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Induction of inflammatory immune response by streptococcal water-insoluble α-glucans and association with periodontal diseases

Research Project

Project/Area Number 16591824
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Morphological basic dentistry
Research InstitutionFukuoka Dental College

Principal Investigator

OKAMOTO Shigefumi  Fukuoka Dental College, Faculty of Dentistry, Lecturer, 歯学部, 講師 (50311759)

Co-Investigator(Kenkyū-buntansha) KAWABATA Shigetada  Osaka University, Graduate School of Dentistry, Associate Professor, 大学院・歯学研究科, 助教授 (50273694)
NAKAGAWA Ichiro  Osaka University, Graduate School of Dentistry, Assistant Professor, 大学院・歯学研究科, 講師 (70294113)
HAMADA Shigeyuki  Nihon University, Advanced Research Institute for the Sciences and Humanities, Professor, 大学院・総合科学研究科, 教授 (60028777)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2005: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2004: ¥2,600,000 (Direct Cost: ¥2,600,000)
KeywordsSteptococcus sobrinus / water-insoluble α-glucans / inflammatory immune responses / periodontal diseases / 遊走能 / 活性酸素 / レンサ球菌 / 免疫応答
Research Abstract

Water-insoluble α-glucans (WIG) are synthesized from sucrose by the glucosyltransferase-I of mutans streptococci, that play an important role in the development of dental plaque. We found that WIG synthesized by Streptococcus sobrinus activated mouse peritoneal exudate macrophages to produce cytokines. The immunological responses were not due to contamination by sucrose, water-soluble glucan, lipopolysaccharide, or peptidoglycan. WIG stimulated human monocytes to produce TNF-α and IL-8. Human polymorphonuclear cells were also activated by WIG, resulting in chemotaxis of the cells and production of hydrogen peroxide. These results suggest that WIG modulate macrophage- and granulocyte-induced inflammatory immune responses. Furthermore, since WIG injured human oral squamous cells directly, we speculate that oral squamous cell injury and inflammation induced by α-glucans are associated with the development of periodontal diseases.

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (13 results)

All 2005 2004

All Journal Article (12 results) Book (1 results)

  • [Journal Article] Systemic immunization with streptococcal immunoglobulin-binding protein Sib35 induces protective immunity against group A Streptococcus challenge in mice.2005

    • Author(s)
      Okamoto, S., Tamura, Y., Terao, Y., Hamada, S., Kawabata,S.
    • Journal Title

      Vaccine 23.40

      Pages: 4852-4859

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Protective immunity against Streptococcus pyogenes challenge in mice following immunization with fibronectin-binding protein.2005

    • Author(s)
      Terao, Y., Okamoto, S., Kataoka, K., Hamada, S., Kawabata,S
    • Journal Title

      The Journal of Imfectios Diseases 192.12

      Pages: 2081-2091

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Systemic immunization with streptococcal immunoglobulin-binding protein Sib35 induces protective immunity against group A Streptococcus challenge in mice.2005

    • Author(s)
      Okamoto, S., Tamura, Y., Terao, Y., Hamada, S., Kawabata, S.
    • Journal Title

      Vaccine 23

      Pages: 4852-4859

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Protective immunity against Streptococcus pyogenes challenge in mice following immunization with fibronectin-binding protein.2005

    • Author(s)
      Terao, Y., Okamoto, S., Kataoka, K., Hamada, S., Kawabata, S.
    • Journal Title

      Journal of Infectious Diseases 192

      Pages: 2081-2091

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Systemic immunization with streptococcal immunoglobulin-binding protein Sib35 induces protective immunity against group A Streptococcus challenge in mice.2005

    • Author(s)
      Okamoto, S., et al.
    • Journal Title

      Vaccine 23・40

      Pages: 4852-4859

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Protective immunity against Streptococcus pyogenes challenge in mice following immunization with fibronectin-binding protein.2005

    • Author(s)
      Terao, Y., Okamoto, et al.
    • Journal Title

      The Journal of Infectious Diseases 192・12

      Pages: 2081-2091

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Systemic immunization with streptococcal immunoglobulin-binding protein Sib35 induces protective immune responses against group A Streptococcus challenge in mice2005

    • Author(s)
      Okamoto, S., et al.
    • Journal Title

      Vaccine (印刷中)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] The Streptococcus pyogenes capsule is required for adhesion of bacteria to virus-infected alveolar epithelial cells and lethal bacterial-viral superinfection.2004

    • Author(s)
      Okamoto, S., Kawabata, S., Terao, Y., Fujitaka, H., Okuno, Y., Hamada,S.
    • Journal Title

      Infection and Immunity 72.10

      Pages: 6068-6075

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The Streptococcus pyogenes capsule is required for adhesion of bacteria to virus-infected alveolar epithelial cells and lethal bacterial-viral superinfection.2004

    • Author(s)
      Okamoto, S., Kawabata, S., Terao, Y., Fujitaka, H., Okuno, Y., Hamada, S.
    • Journal Title

      Infection and Immunity 72

      Pages: 6068-6075

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A model of invasive type of Streptococcus pyogenes infection after intranasal infection in influenza A virus.2004

    • Author(s)
      Okamoto, S., Kawabata, S., Nakagawa, I., Okuno, Y., Goto, T., Sano, K., Hamada, S.
    • Journal Title

      International Congress Series 163

      Pages: 733-736

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Vaccination with formalin-inactivated influenza vaccine protects mice against influenza-Streptococcus pyogenes superinfection2004

    • Author(s)
      Okamoto, S., et al.
    • Journal Title

      Vaccine 29・22

      Pages: 2887-2893

    • Related Report
      2004 Annual Research Report
  • [Journal Article] The streptococcus pyogenes capsule is required for Adhesion of bacteria to virus infected alveolar epithelial cells and lethal bacterial-viral superinfection2004

    • Author(s)
      Okamoto, S., et al.
    • Journal Title

      Infection and Immunity 72・10

      Pages: 6068-6075

    • Related Report
      2004 Annual Research Report
  • [Book] International Congress Series Vol : 12632004

    • Author(s)
      Kawaoka Y
    • Total Pages
      4
    • Publisher
      Elsevier
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary

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Published: 2004-04-01   Modified: 2016-04-21  

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