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Elucidation of natural history of women having human papillomavirus infection in their uterine cervix without cervical neoplasia

Research Project

Project/Area Number 16591637
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionUniversity of Tsukuba

Principal Investigator

SATOH Toyomi  University of Tsukuba, Graduate School of Comprehensive Human Sciences, Assistant professor (80344886)

Co-Investigator(Kenkyū-buntansha) YOSHIKAWA Hiroyuki  University of Tsukuba, Graduate School of Comprehensive Human Sciences, professor (40158415)
Project Period (FY) 2004 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,810,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2006: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2005: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2004: ¥1,500,000 (Direct Cost: ¥1,500,000)
KeywordsHuman papillomavirus / cervical cancer / oncogenic type of HPV / 自然史 / 細胞診正常 / 子宮がん検診 / 二次検診 / リスクファクター / Human Papillomavirus
Research Abstract

To obtain baseline data for human papillomavirus (HPV) screening and vaccination in Japan, we analyzed HPV DNA data from 2282 Japanese women [1517 normal cytology, 318 CIN1 (cervical intraepithelial neoplasia grade 1), 307 CIN2-3 and 140 ICC (invasive cervical cancer)] that visited the University of Tsukuba Hospital or lbaraki Seinan Medical Center Hospital for screening or treatment of cervical diseases between 1999 and 2007. An L1-based PCR method was employed for individual HPV genotyping. The most common HPV types in ICC were, in order of decreasing prevalence, HPV16 (40.5%), 18 (24.4%), 52 (8.4%), 58 (3.1%) and 33 (3.1%). Based on the comparison of HPV type distributions between normal cytology and CIN2-3/ICC, estimated risk of disease progression varied considerably by genotype : HPV16/18/31/33/35/52/58 (the prevalence ratio ; 1.92, 95%CI 1.58-2.34) ; other oncogenic types (0.31, 95%CI 0.19-0.50) ; non-oncogenic types (0.09, 95%CI 0.03-0.43). HPV16 and/or 18, including co-infections with other types, contributed to 67.1% of ICC and 36.2% of CIN2-3 among Japanese women. More importantly, the overall prevalence of HPV16 and/or 18 varied greatly according to the women's age : highest in women aged 20-29 years (ICC 90.0% ; CIN2-3 53.9%), decreasing with age thereafter and lowest in women aged 60 years or older (ICC 56.3% ; CIN2-3 25.0%). In conclusion, type-specific HPV testing may help identify Japanese women at high risk of progression to CIN2-3 and cancer. In Japan, current HPV vaccines are estimated to provide approximately 70% protection against ICC and may be more useful in reducing the incidence of cervical cancer and precancer in young women of reproductive age.

Report

(5 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (34 results)

All 2009 2008 2007 2006 2005 2004

All Journal Article (6 results) (of which Peer Reviewed: 1 results) Presentation (28 results)

  • [Journal Article] Human Papillomavirus Infections among Japanese Women : Age-Related Prevalence and Type-Specific Risk for Cervical Cancer2009

    • Author(s)
      Mamiko Onuki, Koji Matsumoto, Toyomi Satoh, et al.
    • Journal Title

      Cancer Science 100

      Pages: 1312-1316

    • NAID

      10027192443

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Human Papillomavirus Infections among Japanese Women : Age-Related Prevalence and Type-Specific Risk for Cervical Cancer2009

    • Author(s)
      Mamiko Onuki, Koji Matsumoto, Toyomi Satoh, Akinori Oki, Satoshi Okada, Takeo Minaguchi, Hiroyuki Ochi, Sari Nakao, Katsumi Someya, Naoki Yamada, Hiromi Hamada, Hiroyuki Yoshikawa
    • Journal Title

      Cancer Science 100

      Pages: 1312-1316

    • NAID

      10027192443

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Do we need a difference strategy for HPV screening and vaccination in East Asia?2006

    • Author(s)
      Miura S, Satoh T, et al.
    • Journal Title

      Int J Cancer 119巻11号

      Pages: 2713-2715

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 性感染症の診断・治療と予防 9.ヒトパピローマウイルス2005

    • Author(s)
      佐藤豊実、小貫麻美子、山田直樹, ら
    • Journal Title

      産科と婦人科 72

      Pages: 877-883

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The diagnosis, treatment, prevention : 9. Human papillomavirus2005

    • Author(s)
      Toyomi Satoh, Mamiko Onuki, Naoki Yamada, et al.
    • Journal Title

      Obstet.Gynecol.<Tokyo> 72

      Pages: 877-883

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] ヒトパピローマウイルス2005

    • Author(s)
      佐藤豊実, 小貫麻美子, 山田直樹, 沖 明典, 吉川裕之
    • Journal Title

      産科と婦人科 72巻7号(in press)

    • Related Report
      2005 Annual Research Report 2004 Annual Research Report
  • [Presentation] Human Papillomavirus Infections among Japanese Women : Age-Related Prevalence and Type-Specific Risk for Cervical Cancer2008

    • Author(s)
      Mamiko Onuki, Koji Matsumoto, Toyomi Satoh, et al.
    • Organizer
      The 3rd biennial conference of Asia Oceania research organization on genital infection and neoplasia
    • Place of Presentation
      ソウル市(大韓民国)
    • Year and Date
      2008-05-29
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Human papillomavirus infections among Japanese women : Age-Related prevalence and type-specific risk for cervical cancer2008

    • Author(s)
      Mamiko Onuki, Koji Matsumoto, Toyomi Satoh, Akinori Oki, Satoshi Okada, Naoki Yamada, Hiromi Hamada, Hiroyuki Yoshikawa
    • Organizer
      The 3rd biennial conference of Asia Oceania research organization on genital infection and Neoplasia
    • Place of Presentation
      Seoul
    • Year and Date
      2008-05-29
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 若年HPV感染者の子宮頸部細胞診像(ワークショップ)2007

    • Author(s)
      佐藤豊実, 小貫麻美子, 福島美穂, ら
    • Organizer
      第46回日本臨床細胞学会 秋季大会
    • Place of Presentation
      仙台
    • Year and Date
      2007-11-30
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The Cytological findings of in young patients having HPV infection(Workshop)2007

    • Author(s)
      Toyomi Satoh, Mamiko Onuki, Miho Fukushima, et al.
    • Organizer
      The 46th annual meeting of the Japanese society of clinical cytology, in autumn
    • Place of Presentation
      Sendai
    • Year and Date
      2007-11-30
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 若年HPV感染者の子宮頸部細胞診像(ワークショップ)2007

    • Author(s)
      佐藤豊実, 他
    • Organizer
      日本臨床細胞学会
    • Place of Presentation
      仙台
    • Year and Date
      2007-11-30
    • Related Report
      2007 Annual Research Report
  • [Presentation] 子宮頸部病変術後、細胞診とHPV検査により再燃(再発)を早期発見した2例2007

    • Author(s)
      内山直樹、佐藤豊実、他
    • Organizer
      日本臨床細胞学会関東連合学術集会
    • Place of Presentation
      新潟
    • Year and Date
      2007-11-30
    • Related Report
      2007 Annual Research Report
  • [Presentation] 子宮頸部病変術後、細胞診とHPV検査により再燃(再発)を早期発見した2例2007

    • Author(s)
      内山直樹, 佐藤豊実, 福島美穂, ら
    • Organizer
      第21回日本臨床細胞学会関東連合会学術集会
    • Place of Presentation
      新潟
    • Year and Date
      2007-09-15
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Case report : Early detection of the recurrences after cervical resection for CIN3 by HPV typing and pap smear testing in two patients2007

    • Author(s)
      Naoki Uchiyama, Toyomi Satoh, Miho Fukushima, et al.
    • Organizer
      The 21st annual meeting of the Japanese society of clinical cytology, The Kanto federation
    • Place of Presentation
      Niigata
    • Year and Date
      2007-09-15
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 子宮頸部円錐切除後の細胞診とHPV検査2007

    • Author(s)
      福島美穂, 佐藤豊実, 内山直樹, ら
    • Organizer
      第48回日本臨床細胞学会
    • Place of Presentation
      東京
    • Year and Date
      2007-06-07
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The relationships between the HPV infection and the cytological findings in the patients after the cone biopsy2007

    • Author(s)
      Miho Fukushima, Toyomi Satoh, Naoki Uchiyama, et al.
    • Organizer
      The 48th annual meeting of the Japanese society of clinical cytology
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-06-07
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 子宮頸部円錐切除後の細胞診とHPV検査2007

    • Author(s)
      福島美穂、佐藤豊実、他
    • Organizer
      日本臨床細胞学会
    • Place of Presentation
      幕張
    • Year and Date
      2007-06-07
    • Related Report
      2007 Annual Research Report
  • [Presentation] 集団検診要精検者のHPV感染と短期 follow-up 成績2007

    • Author(s)
      小貫麻美子, 佐藤豊実, 安倍梓, ら
    • Organizer
      第59回日本産科婦人群会総会・学術講演会
    • Place of Presentation
      京都
    • Year and Date
      2007-04-16
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The investigation of the rate of HPV infection and outcome of the patients who required a close examination by screening during short period follow-up2007

    • Author(s)
      Mamiko Onuki, Toyomi Satoh, Azusa Abe, et al.
    • Organizer
      The 59th Annual Congress of the Japan Society of Obstetrics and Gynecology
    • Place of Presentation
      Kyoto
    • Year and Date
      2007-04-16
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 集団検診要精検者のHPV感染と短期follow-up成績2007

    • Author(s)
      小貫麻美子、佐藤豊実, 他
    • Organizer
      日本産科婦人科学会
    • Place of Presentation
      京都
    • Year and Date
      2007-04-16
    • Related Report
      2007 Annual Research Report
  • [Presentation] 増加する若年子宮頸癌患者とHPV感染(シンポジウム:HPV感染と子宮頸癌)2006

    • Author(s)
      佐藤豊実
    • Organizer
      第24回日本産婦人科感染症研究会
    • Place of Presentation
      新潟
    • Year and Date
      2006-06-10
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Increase of the prevalence of the uterine cervical carcinoma and the women who having HPV infection in young age. (Symposium : HPV infection and Uterine cervical carcinoma)2006

    • Author(s)
      Toyomi Satoh
    • Organizer
      The 24th annual meeting of the Japanese study group of infection in obstetrics and gynecology
    • Place of Presentation
      Niigata
    • Year and Date
      2006-06-10
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The relationships between the HPV infection and the cytological findings in the patients after the cone biopsy2006

    • Author(s)
      Miho Fukushima, Toyomi Satoh, Naoki Uchiyama, et al.
    • Organizer
      The 47th annual meeting of the Japanese society of clinical cytology
    • Place of Presentation
      Yokohama
    • Year and Date
      2006-06-09
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] HPV感染率に影響する危険因子の検討2006

    • Author(s)
      小貫麻美子, 佐藤豊実, 中村佳子, ら
    • Organizer
      第58回日本産科婦人科学会総会・学術講演会
    • Place of Presentation
      横浜
    • Year and Date
      2006-04-22
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The investigations of the risk factors for HPV infection2006

    • Author(s)
      Mamiko Onuki, Toyomi Satoh, Yoshiko Nakamura, et al.
    • Organizer
      The 58th Annual Congress of the Japan Society of Obstetrics and Gynecology
    • Place of Presentation
      Yokohama
    • Year and Date
      2006-04-22
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 子宮頸部円錐切除後のHPV感染と細胞像2006

    • Author(s)
      福島美穂, 佐藤豊実, 内山直樹, ら
    • Organizer
      第47回日本臨床細胞学会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] HPV感染率と初交年齢、性交パートナー数の関連2005

    • Author(s)
      佐藤豊実, 小貫麻美子, 山田直樹, ら
    • Organizer
      日本性感染症学会第18回学術集会
    • Place of Presentation
      北九州
    • Year and Date
      2005-12-03
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The investigation of relationship between HPV infection and the age of sexual debut and the number of sexual partner2005

    • Author(s)
      Toyomi Satoh, Mamiko Onuki, Naoki Yamada, et al.
    • Organizer
      The 18nd Annual meeting of Japanese society for sexually transmitted infections
    • Place of Presentation
      Kitakyushu
    • Year and Date
      2005-12-03
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 細胞診陰性でHPV陽性者の短期 follow-up の検討2005

    • Author(s)
      小貫麻美子, 佐藤豊実, 八木洋也, ら
    • Organizer
      第57回日本産科婦人科学会総会・学術講演会
    • Place of Presentation
      京都
    • Year and Date
      2005-04-03
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The investigation of outcome of the patients with HPV infection having normal pap smear in their uterine cervix during short period follow-up2005

    • Author(s)
      Mamiko Onuki, Toyomi Satoh, Hiroya Yagi, et al.
    • Organizer
      The 57th Annual Congress of the Japan Society of Obstetrics and Gynecology
    • Place of Presentation
      Kyoto
    • Year and Date
      2005-04-03
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 子宮頸部HPV陽性者における細胞診Class I/IIとClass IIIaでの進展の比較2004

    • Author(s)
      小貫麻美子, 佐藤豊実, 高橋佳子, ら
    • Organizer
      第42回日本癌治療学総会・学術集会
    • Place of Presentation
      京都
    • Year and Date
      2004-10-29
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The comparison of progression rate between Class I/II and Class IIIa as the results of pap smear in the patients having HPV infection in their uterine cervix2004

    • Author(s)
      Mamiko Onuki, Toyomi Satoh, Yoshiko Takahashi, et al.
    • Organizer
      The 42th Annual Meeting of the Japan Society of Clinical Oncology
    • Place of Presentation
      Kyoto
    • Year and Date
      2004-10-29
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 子宮頸部細胞診正常かつHPVDNA陽性者のHPV持続感染ないし消失の検討2004

    • Author(s)
      小貫麻美子, 佐藤豊実, 竹内沢子, ら
    • Organizer
      第56回日本産科婦人科学会総会・学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2004-04-13
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The investigation of the outcome of the HPV infection in the patients having normal pap smear of their uterine cervix2004

    • Author(s)
      Mamiko Onuki, Toyomi Satoh, Sawako Takeuchi, et al.
    • Organizer
      The 56th Annual Congress of the Japan Society of Obstetrics and Gynecology
    • Place of Presentation
      Tokyo
    • Year and Date
      2004-04-13
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2004-04-01   Modified: 2016-04-21  

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