| Project/Area Number |
16591698
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
TAKEUCHI Naonobu The University of Tokyo, The University of Tokyo Hospital, Assistant Professor (40280945)
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| Co-Investigator(Kenkyū-buntansha) |
KONDO Kenji The University of Tokyo, Hospital, Assistant Professor (40334370)
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2005: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2004: ¥2,500,000 (Direct Cost: ¥2,500,000)
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| Keywords | Alzheimer's disease / model mouse / olfactory disturbance / tau protein / olfactory epithelium / olfactory bulb / immunohistochemistry / アルツハイマー病モデルマウス / 嗅粘膜 / メチマゾール / 行動実験 / 免疫組織学 / BrdU / アポトーシス |
|---|
| Research Abstract |
We investigated the changes of olfactory mucosa and olfactory bulb of a mouse model (transgenic mouse) for Alzheimer's disease. This mouse exhibits over expression of the tau protein in CNS. Immnohistochemical staining was performed with phosphate tau protein antibody (PS199) and bromodeoxyuridine (BrdU). PS199 immunoreactivity was found in the upper part of the olfactory cell layer of the epithelium, olfactory nerve bundles and olfactory bulbs even in mice 8 months after birth. On the other hand, BrdU immunoreactivity was weak in the bottom part of the olfactory cell layer. These results indicate that the changes in the olfactory epithelium and olfactory bulb are similar to those in the CNS of this mouse model. Also, olfactory disturbance may happen in this mouse model.
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