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Changes in long-term adhesive property and biocompatibility of 4- META/MMA-TBB resin in vitro and vivo.

Research Project

Project/Area Number 16591903
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Conservative dentistry
Research InstitutionHokkaido University

Principal Investigator

TANAKA Saori  Hokkaido Univ., Hokkaido Univ. Hospital., Inst., 大学病院, 助手 (90344522)

Co-Investigator(Kenkyū-buntansha) SUGAYA Tsutomu  Hokkaido Univ., Grad. School of Dental Medicine, Asso. Prof., 大学院歯学研究科, 助教授 (10211301)
Project Period (FY) 2004 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2006: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2005: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2004: ¥900,000 (Direct Cost: ¥900,000)
Keywords4META / MMA-TBB resin / root-end sealant / bonding treatment / sealing ability / biocompatibility
Research Abstract

4-META/MMA-TBB resin has been used for the bonding of vertically fractured roots and apicoectomy. It has good characteristics, such as adhesive properties to dentin and cementum.
However, some studies demonstrated that the collagen fibrils that are not enveloped by resin may become susceptible to water degradation in the long-term.
The purpose: to evaluate the longitudinal changes in biocompatibility and mechanical properties of 4- META/MMA-TBB resin in vitro and vivo.
1.Mechanical properties and Biocompatibility: After mixing the resin, these specimens each were stored in horse serum or in air for lday, lmonth, 3month,6month and lyear at 37_. After each periods, they were examined.
1)micro-tensile bond strength (MTBS): for cementum, there is not difference between the values at 1- year and at 1-day
2)hardness: at lyear was higher than at 1 day. The value in air was higher than in serum.
3)biocompatibility: increased within 1 year and this increase was more delayed in serum than in air.
2.Cha … More nges of Biocompatibility in vivo
Mandibular incisors and premolars of 2 dogs were used. The root canals were contaminated with dental plaque and apical periodontitis was induced. They were divided into 4 groups. Following the roots were resected, root-end surface was prepared slightly concave, Super bond(SB) was applied. In EBA and MTA group, root-end cavities were prepared and retrofilled. In no filling group, no retrograde filling was performed.
Healing was evaluated radiographically and examined histologically 3months after the surgery. SB and MTA group : a normal periodontal ligament space, and some roots showed reduced area of periradicular radiolucency compared with that before surgery. Little inflammation was observed. In no filling and EBA group, some roots showed enlarged area of periradicular radiolucency compared with that before surgery, and more inflammation was observed.
Conclusion: root-end sealing and bonding treatment using 4-META/MMA-TBB resin induce good prognoses by good biocompatibility and mechanical properties. Less

Report

(4 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (11 results)

All 2007 2006 2005

All Journal Article (11 results)

  • [Journal Article] Hybrid Layer Seals the Cementum / 4-META/MMA-TBB Resin Interface2007

    • Author(s)
      Saori Tanaka
    • Journal Title

      Journal of Biomedical Material Research Part B Applied Biomaterial 80・1

      Pages: 140-145

    • NAID

      120000971285

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] 垂直歯根破折の接着治療2007

    • Author(s)
      菅谷 勉
    • Journal Title

      日本歯科医学会誌 26

      Pages: 47-51

    • NAID

      10018827098

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Hybrid Layer Seals the Cementu m / 4-META/MMA-TBB Resin Interface2007

    • Author(s)
      Saori Tanaka
    • Journal Title

      Journal of Biomedical Material Research Part B Applied Biomaterial 80(1)

      Pages: 140-145

    • NAID

      120000971285

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Bonding Treatment of Vertica 1 Root Fracture2007

    • Author(s)
      Tsutomu Sugaya
    • Journal Title

      Journal of the Japanese Association for Dental Science 26

      Pages: 47-51

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Changes in biocompatibility of 4-META/MMA-TBB resin in vitvo2006

    • Author(s)
      Saori Tanaka
    • Journal Title

      Journal of Dental Research Special Issues B 85(CD-ROM)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 根尖切除時に4-META/MMA-TBBレジンでroot-end sealingした場合の根尖性歯周炎の治癒2006

    • Author(s)
      長谷川有紀子
    • Journal Title

      日本歯科保存学雑誌 49・2

      Pages: 282-287

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Healing of apical periodonti tis after root-end sealing using 4-META/MMA -TBBresin apicoectomy2006

    • Author(s)
      Yukiko Hasegawa
    • Journal Title

      Jpn J Consery Dent 49(2)

      Pages: 282-287

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Changes in biocompatibility of 4 -META/MMA-TBB resin in vitvo.2006

    • Author(s)
      Saori Tanaka
    • Journal Title

      J Dent Res. 85,84th General Session of the IADR, CD-ROM of abstracts, Spec Iss B

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Changes in biocompatibility of 4-META/MMA-TBB resin in vitvo.2006

    • Author(s)
      Saori Tanaka
    • Journal Title

      Journal of Dental Research Special Issues B 85(CD-ROM)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Root-end sealing using 4-META/MMA-TBB Resin following Apicoectomy2005

    • Author(s)
      Saori Tanaka
    • Journal Title

      2nd. International Congress on Adhesive Dentistry, Program & Abstracts

      Pages: 341-341

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Root-end sealing using 4-META/ MMA-TBB Resin following Apicoectomy.2005

    • Author(s)
      Saori Tanaka
    • Journal Title

      2nd. International Congress on Adhesive Dentistry, Program & Abstracts 341

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary

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Published: 2004-04-01   Modified: 2016-04-21  

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