| Budget Amount *help |
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 2005: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2004: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Research Abstract |
Cytokines are important regulatory mediators secreted by T cells and other immunoactive cells. Based on the cytokine synthesis patterns, CD4 T cells can often be classified into at least two populations with different immune regulatory functions. Th1 cells, producing IL-2 and IFN-γ, are often associated with cell-mediated immune responses such as DTH, whereas Th2 cells, secreting IL-4, IL-5, IL-13, usually provide B cell help and enhance allergic reactions. Naive CD8 T cells, similar to CD4 T cells, can differentiate into at least two subsets of cytolytic effector cells with distinct cytokine patterns. Tc1 cells secrete a Th1-like cytokine pattern, including IL-2 and IFN-γ^^~. Tc2 cells produce Th2 cytokines, including IL-4, IL-5 and Il-10. There is increasing evidence that Th1/Th2 and Tc1/Tc2 cytokine imbalance has been of pathogenetic importance in various diseases, such as allergic and autoimmune diseases. The present review article focuses on the evidence that the imbalance of Th1/Th2 and Tc1/Tc2 cytokines play important role in various otolaryngological diseases, such as Kimura's disease, Wegener's granulomatosism, acute perceptive hearing loss and Menier's disease. It is concluded that the predominance of Th1 and Th2 and Tc1 and Tc2 cells might contribute to the mechanism in pathogenesis of these otolaryngological diseases.
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