| Project/Area Number |
16591668
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | KYUSHU UNIVERSITY |
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Principal Investigator |
AMADA Satoshi Kyushu University, University Hospital, Research Associate, 大学病院, 助手 (10294919)
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| Co-Investigator(Kenkyū-buntansha) |
HIRAKAWA Toshio Kyushu University, University Hospital, Assistant Professor, 大学病院, 講師 (20218770)
KOBAYASHI Hiroaki Kyushu University, University Hospital, Research Associate, 大学病院, 助手 (70260700)
SONODA Kenzo Kyushu University, University Hospital, Research Associate, 大学病院, 助手 (30294929)
SASAKI Masayuki Kyushu University, Department of Medicine, Professor, 医学部, 教授 (40240907)
KOGA Hirohumi Kyushu University, University Hospital, Research Associate, 大学病院, 助手 (90343318)
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 2005: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2004: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | early cervical cancer / sentinel lymph node / micrometastasis |
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| Research Abstract |
[Purpose] The purpose of this study was to investigate the feasibility of sentinel node (SN) detection by ^<99m>Tc-phytate and blue dye in patients with uterine cervical cancer undergoing radical hysterectomy. [Patients and Methods] 27 patients with cervical cancer were enrolled in this study (squamous cell carcinoma in 18cases and adenocarcinoma in 9cases, 16 were in stage Ib 1, 7 in Ib2 and 4 in stage IIb). Patients' age ranged from 20 to 71 years (median 48 years). On the day before surgery, we injected 37MBq of^<99m>Tc-phytate in each quadrant of the cervical submucosa around the tumor. Lymphoscintigraphy was performed for visualization of hot nodes 30, 45 and 60 minutes after injection. During the surgery, hot nodes and blue nodes were detected also by using hand-held gamma probe and blue dye method injecting indigo carmine in the cervix, respectively [Results] SNs were detected in 25 (92.5%), 25 and 16 (59.3%) patients by lymphoscintigraphy, gamma probe and blue dye method, respectively. SNs by lymphoscintigraphy were best visualized at 60 minutes after injection. Microscopically, lymph node metastases were observed in 6 cases. In 2 of these cases, no SN was detected by any technique, in which the cervix was totally replaced by bulky tumor tissue. Therefore, there was no false negative sentinel node in 25 SN detected cases. [Conclusion] This study shows that identification of SN in cancer of uterine cervix is best feasible with the combination of preoperative lymphoscintigraphy at 60 minutes and intraoperative gamma probe. The sentinel lymph node theory in cervical cancer will be valid in the near future.
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