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Immunopathological analysis of influence of cytomegalovirus to acute rejection after renal transplantation

Research Project

Project/Area Number 16591609
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionFukushima Medical University

Principal Investigator

ISHIBASHI Kei  Fukushima Medical University, Department of Microbiology, Assistant Professor, 医学部, 助手 (90347211)

Co-Investigator(Kenkyū-buntansha) TOMA Hiroshi  Tokyo Women's Medical University, Department of urology, Professor, 腎臓病総合医療センター, 教授 (90075549)
SUZUTANI Tatsuo  Fukushima Medical University, Department of Microbiology, Professor, 医学部, 教授 (40196895)
YANAGIDA Tomohiko  Fukushima Medical University, Department of Urology, Assistant Professor, 医学部, 助手 (20363765)
徳本 直彦  東京女子医科大学, 泌尿器科, 助手 (30246540)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2005: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2004: ¥2,500,000 (Direct Cost: ¥2,500,000)
Keywordsrenal transplantation / cytomegalovirus / acute rejection / antigenemia / glycoprotein H / 糖タンパクB
Research Abstract

1.BACKGROUND : The impact of cytomegalovirus (CMV) superinfection with different serotypes on renal transplantation and the differences between CMV superinfection and primary infection or reactivation are still unknown.
2.METHODS : Serum samples from 114 renal transplant recipients and the 114 donors were analyzed for serotype specific antibodies against a CMV glycoprotein epitope. The pairings were categorized into CMV primary infection, superinfection and reactivation groups according to their antibody responses. We examined the association between CMV-infection type and acute rejection and CMV disease.
3.RESULTS : Among the 114 renal transplant pairings, 24 were categorized into the primary infection group, 48 into the reactivation group and 26 into the superinfection group according to serotype specific antibodies titers. The viral load of recipients quantified using pp65 antigenemia assay after transplantation were significantly higher in the superinfection and primary infection groups compared with that in the reactivation group (p<0.0001). The rate of CMV disease in antigenemia-positive cases was also significantly higher in the primary infection and superinfection groups compared with that in the reactivation group (P=0.006 and P=0.013, respectively). However, the rate of acute rejection was higher in the superinfection group (62 percent) compared with primary infection group (25 percent)(P=0.008, Fisher's exact test) and reactivation group (23 percent)(P=0.001).
4.CONCLUSIONS : Preoperative grouping of CMV infection by serotype specific antibodies can predict the risk of acute rejection as well as CMV disease after renal transplantation.

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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