| Project/Area Number |
16591587
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | University of Fukui |
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Principal Investigator |
OYAMA Nobuyuki University of Fukui, University of Fukui Hospital, Lecturer, 医学部附属病院, 講師 (20223977)
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| Co-Investigator(Kenkyū-buntansha) |
YOKOYAMA Osamu University of Fukui, Faculty of Medical Sciences, Professor, 医学部, 教授 (90242552)
OKAZAWA Hidehiko University of Fukui, Biomedical Imaging Research Center, Associate Professor, 高エネルギー医学研究センター, 助教授 (50360813)
MATSUTA Yousuke University of Fukui, Faculty of Medical Sciences, Assistant Professor, 医学部, 助手 (90345687)
TANASE Kazuya University of Fukui, University of Fukui Hospital, Assistant Professor, 医学部附属病院, 助手 (00359720)
AOKI Yoshitaka University of Fukui, University of Fukui Hospital, Assistant Professor, 医学部附属病院, 助手 (30273006)
楠川 直也 福井大学, 医学部附属病院, 助手 (80372499)
前川 正信 福井大学, 医学部, 助手 (50362041)
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2005: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2004: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | complicated cyst / renal cancer / ^<11>C-acetate / PET / FDG / 11C-Acetate / RNA干渉 / ^<18>F-FDG |
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| Research Abstract |
INTRODUCTION : Patients with complicated renal cysts present a diagnostic dilemma. Renal cancer with multiple renal cysts would be amenable to nephrectomy with curative intent, whereas cystic disease would be followed with watchful waiting. In this study, we evaluated the effectiveness of positron emission tomography (PET) with ^<11>C-acetate (AC) for evaluation of patients with complicated renal cysts. We also compared the reliability of AC-PET in detecting renal cancer with that of PET with ^<18>F-fluorodeoxyglucose (FDG). METHODS : Thirteen patients with complicated renal cysts were enrolled in this study. Following administration of 10 mCi of 11C-acetate, whole-body PET images were obtained. After allowing for 11C decay, 5 mCi of FDG was administered and repeat whole-body imaging was performed. The PET studies were scored as positive or negative in the kidney. PET findings were correlated with CT. RESULTS : Histological confirmation was confirmed in 11 patients. Six patients were diagnosed as renal cell carcinoma after surgery. Three of 6 patients with renal cell carcinoma (50%) had positive AC-PET findings, while only 1 FDG-PET study was positive (16%). Surgical specimens showed two patients had different type of tumour ; one patient had squamous cell carcinoma and the other had metastatic tumour. AC-PET showed positive finding for metastatic renal tumour, while FDG-PET was negative. None of these cases without malignant renal tumour had positive AC-PET or FDG-PET findings. CONCLUSION : AC-PET demonstrates marked uptake in renal cancer and higher sensitivity than FDG-PET. These preliminary data show that ^<11>C-acetate is a possible PET tracer for detection of renal tumour.
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