| Project/Area Number |
16591825
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
YOSHIDA Atsushi Osaka University, Graduate School of Dentistry, Professor, 大学院・歯学研究科, 教授 (90201855)
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| Co-Investigator(Kenkyū-buntansha) |
MORITANI Masayuki Osaka University, Graduate School of Dentistry, Assistant Professor, 大学院・歯学研究科, 講師 (80303981)
ONO Takahiro Osaka University, Graduate School of Dentistry, Associate Professor, 大学院・歯学研究科, 助教授 (30204241)
TAKEMURA Motohide Osaka University, Graduate School of Dentistry, Associate Professor, 大学院・歯学研究科, 助教授 (70192169)
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2005: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2004: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | swallow / mastication / trigeminal / facial / cortex / premotor / premotoneuron / interneuron |
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| Research Abstract |
Mastication and swallowing are consisted of a series of contractions of several kinds of muscles. However it is still unclear how premotoneurons (preMo) controlling their target motoneurons are regulated for these movements. Therefore, in the first year, 2004,of this grant, we tried to reveal locations of the preMo and connection between these preMo and the cortical neurons. Adult rats were used. We revealed that preMo projecting to the trigeminal motor nucleus are located in the trigeminal oral (Vo) nucleus, the pontine lateral reticular formation where posterior digastic motoneurons and stylohyoid motoneurons exist, and that there are cortical neurons giving off their axon terminals in the trigeminal oral nucleus and the two parts of the reticular formation.
In the second year,2005,of this grant, we tried to promote the study done in 2004,and revealed that there exist two kinds of Vo neurons which project ipsilaterally to either the jaw-closing or -opening motor nucleus, and that, in the Vo neurons with the ipsilateral projection, some neurons also project to the contralateral jaw-closing or -opening motor nucleus. Further, we revealed that the Vo neurons receive direct descending projections from neurons in the rostral part of the primary and secondary somatosensory cortex and that the descending projections are bilateral with a contralateral predominance.
As described above, this study succeeded in producing a useful information of the central neuronal mechanisms of the swallowing and in contributing greatly to the progress of oral biology.
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