Article] Heart rate variation analysis may not effectively detect sleep apnoeas in heart failure. (2006)
  • Author(s): Teramoto S, Kume H, Yamaguchi Y, Yamamoto H, Ishii M, Ishii T, Ouchi Y.
  • Journal Title: Eur Respir J. 28(2) Pages: 458-8
• [Journal Article] Irinotecan as a new agent for urachal cancer. (2006)
  • Author(s): Kume H, Tomita K, Takahashi S, Fukutani K.
  • Journal Title: Urol Int. 76(3) Pages: 281-2
• [Journal Article] Bladder recurrence of upper urinary tract cancer after laparoscopic surgery. (2006)
  • Author(s): Kume H, Teramoto S, Tomita K, Nishimatsu H, Takahashi S, Takeuchi T, Ota N, Kitamura T
  • Journal Title: J Surg Oncol 93(4) Pages: 318-22
• [Journal Article] The prognostic value of E-cadherin, alpha-, beta-, and gamma-catenin in urothelial cancer of the upper urinary tract. (2006)
  • Author(s): Kashibuchi K, Tomita K, Schalken JA, Kume H, Yamaguchi T, Muto S, Horie S, Kitamura T.
  • Journal Title: Eur Urol. 49(5) Pages: 839-45
• [Journal Article] Bladder recurrence of upper urinary tract cancer after laparoscopic surgery (2006)
  • Author(s): Kume H, Teramoto S, Tomita K et al.
  • Journal Title: Journal of Surgical Oncology 93 Pages: 318-322
• [Journal Article] The Prognostic Value of E-Cadherin, alpha-, beta-, and gamma-Catenin in Urothelial Cancer of the Upper Urinary Tract. (2006)
  • Author(s): Kashibuchi K, Tomita K, Schalken JA, Kume H, Yamaguchi T, Muto S, Horie S, Kitamura T.
  • Journal Title: Eur Urol. Jan, 6(in press)
• [Journal Article] Irinotecan as a New Agent for Urachal Cancer (2006)
  • Author(s): Kume H, Takahashi S, Tomita K, Fukutani K
  • Journal Title: Urologiz Internationalis (In press)
• [Journal Article] Xanthoma of the urinary bladder. (2005)
  • Author(s): Kobayashi F, Kume H, Tomita K, Kitamura T.
  • Journal Title: Scand J Urol Nephrol. 39(6) Pages: 527-528
• [Journal Article] Combination chemotherapy of docetaxel, ifosfamide and cisplatin (DIP) in patients with metastatic urothelial cancer : a preliminary report. (2005)
  • Author(s): Takahashi S, Suzuki M, Kume H, Matsumoto S, Okamoto N, Nishimatsu H, Tomita K, Kitamura T.
  • Journal Title: Jpn J Clin Oncol. 35(2) Pages: 79-83
• [Journal Article] A problematic complication of sex change operation (2005)
  • Author(s): Nyomura S, Tomita K, Kume H, Nishimatsu H, Takahashi S, Takeuchi T, Kitamura T.
  • Journal Title: Surgery 138(3) Pages: 543-544
• [Presentation] インターフェロン(IFN)αレセプターの腎細胞癌における発現 (2006)
  • Author(s): 久米春喜
  • Organizer: 第44回日本癌治療学会
  • Place of Presentation: 東京
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Expression oftype I interferon receptor in renal cell carcinoma (2006)
  • Organizer: 44^<th> annual meeting, Japan Society of Clinicl Oncology
  • Place of Presentation: Tokyo
  • Description: 「研究成果報告書概要(欧文)」より