| Project/Area Number |
16591805
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Plastic surgery
|
|---|
| Research Institution | Osaka Medical College |
|---|
Principal Investigator |
UEDA Koichi Osaka Medical College, Faculty of Medicine, Professor, 医学部, 教授 (90257858)
|
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| Co-Investigator(Kenkyū-buntansha) |
TSUJI Motomu Osaka Medical College, Faculty of Medicine, Associate Professor, 医学部, 准教授 (60144466)
OBA Sosuke Osaka Medical College, Faculty of Medicine, Associate Professor, 医学部, 准教授 (80233253)
YASUDA Yoshiko Kinki University, Faculty of Medicine, Professor, 医学部, 教授 (10025629)
|
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| Project Period (FY) |
2004 – 2006
|
| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2006: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 2005: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2004: ¥700,000 (Direct Cost: ¥700,000)
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|---|
| Keywords | keloid / hypertrophic scar / immunohistochemistry / VEGF / 虚血 |
|---|
| Research Abstract |
We have previously shown that the adenosine triphosphate (ATP) content of keloids remains high for a long time. In keloids, anaerobic glycolysis may be related to the production of ATP. In this study, we counted the vessels in keloids, hypertrophic and atrophic scars in a defined area, and measured the cross-sectional areas of their internal lumens immunohistopathologically and the lactate concentrations. The mean number in a defined area was smallest in keloids as was the mean internal area of vessels. The decreased and narrowed vessels may reduce oxygen perfusion. The blood supply to keloids is inadequate, and this persists.
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