• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Study on elucidation of the mechanism of development and progression of acquired middle ear cholesteatoma and its prevention and treatment

Research Project

Project/Area Number 16591728
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionJikei University School of Medicine

Principal Investigator

MORIYAMA Hiroshi  Jikei University, School of medicine, Professor, 医学部, 教授 (60125036)

Co-Investigator(Kenkyū-buntansha) KOJIMA Hiromi  Jikei University, School of medicine, Associate Professor, 医学部, 助教授 (60234762)
TANAKA Yasuhiro  Jikei University, School of medicine, Lecturer, 医学部, 講師 (40266648)
YOSHIKAWA Mamoru  Jikei University, School of medicine, Lecturer, 医学部, 講師 (50277092)
WADA Kota  Jikei University, School of medicine, Research Assistant, 医学部, 助手 (20307482)
YAGUCHI Yuichiro  Jikei University, School of medicine, Research Assistant, 医学部, 助手 (30307475)
Project Period (FY) 2004 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2005: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2004: ¥1,400,000 (Direct Cost: ¥1,400,000)
Keywordsepithelium growth / differentiation and apoptosis / cytokine / epidermal growth factor / mucosal gas exchange / mucosal regeneration / pathogenesis of cholesteatoma / 中耳真珠腫 / 粘性再生 / 弛緩部陥凹 / immigration / 人工三次元的皮膚モデル / 難治性滲出性中耳炎 / サイトカインネットワーク
Research Abstract

We conducted a basic and clinical study in relation to the mechanism of development and progression of acquired cholesteatoma and simultaneously assessed the pathology of acquired cholesteatoma, surgical procedures, postoperative results, postoperative course, recurrence, factors related to hearing improvement, and selection criteria for appropriate surgery.
The mechanisms of development and progression are postulated to be based on three. stages. In the first stage, there is retraction in the pars flaccid, and it is due to accumulation of fluid associated with intractable otitis media, the development of negative pressure as a result of impaired mucosal gas metabolism caused by mucosal lesions, and repair of inflammation. Interaction between of narrowing of bone morphology around the epitympanic recess associated with suppression of air cell formation and the formation of mucosal folds also appears to be involved. However, cholesteatomas do not develop as a result of these morphologica … More l changes alone, and persistence of chronic inflammation in the epitympanic recess space is necessary as the second stage. In other words, as a result of thickening of the stroma due to the spread of the inflammation the lower surface of the depressed epithelium leads to the formation of complex narrow pockets. Following epidermal proliferation and granulation as a result of acute exacerbation of the inflammation, the depressed cyst wall partially collapses. As stratified squamous epithelium replaces the mucosal epithelium, it immigrates into the mucosal spaces and exhibits a complex morphology. In the third stage there is involvement by cytokines as a result of accumulation of debris and infection. Cholesteatomas presumably progress by a vicious cycle of inflammation in which epidermal proliferation is induced by cross talk between the subepidermal tissue, including the stimulation by subepithelial fibroblasts, etc., due to impairment of the barrier function of the cholesteatoma epithelium. Less

Report

(4 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (20 results)

All 2006 2005 2004

All Journal Article (19 results) Book (1 results)

  • [Journal Article] 癒着性中耳炎の治療 -粘膜再生を期待して-2006

    • Author(s)
      小島博己
    • Journal Title

      Otology Japan 16(1)

      Pages: 5-12

    • NAID

      10021295678

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Congenital cholesteatoma clinical features and Surgical results.2006

    • Author(s)
      Kojima H, Tanaka Y, Shiwa M, Sakurai Y, Moriyama H
    • Journal Title

      Am J Otolaryngol Head Neck Med Surg 27

      Pages: 299-305

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Identification of specific Gene expression profiles in fibroblasts derived from middle ear cholesteatoma2006

    • Author(s)
      Yoshikawa M, et al.
    • Journal Title

      Arch Otolaryngol Head Neck Surg 132(6)

      Pages: 734-742

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] In vitro reconstruction of a three-dimensional middle ear mucosal organ and its in vivo transplantation2006

    • Author(s)
      Wada K, Tanaka Y, et al.
    • Journal Title

      Acta Oto-Laryngolgica 126

      Pages: 801-810

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Treatment of adhesion middle ear chole- steatoma (in Japanese).2006

    • Author(s)
      Kojima H.
    • Journal Title

      Otol Jpn 16

      Pages: 5-12

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Congenital cholesteatoma clinical features and Surgical results.2006

    • Author(s)
      Kojima H, et al.
    • Journal Title

      Am J Otolaryngol 27

      Pages: 299-305

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Identification of specific Gene expression profiles in fibroblasts derived from middle ear cholesteatoma.2006

    • Author(s)
      Yoshikawa M, et al.
    • Journal Title

      Arch Otolaryngol Head Neck Surg 132(6)

      Pages: 734-42

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] In vitro reconstruction of a three-dimensional middle ear mucosal organ and its in vivo transplantation.2006

    • Author(s)
      Wada K, Tanaka Y, et al.
    • Journal Title

      Acta Oto-Laryngolgica 126

      Pages: 801-10

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Congenital cholesteatoma clinical features and surgical results2006

    • Author(s)
      Kojima H, Tanaka Y, Shiwa M, Sakurai Y, Moriyama
    • Journal Title

      Am J Otolaryngol Head Neck Med Surg 27

      Pages: 299-305

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Identification of specific Gene expression profiles in fibro blasts derived from middle ear cholesteatoma2006

    • Author(s)
      Yoshikawa M, et al.
    • Journal Title

      Arch Otolaryngol Head Neck Surg 2006; 132(6) : 734-42 132(6)

      Pages: 734-42

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 癒着性中耳炎の治療-粘膜再生を期待して-2006

    • Author(s)
      小島博巳
    • Journal Title

      Otology Japan 16(1)

      Pages: 5-12

    • NAID

      10021295678

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 弛緩部型真珠腫に対する適切な術式選択の基準について2005

    • Author(s)
      森山 寛, 小島博己, 志和成紀, 田中康広, 他
    • Journal Title

      耳鼻咽喉科展望 48(1)

      Pages: 18-27

    • NAID

      130003975349

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Creation of a cholesteatoma model using three-dementional cultured skin equivalents2005

    • Author(s)
      Tanaka Y, et al.
    • Journal Title

      Laryngoscope 115

      Pages: 1421-1427

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Appropriate standard for surgery of pars Flaccida cholesteatoma (in Japanese).2005

    • Author(s)
      Moriyama H, et al.
    • Journal Title

      Jibitenbo 48

      Pages: 18-27

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Creation of a cholesteatoma model using three-dimentional cultured skin equivalents.2005

    • Author(s)
      Tanaka Y, et al.
    • Journal Title

      Laryngoscope 115

      Pages: 1421-7

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 三次元培養皮膚を用いた実験的真珠腫モデルの作製2005

    • Author(s)
      田中康弘, 小島博巳, 谷口 雄一郎, 和田弘太, 森山 寛
    • Journal Title

      Otology Japan 15,4 407 2004 15(4)

      Pages: 551-551

    • NAID

      10020400518

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 弛緩部型真珠腫に対する適切な術式選択の基準について2005

    • Author(s)
      森山 寛, 小島博己, 志和成紀, 田中康広, 宮崎日出海
    • Journal Title

      耳鼻咽喉科展望 48(1)

      Pages: 18-27

    • NAID

      130003975349

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Pathology and treatment of middle ear Holesteatoma 2004 (in Japanese).2004

    • Author(s)
      Moriyama H, et al.
    • Journal Title

      Monogram of the Japan ORLSociety Meeting

      Pages: 1-315

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article]2004

    • Author(s)
      森山 寛
    • Journal Title

      中耳真珠腫の病態と治療2004(日耳鼻宿題報告モノグラフ)

      Pages: 1-315

    • Related Report
      2004 Annual Research Report
  • [Book] 中耳真珠腫の病態と治療20042004

    • Author(s)
      森山 寛, 他
    • Publisher
      東京慈恵会医科大学耳鼻咽喉科学教室発行
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary

URL: 

Published: 2004-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi