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Role of the neural network of the brain stem in the inhibition of the rhythmical jaw movements

Research Project

Project/Area Number 16591856
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Functional basic dentistry
Research InstitutionMatsumoto Dental University

Principal Investigator

MASUDA Yuji  Matsumoto Dental University, Graduate School for Oral Medicine, Professor, 大学院・歯学独立研究科, 教授 (20190366)

Co-Investigator(Kenkyū-buntansha) KOBAYASHI Masayuki  Osaka University, Graduate School for Dentistry, Assistant Professor, 大学院・歯学研究科, 講師 (00300830)
MORITANI Masayuki  Osaka University, Graduate School for Dentistry, Assistant Professor, 大学院・歯学研究科, 講師 (80303981)
MORIMOTO Toshifumi  Osaka University, Graduate School for Oral Medicine, Professor, 大学院・歯学独立研究科, 教授 (20028731)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2005: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 2004: ¥2,000,000 (Direct Cost: ¥2,000,000)
Keywordsmastication / jaw movement / brain stem / cortical masticatory area
Research Abstract

It has been known that electrical stimulation to the focal area in the brain stem inhibits the rhythmical jaw movements (RJMs) evoked by repetitive stimulation to the cortical masticatry area (CMA). However, the physiological significance of that area has not been clarified. First, the neural network involved in the inhibitory effect on the RJMs was investigated in the rabbit using neuro-tracing methods. The inhibitory area was identified in the reticular formation adjacent to the periaqueductal gray matter. Injection of the anterograde tracer biocytine or retrograde tracer fluoro-gold was in this area conformed by the inhibitory effect. Labeled terminals by biocytine were found in the medial pontine reticular nucleus, and labeled cell by fluoro-gold was also found in the medial pontine reticular nucleus. This suggests that the reciprocal connection between the reticular formation adjacent to the periaqueductal gray matter and the medial pontine reticular nucleus may involved in the inhibitory effect on RJMs. Second, in order to know the feature of cortically induced RJMs, we investigated the cortico-striatal pathway from the CMA of the rabbit with electrophysiology and anatomical technique. Evoked potentials by stimulation to the CMA were recorded from the ventral part of the putamen. Injection of biocytine to the CMA resulted in that labeled terminals were located in the ventral part of the putamen. It is suggested that the ventral part of the putamen may involved in the control of masticatory movements.

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (29 results)

All 2006 2005 2004

All Journal Article (25 results) Book (4 results)

  • [Journal Article] Serotonin suppresses evoked EPSPs in superficial layers neurons of rat trigeminal caudal nucleus.2006

    • Author(s)
      Kobayashi, M. et al.
    • Journal Title

      Dentistry in Japan 42

      Pages: 31-34

    • NAID

      10019595302

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Serotonin suppresses evoked EPSPs in superficial layers neurons of rat trigeminal caudal nucleus.2006

    • Author(s)
      Kobayashi, M.et al.
    • Journal Title

      Dentistry in Japan 42

      Pages: 31-34

    • NAID

      10019595302

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Serotonin suppresses evoked EPSPs in superficial layers neurons of rat trigeminal caudal nucleus.2006

    • Author(s)
      Kobayashi, M. et al.
    • Journal Title

      Dentistry in Japan (in press)

    • NAID

      10019595302

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Different corticostriatal projections from two parts of the cortical masticatory area in the rabbit.2005

    • Author(s)
      Masuda, Y. et al.
    • Journal Title

      Exp. Brain. Res. 146

      Pages: 501-510

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Micro-computed tomography newly developed for in vivo small imaging.2005

    • Author(s)
      Arai, Y. et al.
    • Journal Title

      Oral Radiol. 21

      Pages: 14-18

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Involvement of dorsal column nucleus neurons in nociceptive transmission in aged rats.2005

    • Author(s)
      Kitagawa, J. et al.
    • Journal Title

      J. Neurophysiol. 94・6

      Pages: 4178-4187

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Comparisons between excitatory and inhibitory mechanisms on jaw-closing motoneurons.2005

    • Author(s)
      Moritani, M. et al.
    • Journal Title

      Dentistry in Japan 41

      Pages: 8-12

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Elimination of neurokinin-1 receptor neurons in caudal nucleus reverses the effects of systemic bicuculline on c-Fos expression in rat trigeminal sensorynucleus : 12005

    • Author(s)
      Abe, T.et al.
    • Journal Title

      Neuroscience 133・3

      Pages: 739-747

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The distribution of inhibitory and excitatory synapses on single, reconstructed jaw-opening motoneurons in the cat.2005

    • Author(s)
      Shigenaga, Y. et al.
    • Journal Title

      Neuroscience 133・2

      Pages: 507-518

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Bilateral projection of functionally characterized trigeminal oralis neurons to trigeminal motoneurons in cats.2005

    • Author(s)
      Yoshida, A. et al.
    • Journal Title

      Brain Res. 1036・1-2

      Pages: 208-212

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] 大脳皮質および大脳基底核の咀嚼運動制御における機能的意義2005

    • Author(s)
      増田裕次
    • Journal Title

      松本歯学 31

      Pages: 1-9

    • NAID

      80017785713

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Different corticostriatal projections from two parts of the cortical masticatory area in the rabbit.2005

    • Author(s)
      Masuda, Y.et al.
    • Journal Title

      Exp.Brain Res. 146

      Pages: 501-510

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Micro-computed tomography newly developed for in vivo small imaging.2005

    • Author(s)
      Arai, Y.et al.
    • Journal Title

      Oral Radiol. 21

      Pages: 14-18

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Involvement of dorsal column nucleus neurons in nociceptivetransmission in aged rats.2005

    • Author(s)
      Kitagawa, J.et al.
    • Journal Title

      J.Neurophysiol 94(6)

      Pages: 4178-4187

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Comparisons between excitatory and inhibitory mechanisms on jaw-closing motoneurons.2005

    • Author(s)
      Moritani, M.et al.
    • Journal Title

      Dentistry in Japan 41

      Pages: 8-12

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Elimination of neurokinin-1 receptor neurons in caudal nucleus reverses the effects of systemic bicuculline on c-Fos expression in rat trigeminal sensorynucleus : I2005

    • Author(s)
      Abe, T.et al.
    • Journal Title

      Neuroscience 133(3)

      Pages: 739-747

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The distribution of inhibitory and excitatory synapses on single, reconstructed jaw-opening motoneurons in the cat.2005

    • Author(s)
      Shigenaga, Y.et al.
    • Journal Title

      Neuroscience 133(2)

      Pages: 507-518

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Bilateral projection of functionally characterized trigeminal oralis neurons to trigeminal motoneurons in cats.2005

    • Author(s)
      Yoshida, A.et al.
    • Journal Title

      Brain Res. 1036(1-2)

      Pages: 208-212

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Different corticostriatal projections from two parts of the cortical masticatory area in the rabbit.2005

    • Author(s)
      Masuda, Y. et al.
    • Journal Title

      Exp.Brain Res. 161・3

      Pages: 397-404

    • Related Report
      2005 Annual Research Report 2004 Annual Research Report
  • [Journal Article] Micro-computed tomography newly developed for in vivo small imaging.2005

    • Author(s)
      Arai, Y. et al.
    • Journal Title

      Oral radiology. 21・1

      Pages: 14-18

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Involvement of dorsal column nucleus neurons in nociceptive transmission in aged rats.2005

    • Author(s)
      Kitagawa, J. et al.
    • Journal Title

      J.Neurophysiol. 94・6

      Pages: 4178-4187

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Elimination of neurokinin-1 receptor neurons in caudal nucleus reverses the effects of systemic bicuculline on combs expression in rat trigeminal sensorynucleus : I2005

    • Author(s)
      Abe, T.et al.
    • Journal Title

      Neuroscience 133・3

      Pages: 739-747

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 大脳皮質および大脳基底核の咀嚼運動制御における機能的意義.2005

    • Author(s)
      増田裕次
    • Journal Title

      松本歯学 31

      Pages: 1-9

    • NAID

      80017785713

    • Related Report
      2005 Annual Research Report
  • [Journal Article] どうして寝ているときにいびきや歯ぎしりをするのだろうか?2005

    • Author(s)
      加藤隆史他
    • Journal Title

      デンタルダイヤモンド 30・15

      Pages: 76-77

    • Related Report
      2005 Annual Research Report
  • [Journal Article] どうして髪の毛1本でも口の中にあると感じるのだろうか?2005

    • Author(s)
      増田裕次 他
    • Journal Title

      デンタルダイヤモンド 30・1

      Pages: 142-145

    • Related Report
      2004 Annual Research Report
  • [Book] 口腔運動機能制御 In 歯科薬理学 (第5版)2005

    • Author(s)
      増田裕次
    • Total Pages
      3
    • Publisher
      医歯薬出版
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 口腔運動機能制御 In 歯科薬理学(第5版)2005

    • Author(s)
      増田裕次
    • Total Pages
      3
    • Publisher
      医歯薬出版
    • Related Report
      2005 Annual Research Report
  • [Book] Trigeminal neuronal recording in animal models of persistent orofacial pain. In Pain Research : Methods and Protocols.2004

    • Author(s)
      Iwata et al.
    • Total Pages
      15
    • Publisher
      Human Press
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] Trigeminal neuronal recording in animal models of persistent orofacial pain. In Pain Research : Methods and Protocols.2004

    • Author(s)
      Iwata, K. et al.
    • Total Pages
      14
    • Publisher
      Human Press
    • Related Report
      2004 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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