| Project/Area Number |
16591851
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Fukuoka Dental College |
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Principal Investigator |
KAMINISHI Hidenori Fukuoka Dental College, Infection Biology, Professor, 歯学部, 教授 (90084300)
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| Co-Investigator(Kenkyū-buntansha) |
CHO Tamaki Fukuoka Dental College, Infection Biology, Associate Professor, 歯学部, 准教授 (90131870)
OGURA Rieko Fukuoka Dental College, Infection Biology, Lecture, 講師 (80320331)
竹内 尚子 福岡歯科大学, 歯学部, 助手 (50198800)
渡辺 泰雄 東京医科大学, 医学部, 助教授 (70183720)
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| Project Period (FY) |
2004 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 2006: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2005: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2004: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | Candida albicans / differentiation induction / neurotrophy / nerve protection / NAD / chemical synthesis / Sepabeads SP207 / SephadexLH-20 / 低分子物質 |
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| Research Abstract |
This research was carried out to clarify the composition analysis the chemical structure of nerve protection and nutritional factor which located in the intracellular of Candida albicans
Chemical composition and structure analysis were carried out by the execution of mass spectrometry analysis and NMR analysis using the isotope variously in respect of the material which separated from the fungus. As this result, the result that that the material got from Candida albicans is hydrophilic and that the molecular weight is 663, and that it is analog (β-L-NAD) of the new NAD from result of analysis was indicated was obtained.
By four passing steps of the result of examining the method of chemical synthesis based on result of analysis, the specified substance should be got, and the synthesis was started. At present, the second step is the progressing, and the chemical synthesis sample will be got in the near future.
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