| Research Abstract |
The purpose of this research is to evaluate risks of human papillomaviruses (HPVs), its subtypes or variants to induce cervical malignancy by determining HPV sequences in the cervical samples of invasive carcinoma (histologically, squamous cell carcinoma), cerviclal dysplasia (histologically, mild, moderate, severe dysplasia), and control group (normal cytology).
(1)High-risk types and variants
Thirty-one HPV types were detected in the carcinoma, dysplasia, and control groups of the total of about 4,000 samples. Of which, seventeen types were classified as high risk. There existed variants in twenty-six HPV types. The risk of malignancy may be different among variants.
(2)Detected HPV types
In carcinoma group, major HPVs were type16 (42.4%), type33 (9.0%), type 58 (8.0%), type18 (7.7%), type52 (7.1%), type31 (6.1%), and type35 (4.2%). High incidence of type58 and type52 was characteristic of the carcinoma population. In control group, major HPVs were type52 (12.0%), type51 (8.4%), type35 (8.1%), type53 (5.7%), type56 (5.4%), type16 (4.8%), type33 (3.6%), type90 (3.6%), type91 (3.6%), and type71 (3.0%). High incidence of type52, type51, type53, type56, type90, type91, and type71 was characteristic of the control population.
(3) Risk of each HPV type
High-risk HPVs were type16, type18, type31, type33, type35, type45, type51, type52, type53, type56, type58, type59, type66, type68, type70, type73, and type82, as determind by odds ratios calculated from comparison of carinoma group versus control group. Low-risk HPVs were type6, type32, type39, type42, type54, type61, type67, type71, type72, type84, type86, type90, and type91. Types 71, 90, 91, previously uncharacterized, were classified as low-risk genotypes, which is consisitent with predictions made on the basis of phylogeny.
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