| Project/Area Number |
16591704
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
MINETA Hiroyuki Hamamatsu University School of Medicine, Professor, 医学部, 教授 (40190714)
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| Co-Investigator(Kenkyū-buntansha) |
MINERA Katsuyoshi Hamamatsu University, Hospital, Associate Professor, 医学部附属病院, 助教授 (20173974)
TAKEBAYASHI Satoru Hamamatsu University, Hospital, Assistant Professor, 医学部附属病院, 講師 (70283356)
SASAKI Yutaka Hamamatsu University, Hospital, Instructor, 医学部附属病院, 助手 (40324363)
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2005: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2004: ¥2,300,000 (Direct Cost: ¥2,300,000)
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| Keywords | HPV / carcinogenesis / head and neck cancer |
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| Research Abstract |
Human Papilloma Virus (HPV) is closed related with head and neck squamous cell carcinaomas(HNSCC). We reported the incidence of HPV among HNSCCs using in situ hybridization method, and showed the highest one is oropharyngeal cancer.
The HPV type consisted of malignant type (16,18,31 and so on) and benign type (6,11,56 and so on). Among HNSCC we detected the highest is HPV 16.
HPV E2 which is destructed is not able to inhibit E6 and E7 genes, so E6 and E7 combines p53 and Rb genes respectively
Now we research HPV E2 gene transfect into Hella and Caski cell lines.
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