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A study of the influence of chemoradiation for head and neck cancer on healing of wound

Research Project

Project/Area Number 16591700
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionKanazawa University

Principal Investigator

TATSUTOMI Shinji (2006)  School of Medicine, Assistant, Professor, 医学部附属病院, 助手 (40359716)

西村 俊郎 (2004-2005)  金沢大学, 医学部附属病院, 講師 (80251958)

Co-Investigator(Kenkyū-buntansha) 達富 真司  金沢大学, 医学部附属病院, 助手 (40359716)
Project Period (FY) 2004 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2006: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2005: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2004: ¥2,100,000 (Direct Cost: ¥2,100,000)
Keywordshead and neck cancer / chemoradiation / healing of wound / animal study / 頭頚部癌
Research Abstract

Twenty C3H mice were anesthetized by intraperitoneal injection of Nembutal, and irradiated to dorsum skin (each 10 mice to 10Gy, 20Gy, 30Gy). To analyze the histological change, paraffin sections of dorsum skin were prepared for Hematokxylin and Eosin stain and Elastica van Gieson stain. As a result, the degeneration, defluvium, and disappearance of hair root was observed. In epidermis the decrease of cell layer and the atrophy were observed.
The expression of Notch receptor (Notch-1), ligand of Notch receptor (Jagged-1), cycloxygenase (COX-1, and COX-2) were immunohistologically analyzed at post-irradiation day 7, 30, and 90. Notch receptor regulates the differentiation and maintenance of cells by binding to its ligand. Jagged-1 activates the signals suppressing the differentiation and accelerates the migration of various cells. COX-1 homeostatically exist in vivo, whereas the expression of COX-2 was induced by stress, inflammation, and so on. At post-irradiation day 7, the expression of Notch-1 and Jagged was strongly recognized by hair root.The expression of COX-1 and COX-2 was less observed. At post-irradiation day 30, the expression of Jagged-1 was locally observed by hair root, whereas the expression of Notch-1 extended to stratum corneum. The expression of COX-1 and COX-2 was strongly observed in fibroblasts. At post-irradiation day 90, fibrous degeneration of dorsum skin was markedly recognized and the expression of these substances was decreased.
This study demonstrates that tissue is degenerated by inflammation due to irradiation at early post-irradiation time, and then inflammation gradually decreases and fibrous degeneration proceeds.

Report

(4 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (14 results)

All 2007 2005 2004

All Journal Article (14 results)

  • [Journal Article] 口腔底癌 late T2・T3の化学療法・放射線治療2007

    • Author(s)
      達富真司, 古川 仭, 吉崎智一
    • Journal Title

      JOHNS 23・4

      Pages: 649-652

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 「研究成果報告書概要(欧文)」より2007

    • Author(s)
      Shinji Tatsutomi, Mitsuru Furukawa, Tomokazu Yoshizaki
    • Journal Title

      JOHNS 23・4

    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 口腔底癌lateT2・T3症例の治療-化学療法、放射線療法2007

    • Author(s)
      達富 真司, 古川 仭, 吉崎 智一
    • Journal Title

      JOHNS 23.4(印刷中)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Cervical radiculopathy due to intra-arterial infusion of cisplatin2005

    • Author(s)
      Toshiro Nishimura, Jun-ichiro Sanada, Mitsuru Furukawa
    • Journal Title

      Journal of Laryngology & Otology 119・8

      Pages: 649-650

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 鼻性眼窩内合併症の5症例2005

    • Author(s)
      達富真司, 塚谷才明, 三輪高喜, 古川 仭
    • Journal Title

      日本鼻科学会会誌 44・4

      Pages: 302-308

    • NAID

      10017175818

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Cervical radicuropathy due to intra-arterial infusion of cisplatin2005

    • Author(s)
      Toshiro Nishimura, Mitsuru Furukawa
    • Journal Title

      Journal of Laryngology & Otology 119・8

      Pages: 649-650

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Five cases with orbital complications from acute sinusitis.2005

    • Author(s)
      Shinji Tatsutomi, Toshiaki Tsukatani, Takaki Miwa, Mitsuru Furukawa
    • Journal Title

      Japanese Journal of Rhinology 44・4

      Pages: 302-308

    • NAID

      10017175818

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Cervical radiculopathy due to intra-arterial infusion of cisplatin2005

    • Author(s)
      Nishimura, T., Sanada, J., Furukawa, M.
    • Journal Title

      Journal of Laryngology & Otology 119.8

      Pages: 649-650

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 当科での下咽頭喉頭全摘術後に遊離空腸にて再建した進行下咽頭癌の治療成績2004

    • Author(s)
      西村俊郎, 山田和宏, 三輪高喜, 古川 仭
    • Journal Title

      日本気管食道科学会報 55

      Pages: 253-257

    • NAID

      10013294157

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Scapular bone flap harvests of patients in a supine position.2004

    • Author(s)
      Nishimura T, Furukawa M
    • Journal Title

      Laryngoscope 114

      Pages: 1130-1132

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 腹腔鏡下採取の大網による頭頸部再建2004

    • Author(s)
      西村俊郎, 山田和宏, 伊藤真人, 三輪高喜, 古川 仭
    • Journal Title

      日本耳鼻咽喉科学会報 107

      Pages: 658-664

    • NAID

      80016719146

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 仰臥位で採取した肩甲骨、広背筋連合皮弁での再建の経験2004

    • Author(s)
      西村俊郎, 三輪高喜, 古川 仭
    • Journal Title

      頭頸部外科 14

      Pages: 145-149

    • NAID

      10025710359

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Soft tissue augmentation with laparoscopically harvested omentum2004

    • Author(s)
      Nishimura, T, Kanehira, E
    • Journal Title

      Br J Plast Surg 57

      Pages: 369-370

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Total necrosis of tongue due to severe haemorrhage.2004

    • Author(s)
      Nishimura T, Shimizu Y, Sanada J, Furukawa M.
    • Journal Title

      J Laryngol Otol 118

      Pages: 246-247

    • Related Report
      2004 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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