| Project/Area Number |
16591911
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
TORII Yasuhiro Okayama University Hospital, Professor, 医学部・歯学部附属病院, 教授 (10188831)
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| Co-Investigator(Kenkyū-buntansha) |
ITOTA Toshiyuki Dental School, Research Assistant, 歯学部, 博士研究員 (60294419)
SUZUKI Kazuomi Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Professor, 大学院医歯薬学総合研究科, 教授 (30050058)
YOSHIYAMA Masahiro Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Professor, 大学院医歯薬学総合研究科, 教授 (10201071)
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| Project Period (FY) |
2004 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2006: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2005: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2004: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | Dentin / Adhesion / Composite resin / Amino acid derivative / self-etching primer adhesive / コンポジットレンジ / セルフエッチング・プライマーアドヒーシブ |
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| Research Abstract |
In this study, we investigate the availability as self-etching primer adhesive of the solution containing amino acid derivative monomer, N-acryloyl aspartic acid (N-AAsp).
N-AAsp was synthesized by the reaction between acrylic chloride and DL-aspartic acid. Firstly, it was confirmed that the N-AAsp solution showed effectiveness in the bonding to dentine as a self etching primer.
The addition of polymeric monomer in self-etching primer adhesive is essential due to the polymerization with resin matrix. Therefore, it is necessary that the solution to dissolve N-AAsp contains organic solvent. Our results indicated that the most suitable organic solvent was acetone and the equal weight mixture of acetone and water was the best. Next, the acetone/water solution containing lOwt% N-AAsp, TEGDMA as a polymeric monomer, camphor quinone (CQ) and N, N-dimethyl p-toluidine was prepared, and the bond strength to bovine dentin was measured when dentin was treated with the solutions containing various concentrations of TGDMA. As a result, maximum bond strength was obtained when the dentin was treated with the solution containing lOwt%N-AAsp, 5wt%TEGDMA, 41.5wt% H_2O, 41.5wt% acetone, lwt% CQ and lwt% N.N-dimethyl p-toluidine.
In this study, we could find suitable chemical composition for the self-etching primer adhesive containing N-AAsp. However, our self-etching primer adhesive required using together with the bonding resin due to bad wetting ability with the resin. Therefore, further investigation is necessary for development of an excellent self-etching primer adhesive.
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