| Project/Area Number |
16591714
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kochi University |
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Principal Investigator |
KAKIGI Akinobu Kochi University, Medical School Hospital, Assistant Professor, 医学部附属病院, 講師 (60243820)
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| Co-Investigator(Kenkyū-buntansha) |
TAKEDA Taizo Kochi University, Medical School, Professor, 医学部, 教授 (50115763)
澤田 正一 高知大学, 医学部, 助手 (90363275)
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2005: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2004: ¥2,700,000 (Direct Cost: ¥2,700,000)
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| Keywords | Meniere's disease / potassium ion / endolymphatic hydrops |
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| Research Abstract |
The pathological feature of Meniere's disease is endolymphatic hydrops. However, the causes of symptoms during Meniere's attacks remain unclear. One hypothesis of the Meniere's attack is that endolymphatic hydrops causes perilymphatic potassium increase and the potassium has a toxic effect on the eighth nerve.^<1,2> The results from temporal bone histopathology of Meniere's disease that include the rupture of the Reissner's membrane support this hypothesis. If it is the case, high K^+ of endolymph should leak into scala vestibuli. The higher K^+ in scala vestibuli could propagate into scala tympani through the spiral ligament and, in apical regions, through the helicotrema. However, the cause of K^+ leakage from endolymph could occur not only from a rupture of the Reissner's membrane but also from a permeability change of the cochlear duct without rupture, suggested by observations that Reissner's membrane ruptures are not observed in all temporal bones following attacks. The purpose of this study is to investigate the relationship between endolymphatic hydrops and perilymphatic potassium under conditions without Reissner's membrane rupture.
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