| Project/Area Number |
16591767
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | JUNTENDO UNIVERSITY |
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Principal Investigator |
TANAKA Minoru JUNTENDO UNIVERSITY, 医学部, 教授 (00053314)
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| Co-Investigator(Kenkyū-buntansha) |
INOUE Junji JUNTENDO UNIVERSITY, MEDICINE, ASSISTANT, 医学部, 助手 (30365580)
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2005: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2004: ¥2,400,000 (Direct Cost: ¥2,400,000)
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| Keywords | microplasmin / diabetes / diabetic macular edema / vitreous detachment / vitrectomy / laser therapy / ultrasound |
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| Research Abstract |
Diabetic macular edema is a major cause of decreased visual acuity. Among several therapy for the disease, vitrectomy has been employed with favorable effect as a result of inducing posterior vitreous detachment (PVD). In order to avoid complications following vitrectomy, enzymatic vitrectomy, inducing PVD with single injection of plasmin into the vitreous cavity, has been applied to the diabetic macular edema.
Recombinant microplasmin (rmpli) was injected into the vitreous cavity of experimental animal and electrophysiological as well as histological studies were carried out, in addition to in vivo ultrasound examination. The injection of rmpli induced PVD in experimental without ill effect to each eyes. Because clinical experiment is now going on in Europe and U.S., We used autologous plasmin for 53 cases of the disease with good results. The rmpli will be one of the effective intraoperative adjunct to treat diabetic macular edema.
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