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Recordings of intrinsic signals in response to odors in the olfactory cortex.

Research Project

Project/Area Number 16591735
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionKANAZAWA MEDICAL UNIVERSITY

Principal Investigator

ONODA Norihiko  Kanazawa Medical Univ., Sch.of Med, Prof., 医学部, 教授 (60106903)

Co-Investigator(Kenkyū-buntansha) TOMODA Kouichi  Kanazawa Medical Univ., Sch.of Med., Prof., 医学部, 教授 (50164041)
SUGAI Tokio  Kanazawa Medical Univ., Sch.of Med., Assoc.Prof., 医学部, 助教授 (90064625)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 2005: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2004: ¥1,700,000 (Direct Cost: ¥1,700,000)
KeywordsGuinea pig / Piriform cortex / Intrinsing signal / Odor concentration / Concentration- gradient / 内因性信号の起源
Research Abstract

By optical imaging of intrinsic signals, we demonstrated a possible code for odor concentration in the anterior piriform cortex of the guinea-pig. Odor-induced cortical activation, which primarily originated in layer II, appeared in a narrow band beneath the rhinal sulcus over the lateral olfactory tract, corresponding to the dorsal part of the anterior piriform cortex. Lower concentrations activated the rostral region of the band, whereas higher ones generated caudally spreading activation, and the site at which neural activation reached its maximum extent depended upon odor concentration. Different odors with low concentrations generated distinct but somewhat overlapping patterns in the rostral region of the band, the limited extent of cortical activity may be one focal domain for each odor. It was hard to judge, however, that odor-specific domains appeared in the anterior piriform cortex, because the strong stimuli induced largely overlapping patterns. Furthermore, the total area activated increased in proportion to concentrations raised to a power of 0.5 to 0.9. Importantly, these imaging results were confirmed with unit recordings which indicated a rostro-caudal gradient in odor- sensitivity among cortical neurons. Our results suggest that the dorsal part of the anterior piriform cortex may be associated with odor concentration. Therefore, in addition to recruitment of more olfactory sensory cells and glomeruli in response to stronger stimuli, a rostro-caudal gradient in axonal projections from mitral/tufted cells and/or in association fibers may play an important role in odor-concentration coding in the anterior piriform cortex.

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (16 results)

All 2006 2005 2004

All Journal Article (16 results)

  • [Journal Article] 嗅覚中枢(嗅球および梨状皮質)における内因性光信号のイメージング2006

    • Author(s)
      小野田法彦 他
    • Journal Title

      金沢医科大学雑誌 30・4(印刷中)

    • NAID

      110006198462

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Imaging of intrinsic signals in the olfactory cortex and bulb.2006

    • Author(s)
      Onoda N et al.
    • Journal Title

      J.Kanazawa Med. 30(4)(in press)

    • NAID

      110006198462

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 嗅覚中枢(嗅球および梨状皮質)における内因性光信号のイメージング2006

    • Author(s)
      小野田法彦 他
    • Journal Title

      金沢医科大学雑誌 48

      Pages: 294-302

    • NAID

      110006198462

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Odor-intensity coding in the anterior piriform cortex.2005

    • Author(s)
      Onoda N et al.
    • Journal Title

      Chemical Senses 30

      Pages: 162-163

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Odor-concentration coding in the guinea-pig piriform cortex.2005

    • Author(s)
      Sugai T et al.
    • Journal Title

      Neuroscience 130

      Pages: 769-781

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Developmental changes in oscillatory and slow responses of the rat accessory olfactory bulb.2005

    • Author(s)
      Sugai T et al.
    • Journal Title

      Neuroscience 134

      Pages: 605-616

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Ettects of n-methyl-d-aspartate glutamate receptor antagonists on oscillatory signal propagation in the guinea-pig accessory olfactory bulb slice : Characterization by optical, field potential and patch clamp recording.2005

    • Author(s)
      Sugai T et al.
    • Journal Title

      Neuroscience 135

      Pages: 583-594

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 内因性光計測によるラット副嗅球の尿刺激に対する応答2005

    • Author(s)
      小野田法彦 他
    • Journal Title

      日本味と匂学会誌 12

      Pages: 459-460

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Effects of n-methyl-d-aspartate glutamate receptor antagonists on oscillatory signal propagation in the guinea-pig accessory olfactory bulb slice : Characterization by optical, field potential and patch clamp recording.2005

    • Author(s)
      Sugai T et al.
    • Journal Title

      Neuroscience 135

      Pages: 583-594

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Urinary responses revealed by optical imaging of intrinsic signals in the rat accessory olfactory bulb.2005

    • Author(s)
      Onoda N et al.
    • Journal Title

      Jpn.J.Taste Smell.Res. 12

      Pages: 459-460

    • NAID

      110004614800

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Odor-concentration coding in the guinea-pig piriform cortex2005

    • Author(s)
      Sugai T et al.
    • Journal Title

      Neuroscience 130

      Pages: 769-781

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Odor-intensity coding in the anterior piriform cortex.2005

    • Author(s)
      Onoda N, Sugai T, Yoshimura H
    • Journal Title

      Chemical Senses 30

      Pages: 162-163

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Odor-concentration coding in the guinea-pig piriform cortex2005

    • Author(s)
      Sugai T, Miyazawa T, Fukuda M, Yoshimura H, Onoda N
    • Journal Title

      Neuroscience 130

      Pages: 769-781

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 嗅覚中枢(嗅球および梨状皮質)における内因性光信号のイメージング2004

    • Author(s)
      小野田法彦 他
    • Journal Title

      神経研究の進歩 48

      Pages: 294-302

    • NAID

      110006198462

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Imaging of intrinsic signals in the olfactory cortex and bulb.2004

    • Author(s)
      Onoda N et al.
    • Journal Title

      Adv.Neurol.Sci. 48

      Pages: 294-302

    • NAID

      110006198462

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 嗅覚中枢(嗅球および梨状皮質)における内因性光信号のイメージング2004

    • Author(s)
      小野田法彦, 須貝外喜夫
    • Journal Title

      神経研究の進歩 48

      Pages: 294-302

    • NAID

      110006198462

    • Related Report
      2004 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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